Preparations for phase I clinical trials of boron neutron capture therapy at the mit reactor and the New England Medical Center

A team of scientists, engineers and medical researchers from the New England Medical Center (NEMC) and the Massachusetts Institute of Technology's (MIT) Nuclear Reactor Laboratory have been developing Boron Neutron Capture Therapy (BNCT), a binary radiation therapy, for the treatment of refractory tumors such as glioblastoma multiforme and melanoma. After 6 years of effort on several fronts, the interdisciplinary and inter-institutional research group is planning Phase I clinical trials in the near future. This paper briefly reviews the preparations at NEMC/MIT, including the various technologies and research tasks which are important or necessary for the initiation of clinical trials. © Wiley-Liss, Inc.

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