Elevated serum levels of soluble vascular cell adhesion molecule‐1 (sVCAM‐1) closely reflect tumour burden in chronic B‐lymphocytic leukaemia

The present study is the first to report elevated serum levels of soluble (s)VCAM‐1 in B‐cell chronic lymphocytic leukaemia (B‐CLL). A large cohort of 106 untreated patients was studied. sVCAM‐1 was compared to known prognostic serum markers (soluble (s)ICAM‐1; lactate dehydrogenase, LDH; sCD23; thymidine kinase, TK; β2microglobulin, β2m). The serum levels of sVCAM‐1 reflected tumour burden as expressed by Binet/Rai stages more closely than any other marker. sVCAM‐1 also reflected the kinetics of the disease as revealed by lymphocyte doubling time. sVCAM‐1 was the only one of the studied markers which showed elevated levels in smouldering disease compared to controls. sVCAM‐1, sICAM‐1 and sCD23 (but not LDH, TK, β2m) separated smouldering from non‐smouldering B‐CLL. Only sICAM‐1, sCD23 and TK added independent prognostic information for survival to that of stage and lymphocyte doubling time.

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