What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

[1]  S. Nagao,et al.  Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials. , 2024, Organic letters.

[2]  M. Ono,et al.  First‐in‐human study of E7130 (a tumor microenvironment‐ameliorating microtubule inhibitor) in patients with advanced solid tumors: Primary results of the dose‐escalation part , 2023, Cancer.

[3]  Y. Kishi,et al.  Total Synthesis of Halistatins 1 and 2. , 2020, Journal of the American Chemical Society.

[4]  T. Owa,et al.  A landmark in drug discovery based on complex natural product synthesis , 2019, Scientific Reports.

[5]  Shuji Yamashita,et al.  Unified Synthesis of Right Halves of Halichondrins A-C. , 2017, The Journal of organic chemistry.

[6]  Y. Kishi,et al.  Stereocontrolled Synthesis of Left Halves of Halichondrins. , 2017, The Journal of organic chemistry.

[7]  Qiaoyi Wang,et al.  Zirconium/Nickel-Mediated One-Pot Ketone Synthesis. , 2017, Angewandte Chemie.

[8]  Y. Kishi,et al.  Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel-Mediated One-Pot Ketone Synthesis as the Final Coupling Reaction. , 2017, Angewandte Chemie.

[9]  Y. Kishi,et al.  Total synthesis of halichondrin A, the missing member in the halichondrin class of natural products. , 2014, Journal of the American Chemical Society.

[10]  M. Kubota,et al.  Process Development of Halaven®: Synthesis of the C14–C35 Fragment via Iterative Nozaki–Hiyama–Kishi Reaction–Williamson Ether Cyclization , 2013, Synlett.

[11]  M. Kubota,et al.  Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones , 2013, Synlett.

[12]  M. Schnaderbeck,et al.  Process Development of Halaven®: Synthesis of the C1–C13 Fragment from d-(–)-Gulono-1,4-lactone , 2013, Synlett.

[13]  D. Weix,et al.  Synthesis of functionalized dialkyl ketones from carboxylic acid derivatives and alkyl halides. , 2012, Organic letters.

[14]  P. Brémond,et al.  Total synthesis of halichondrin C. , 2012, Journal of the American Chemical Society.

[15]  Haibing Guo,et al.  New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: double-inversion approach. , 2009, Journal of the American Chemical Society.

[16]  D. Urabe,et al.  New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: reductive cyclization and oxy-Michael cyclization approaches. , 2009, Journal of the American Chemical Society.

[17]  Xiang Liu,et al.  Toolbox approach to the search for effective ligands for catalytic asymmetric Cr-mediated coupling reactions. , 2009, Journal of the American Chemical Society.

[18]  S. J. Hickford,et al.  Antitumour polyether macrolides: four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp. , 2009, Bioorganic & medicinal chemistry.

[19]  Melvin J. Yu,et al.  Structurally simplified macrolactone analogues of halichondrin B. , 2004, Bioorganic & medicinal chemistry letters.

[20]  Lynda Tremblay,et al.  Macrocyclic ketone analogues of halichondrin B. , 2004, Bioorganic & medicinal chemistry letters.

[21]  R. Lill,et al.  Antitumor Polyether Macrolides: New and Hemisynthetic Halichondrins from the New Zealand Deep-Water Sponge Lissodendoryx sp. , 1997 .

[22]  F. Gao,et al.  Isolation and Structure of Halistatin 1 from the Eastern Indian Ocean Marine Sponge Phakellia carteri , 1993 .

[23]  Craig J. Forsyth,et al.  Total synthesis of halichondrin B and norhalichondrin B , 1992 .

[24]  M. Boyd,et al.  Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp. , 1991, Journal of medicinal chemistry.

[25]  D. Uemura,et al.  Halichondrins - antitumor polyether macrolides from a marine sponge , 1986 .

[26]  J. Tanaka,et al.  Norhalichondrin A: an antitumor polyether macrolide from a marine sponge , 1985 .