Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)

Abstract Background. The management of cardiovascular risk factors is important for prevention of atherosclerotic cardiovascular diseases (ACVD). Visceral fat accumulation plays an important role in the clustering of cardiovascular risk factors, leading to ACVD. The present study investigated the gender- and age-specific relationship between obesity-related cardiovascular risk factor accumulation and computed tomography (CT)-measured fat distribution in a large-scale Japanese general population. Methods and results. Fat distribution was measured on CT scans in 12,443 subjects (males/females = 10,080/2,363), who underwent medical health check-up at 9 centers in Japan. The investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure. Visceral fat area (VFA) for all males and old females showed almost symmetric distribution, while that of young females showed skewed distribution with a marked left shift. Only a small proportion of young females had large visceral fat and cardiovascular risk accumulation. The mean number of risk factors exceeded 1.0 at around 100 cm2 for VFA in all groups, irrespective of gender, age (cut-off age 55), and BMI (cut-off BMI 25 kg/m2). Conclusions. In this large-scale Japan-wide general population study, an absolute VFA value of about 100 cm2 equated with obesity-related cardiovascular risk factor accumulation, irrespective of gender, age, and BMI. Clinical trial registration information. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000002780&language=E.

[1]  A. Kissebah,et al.  Relation of body fat distribution to metabolic complications of obesity. , 1982, The Journal of clinical endocrinology and metabolism.

[2]  Y. Matsuzawa,et al.  Close correlation of intra-abdominal fat accumulation to hypertension in obese women. , 1990, Hypertension.

[3]  Y. Matsuzawa,et al.  A novel technique for the determination of body fat by computed tomography. , 1983, International journal of obesity.

[4]  M. Yamagishi,et al.  Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome. , 2008, Diabetes research and clinical practice.

[5]  Y. Matsuzawa,et al.  Analysis of an expression profile of genes in the human adipose tissue. , 1997, Gene.

[6]  L. Kuller,et al.  Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study , 2006, International Journal of Obesity.

[7]  S. Kaneko,et al.  Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities. , 2009, Metabolism: clinical and experimental.

[8]  S. Tarui,et al.  Classification of Obesity with Respect to Morbidity , 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[9]  N. Kaplan.  The Deadly Quartet: Upper-Body Obesity, Glucose Intolerance, Hypertriglyceridemia, and Hypertension , 1989 .

[10]  T. Funahashi,et al.  Metabolic syndrome: Clinical concept and molecular basis , 2007, Annals of medicine.

[11]  R. Vasan,et al.  Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot? , 2009, Diabetes Care.

[12]  T Nakamura,et al.  Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. , 1994, Atherosclerosis.

[13]  L. Cominacini,et al.  Relation of body fat distribution in men and degree of coronary narrowings in coronary artery disease. , 1992, The American journal of cardiology.

[14]  J. Vague.  Sexual differentiation; Factor determining forms of obesity. , 1947 .

[15]  R. Hoffmann,et al.  Adiposity, fat distribution, and cardiovascular risk. , 1989, Annals of internal medicine.

[16]  Y. Matsuzawa.  Establishment of a concept of visceral fat syndrome and discovery of adiponectin , 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[17]  S. Kihara,et al.  Visceral fat accumulation as an important risk factor for obstructive sleep apnoea syndrome in obese subjects , 1997, Journal of internal medicine.

[18]  Takashi Miyawaki,et al.  Metabolic syndrome in Japanese diagnosed with visceral fat measurement by computed tomography , 2005 .

[19]  J. Després,et al.  International Day for the Evaluation of Abdominal Obesity (IDEA): A Study of Waist Circumference, Cardiovascular Disease, and Diabetes Mellitus in 168 000 Primary Care Patients in 63 Countries , 2007, Circulation.

[20]  S. Yamashita,et al.  Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women. , 1996, Hypertension.

[21]  Eiji Oda,et al.  New criteria for 'obesity disease' in Japan. , 2002, Circulation journal : official journal of the Japanese Circulation Society.

[22]  Udo Hoffmann,et al.  Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study , 2007, Circulation.

[23]  G Scott Gazelle,et al.  CT screening: a trade-off of risks, benefits, and costs. , 2003, The Journal of clinical investigation.

[24]  Y. Matsuzawa,et al.  Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[25]  Y. Matsuzawa,et al.  Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. , 1987, Metabolism: clinical and experimental.

[26]  P. Björntorp,et al.  Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. , 1984, British medical journal.

[27]  R. Collins,et al.  Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins , 2005, The Lancet.

[28]  Y. Matsuzawa,et al.  Correlation of intraabdominal fat accumulation and left ventricular performance in obesity. , 1989, The American journal of cardiology.

[29]  T. Funahashi,et al.  Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers. , 2010, Journal of atherosclerosis and thrombosis.

[30]  L H Kuller,et al.  Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study , 2012, International Journal of Obesity.

[31]  P. Björntorp.  Classification of obese patients and complications related to the distribution of surplus fat. , 1987, The American journal of clinical nutrition.

[32]  R. Santos,et al.  Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography. , 2010, Atherosclerosis.