Molecular mechanisms and cellular effects of glucocorticosteroids.

[1]  I. Adcock,et al.  Update on glucocorticoid action and resistance. , 2006, The Journal of allergy and clinical immunology.

[2]  P. J. Barnes,et al.  Corticosteroid effects on cell signalling , 2006, European Respiratory Journal.

[3]  I. Adcock,et al.  Decreased histone deacetylase activity in chronic obstructive pulmonary disease. , 2005, The New England journal of medicine.

[4]  I. Adcock,et al.  Histone acetylation and deacetylation: importance in inflammatory lung diseases , 2005, European Respiratory Journal.

[5]  N. Thomson,et al.  The influence of smoking on the treatment response in patients with asthma , 2005, Current opinion in allergy and clinical immunology.

[6]  Z. Szatmáry,et al.  Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen-activated Protein (MAP) Kinase* , 2004, Journal of Biological Chemistry.

[7]  J. Dean,et al.  The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. , 2004, Cellular signalling.

[8]  T. Heinzel,et al.  Negative glucocorticoid receptor response elements and their role in glucocorticoid action. , 2004, Current pharmaceutical design.

[9]  J. Mullol,et al.  Glucocorticoid Receptor Isoforms α and β in in Vitro Cytokine-induced Glucocorticoid Insensitivity , 2004 .

[10]  C. Peterson,et al.  Histones and histone modifications , 2004, Current Biology.

[11]  P. Anderson,et al.  Post‐transcriptional regulation of proinflammatory proteins , 2004, Journal of leukocyte biology.

[12]  P. Paré,et al.  The nature of small-airway obstruction in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.

[13]  I. Adcock,et al.  Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. , 2004, The Journal of allergy and clinical immunology.

[14]  J. Cidlowski,et al.  The Origin and Functions of Multiple Human Glucocorticoid Receptor Isoforms , 2004, Annals of the New York Academy of Sciences.

[15]  Z. Rao,et al.  3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[16]  M. Garabedian,et al.  Modulation of Glucocorticoid Receptor Function via Phosphorylation , 2004, Annals of the New York Academy of Sciences.

[17]  P. Barnes,et al.  Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0. , 2004, American journal of respiratory cell and molecular biology.

[18]  I. Adcock,et al.  Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase , 2004, The Lancet.

[19]  I. Adcock,et al.  Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. , 2004, Biochemical and biophysical research communications.

[20]  M. Privalsky,et al.  The role of corepressors in transcriptional regulation by nuclear hormone receptors. , 2004, Annual review of physiology.

[21]  A. Papi,et al.  Oxidants and asthma , 2004, Thorax.

[22]  J. Mullol,et al.  Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity. , 2004, American Journal of Respiratory and Critical Care Medicine.

[23]  C. Allis,et al.  Beyond the double helix: writing and reading the histone code. , 2004, Novartis Foundation symposium.

[24]  I. Adcock,et al.  How Do Corticosteroids Work in Asthma? , 2003, Annals of Internal Medicine.

[25]  I. Adcock,et al.  Corticosteroid-insensitive asthma: molecular mechanisms. , 2003, The Journal of endocrinology.

[26]  A. Clark.  MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? , 2003, The Journal of endocrinology.

[27]  A. V. van Kuilenburg,et al.  Histone deacetylases (HDACs): characterization of the classical HDAC family. , 2003, The Biochemical journal.

[28]  Kuang-Hung Cheng,et al.  Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code , 2003, Annals of the New York Academy of Sciences.

[29]  P. Hulley,et al.  Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. , 2003, Endocrinology.

[30]  P. Shah,et al.  Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. , 2003, American journal of respiratory and critical care medicine.

[31]  J. Saklatvala,et al.  Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38 , 2002, Molecular and Cellular Biology.

[32]  I. Adcock,et al.  Expression and activity of histone deacetylases in human asthmatic airways. , 2002, American journal of respiratory and critical care medicine.

[33]  C. Peterson.  HDAC's at work: everyone doing their part. , 2002, Molecular cell.

[34]  I. Adcock,et al.  p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. , 2002, The Journal of allergy and clinical immunology.

[35]  T. Saruta,et al.  Expression and regulation of nuclear receptor coactivators in glucocorticoid action , 2002, Molecular and Cellular Endocrinology.

[36]  P. Herrlich,et al.  Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor , 2001, The EMBO journal.

[37]  I. Adcock,et al.  Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. , 2001, European journal of pharmacology.

[38]  P. Barnes,et al.  GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms. , 2001, Biochemical and biophysical research communications.

[39]  J. Ashwell,et al.  Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ* , 2001, The Journal of Biological Chemistry.

[40]  I. Adcock,et al.  Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  C. Allis,et al.  Histone acetyltransferases. , 2001, Annual review of biochemistry.

[42]  I. Adcock,et al.  Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12 , 2000, Molecular and Cellular Biology.

[43]  J. Bousquet,et al.  Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma , 2000 .

[44]  P. Barnes,et al.  Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms. , 2000, American journal of respiratory cell and molecular biology.

[45]  I. Adcock,et al.  Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. , 2000, American journal of respiratory and critical care medicine.

[46]  W. Maziak,et al.  Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. , 1999, American journal of respiratory and critical care medicine.

[47]  A. Sousa,et al.  In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation. , 1999, The Journal of allergy and clinical immunology.

[48]  J. Lafitte,et al.  Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. , 1999, American journal of respiratory and critical care medicine.

[49]  G. Piwien-Pilipuk,et al.  Inhibition of glucocorticoid receptor binding by nitric oxide. , 1999, Molecular pharmacology.

[50]  P. Barnes,et al.  Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[51]  I. Adcock,et al.  Transcription factors and asthma. , 1998, The European respiratory journal.

[52]  I. Adcock,et al.  Effect of dexamethasone on interleukin‐1β‐(IL‐1β)‐induced nuclear factor‐κB (NF‐κB) and κB‐dependent transcription in epithelial cells , 1998 .

[53]  P. Barnes,et al.  Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. , 1997, American journal of respiratory and critical care medicine.

[54]  I. Adcock,et al.  Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma , 1995, The Journal of experimental medicine.