Changes in motor commands, as shown by changes in perceived heaviness, during partial curarization and peripheral anaesthesia in man

1. The centrally generated ‘effort’ or direct voluntary command to motoneurones required to lift a weight was studied using a simple weight‐matching task when the muscles lifting a reference weight were weakened. This centrally generated input to motoneurones was increased when the lifting muscles were partially paralysed with curare or decamethonium as judged by the increased perceived heaviness of a reference weight lifted by the weakened muscles.

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