Synthesis of some epoxy and/or N-oxy 17-picolyl and 17-picolinylidene-androst-5-ene derivatives and evaluation of their biological activity

[1]  T. Armbruster,et al.  Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives , 2007, Steroids.

[2]  E. J. Tavares da Silva,et al.  Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation. , 2005, Journal of medicinal chemistry.

[3]  R. Brueggemeier,et al.  Aromatase inhibitors in the treatment of breast cancer. , 2005, Endocrine reviews.

[4]  M. Dukes,et al.  Arimidex®: A potent and selective fourth-generation aromatase inhibitor , 2004, Breast Cancer Research and Treatment.

[5]  G. Cocconi.  First generation aromatase inhibitors — aminoglutethimide and testololactone , 2004, Breast Cancer Research and Treatment.

[6]  M. Numazawa,et al.  Aromatase Inhibition by 4β,5β-Epoxides of 16α-Hydroxyandrostenedione and Its 19-Oxygenated Analogs, Potential Precursors of Estriol Production in the Feto-Placental Unit , 2002 .

[7]  M. Numazawa,et al.  Time-dependent aromatase inactivation by 4β,5β-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs , 2002, Steroids.

[8]  M. J. D. Almeida,et al.  X-ray and deuterium labeling studies on the abnormal ring cleavages of a 5β-epoxide precursor of formestane , 2002, Steroids.

[9]  M. Sakač,et al.  New D-modified androstane derivatives as aromatase inhibitors☆ , 2001, Steroids.

[10]  V. Njar,et al.  Aromatase inhibitors and their application in breast cancer treatment☆ , 2000, Steroids.

[11]  Louis J. Farrugia,et al.  WinGX suite for small-molecule single-crystal crystallography , 1999 .

[12]  M. Numazawa,et al.  Studies directed toward a mechanistic evaluation of aromatase inhibition by androst-5-ene-7,17-dione Time-dependent inactivation by the 19-nor and 5β,6β-epoxy derivatives , 1997, Steroids.

[13]  A. Bhatnagar,et al.  Clinical use of aromatase inhibitors in the treatment of advanced breast cancer , 1997, The Journal of Steroid Biochemistry and Molecular Biology.

[14]  H. Adlercreutz.  Phytoestrogens: epidemiology and a possible role in cancer protection. , 1995, Environmental health perspectives.

[15]  M. Numazawa,et al.  Competing pathway involved in allylic acetoxylation of androst-5-en-17-one, and oxidation of allylic alcohols with chromium oxides , 1995, Steroids.

[16]  Y. Ito,et al.  Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. , 1994, Endocrine reviews.

[17]  M. Lang,et al.  Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[18]  Y. Abul-Hajj,et al.  Aromatase inhibition by flavonoids , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[19]  D. Scudiero,et al.  New colorimetric cytotoxicity assay for anticancer-drug screening. , 1990, Journal of the National Cancer Institute.

[20]  M. Reed,et al.  Aromatase activity in normal breast and breast tumor tissues: In vivo and in vitro studies , 1987, Steroids.