IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

[1]  W. Paul,et al.  An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[2]  F. Finkelman,et al.  Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. , 1997, Annual review of immunology.

[3]  S. Galli,et al.  Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. , 1997, The Journal of clinical investigation.

[4]  S. Akira,et al.  Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. , 1996, Journal of immunology.

[5]  J. Renauld,et al.  A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 , 1996, Molecular and cellular biology.

[6]  J. Lélias,et al.  Cloning and Characterization of a Specific Interleukin (IL)-13 Binding Protein Structurally Related to the IL-5 Receptor α Chain* , 1996, The Journal of Biological Chemistry.

[7]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[8]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[9]  H. K. Lee,et al.  Anti-IL-4 antibody inhibits antigen specific IgE response but fails to prevent chicken gamma globulin-induced active systemic anaphylaxis: evidence for the involvement of IgG antibodies. , 1996, Journal of Korean medical science.

[10]  S. Colgan,et al.  Interleukin-4 and Interleukin-13 Differentially Regulate Epithelial Chloride Secretion (*) , 1996, The Journal of Biological Chemistry.

[11]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.

[12]  W. Paul,et al.  IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain. , 1996, Immunity.

[13]  W. Paul,et al.  Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. , 1996, Immunity.

[14]  J. G. Zhang,et al.  Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[15]  R. Puri,et al.  Receptors for Interleukin (IL)-4 Do Not Associate with the Common γChain, and IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells (*) , 1995, The Journal of Biological Chemistry.

[16]  M. White,et al.  The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction. , 1995, Blood.

[17]  William Arbuthnot Sir Lane,et al.  Role of IRS-2 in insulin and cytokine signalling , 1995, Nature.

[18]  J. Johnston,et al.  Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Banchereau,et al.  The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor (*) , 1995, The Journal of Biological Chemistry.

[20]  F. Finkelman,et al.  IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice. , 1995, Journal of immunology.

[21]  R. Puri,et al.  Receptor for Interleukin 13 , 1995, The Journal of Biological Chemistry.

[22]  T. Malek,et al.  Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. , 1995, Journal of immunology.

[23]  A. Duschl,et al.  Both Interleukin 4 and Interleukin 13 Induce Tyrosine Phosphorylation of the 140-kDa Subunit of the Interleukin 4 Receptor (*) , 1995, The Journal of Biological Chemistry.

[24]  E. Rieber,et al.  Human interleukin‐13 activates the interleukin‐4‐dependent transcription factor NF‐IL4 sharing a DNA binding motif with an interferon‐γ‐induced nuclear binding factor , 1994, FEBS letters.

[25]  F. Finkelman,et al.  Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites , 1994, The Journal of experimental medicine.

[26]  F. Finkelman,et al.  Toxocara canis: failure to find IgE receptors (Fc epsilon R) on eosinophils from infected mice suggests that murine eosinophils do not kill helminth larvae by an IgE-dependent mechanism. , 1994, Experimental parasitology.

[27]  F. Finkelman,et al.  Cytokine-mediated regulation of chronic intestinal helminth infection , 1994, The Journal of experimental medicine.

[28]  J. D. de Vries,et al.  Interleukin 13 elicits a subset of the activities of its close relative interleukin 4 , 1994, Stem cells.

[29]  J. D. de Vries,et al.  Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. , 1994, Immunology today.

[30]  F. Finkelman,et al.  IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. , 1993, Journal of immunology.

[31]  F. Finkelman,et al.  Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. , 1993, Journal of immunology.

[32]  G. Zurawski,et al.  Receptors for interleukin‐13 and interleukin‐4 are complex and share a novel component that functions in signal transduction. , 1993, The EMBO journal.

[33]  Martin Bachmann,et al.  Disruption of the murine IL-4 gene blocks Th2 cytokine responses , 1993, Nature.

[34]  K. Rajewsky,et al.  Generation and analysis of interleukin-4 deficient mice. , 1991, Science.

[35]  F. Finkelman,et al.  Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. , 1991, Journal of immunology.

[36]  W. Paul,et al.  Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[37]  R. Bell,et al.  A role for IgE in intestinal immunity. Expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes. , 1991, Journal of immunology.

[38]  D. Friend,et al.  Monoclonal antibodies block murine IL-4 receptor function. , 1990, Journal of immunology.

[39]  R. Kaufman.  Vectors used for expression in mammalian cells. , 1990, Methods in enzymology.

[40]  Alan I. Alpert,et al.  The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms , 1989, Cell.

[41]  M. Kehry,et al.  Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[42]  David A. Harris,et al.  Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor , 1989, Nature.

[43]  N. Inagaki,et al.  Comparative study of 1.5-hour and 48-hour homologous passive cutaneous anaphylaxis in the mouse ear. , 1989, Journal of pharmacobio-dynamics.

[44]  F. Finkelman,et al.  The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. , 1988, Journal of immunology.

[45]  J. Appleton,et al.  Characterization of the immune mediator of rapid expulsion of Trichinella spiralis in suckling rats. , 1987, Immunology.

[46]  T. Mosmann,et al.  Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies , 1987, The Journal of experimental medicine.

[47]  W. Paul,et al.  Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1 , 1985, The Journal of experimental medicine.

[48]  Z. Eshhar,et al.  Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE , 1984, European journal of immunology.

[49]  P. Marrack,et al.  Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. , 1983, Journal of immunology.

[50]  F. Finkelman,et al.  Polyclonal activation of the murine immune system by an antibody to IgD III. Ontogeny , 1983, European journal of immunology.

[51]  F. Finkelman,et al.  Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG. , 1982, Journal of immunology.

[52]  G. Köhler,et al.  Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Z. Eshhar,et al.  Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. , 1980, Journal of immunology.

[54]  D. Hockley,et al.  Effects of immunity of Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction, and morphology. , 1968, The Journal of parasitology.