Up-Regulation of AT1 and AT2 Receptors in Postinfarcted Hypertrophied Myocytes and Stretch-Mediated Apoptotic Cell Death

[1]  Q. Li,et al.  Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. , 1998, The Journal of clinical investigation.

[2]  G. W. Snedecor.  STATISTICAL METHODS , 1967 .

[3]  M. Horiuchi,et al.  Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. , 1996, Circulation research.

[4]  Y. Mori,et al.  Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. , 1998, Circulation research.

[5]  M. Pfeffer,et al.  Ventricular Remodeling After Myocardial Infarction: Experimental Observations and Clinical Implications , 1990, Circulation.

[6]  P. Anversa,et al.  Ultrastructural basis of acute left ventricular failure from severe acute aortic stenosis in the rabbit. , 1972, Journal of molecular and cellular cardiology.

[7]  R. Virmani,et al.  Apoptosis in myocytes in end-stage heart failure. , 1996, The New England journal of medicine.

[8]  P. Anversa,et al.  Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. , 1997, Journal of molecular and cellular cardiology.

[9]  P. Anversa,et al.  Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. , 1993, Circulation research.

[10]  P. Anversa,et al.  Angiotensin II Induces Apoptosis of Adult Ventricular MyocytesIn Vitro , 1997 .

[11]  T Delhaas,et al.  An equibiaxial strain system for cultured cells. , 1996, The American journal of physiology.

[12]  M. Capogrossi,et al.  p53 Induces myocyte apoptosis via the activation of the renin-angiotensin system. , 1997, Experimental cell research.

[13]  G Olivetti,et al.  Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats. , 1990, Circulation research.

[14]  E. Sonnenblick,et al.  Cardiac anatomy and ventricular loading after myocardial infarction , 1993 .

[15]  P. Anversa,et al.  Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. , 1999, Circulation research.

[16]  John Calvin Reed,et al.  Identification of a p53-dependent negative response element in the bcl-2 gene. , 1994, Cancer research.

[17]  John Calvin Reed,et al.  Programmed myocyte cell death affects the viable myocardium after infarction in rats. , 1996, Experimental cell research.

[18]  P. Anversa,et al.  ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure. , 1993, The American journal of physiology.

[19]  C. di Loreto,et al.  Myocyte death in the failing human heart is gender dependent. , 1999, Circulation research.

[20]  F. Crea,et al.  Cell death in acromegalic cardiomyopathy. , 1999, Circulation.

[21]  H. Ikeda,et al.  DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. , 1995, The American journal of pathology.

[22]  M. Horiuchi,et al.  Angiotensin II type 2 receptor mediates programmed cell death. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  E. Sonnenblick,et al.  Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes. , 1995, The American journal of physiology.

[24]  R. Passier,et al.  Activation of angiotensin-converting enzyme expression in infarct zone following myocardial infarction. , 1995, The American journal of physiology.

[25]  P. Anversa,et al.  Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. , 1996, Journal of molecular and cellular cardiology.

[26]  D. Lane,et al.  Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. , 1994, Cold Spring Harbor symposia on quantitative biology.

[27]  P. Anversa,et al.  Angiotensin II stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes. , 1998, Circulation research.

[28]  S. Uhlig,et al.  Functional and fine structural changes in isolated rat lungs challenged with endotoxin ex vivo and in vitro. , 1995, The American journal of pathology.

[29]  E. J. Brown,et al.  Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. , 1992, The New England journal of medicine.

[30]  H. Schunkert,et al.  Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. , 1994, The American journal of physiology.

[31]  P. Claudio,et al.  Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. , 1999, The American journal of pathology.

[32]  J. Sadoshima,et al.  Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro , 1993, Cell.

[33]  M. Horiuchi,et al.  Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. , 1998, Life sciences.

[34]  M. Weisfeldt,et al.  Cellular mechanisms of myocardial infarct expansion. , 1988, Circulation.

[35]  P. Anversa,et al.  Down-regulation of the IGF-1 system parallels the attenuation in the proliferative capacity of rat ventricular myocytes during postnatal development. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[36]  M. Horiuchi,et al.  Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis* , 1997, The Journal of Biological Chemistry.

[37]  J W Covell,et al.  Diastolic Geometry and Sarcomere Lengths in the Chronically Dilated Canine Left Ventricle , 1971, Circulation research.

[38]  C A Beltrami,et al.  Apoptosis in the failing human heart. , 1997, The New England journal of medicine.

[39]  P. Anversa,et al.  Angiotensin II activates programmed myocyte cell death in vitro. , 1997, Experimental cell research.

[40]  M. Horiuchi,et al.  Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. , 1999, Hypertension.

[41]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[42]  J. Sadoshima,et al.  Critical Role of the AT1 Receptor Subtype , 2005 .

[43]  H. Matsubara,et al.  Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. , 1998, Circulation research.

[44]  P. Hornsby,et al.  Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis , 1996, The Journal of cell biology.

[45]  H. Schunkert,et al.  Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. , 1991, Circulation research.

[46]  C. Stewart,et al.  Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populations. , 1991, Cytometry.