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The Immune Response is a new, and unique reference work covering basic and clinical principles in an up-to-date, and comprehensive fashion. Over the course of thirty chapters, written by extremely high profile authors, the broad scope of modern immunology is presented. The book is beautifully illustrated, with four-color figures and plates throughout. It is an invaluable resource for lecturers and a vital reference for research scientists throughout the life and medical sciences. * Current and thorough reference written by extremely high profile and respected authors * Dr. Tak Mak led the group that was the first to identify and clone human immune-system T-cell receptors in 1984 * An impressive array of basic and fundamental immunology questions are answered * Terminology is put into historical context that allows a fuller understanding of the area under discussion * Unique 'single voice' delivery of key subjects in immunology offer consistency of definition as complex concepts recur from chapter-to-chapter " …straight forward style…crystal clear definitions of complex immunological concepts... Uncomplicated style effortless for the reader to move from one section to the next, comfortable, unforced learning experience… " "...chapters are a delight to read...I {also} like the format of presentation with boxes for the specialists and plenty of illustration ... "…very well written; it will be easily accessible to a broad readership, including undergraduate and graduate students…" "...this textbook from Mak and Saunders is very timely, reads very well, and should be of great interest to those wanting to get a start in understanding Immunology..." Abstract The Israeli isolate of Tomato yellow leaf curl geminivirus (TYLCV-Is) is a major tomato pathogen, causing extensive crop losses both in the New and Old World. Surprisingly, however, little is known about the molecular mechanisms of TYLCV-Is interactions with tomato cells. Here, we have identified a TYLCV-Is protein, V2, which acts as a suppressor of RNA silencing and which is unrelated to presently known viral suppressors. Specifically, V2, but not other proteins of TYLCV-Is, inhibited RNA silencing of a reporter transgene, GFP. This inhibition elevated the cellular levels of the GFP transcript and the GFP protein, but it had no apparent effect on the accumulation of GFP-specific short interfering RNAs (siRNAs), suggesting that TYLCV-Is V2 targets a step in the RNA silencing pathway which is subsequent to the Dicer-mediated cleavage of dsRNA. Visualization of the sub-cellular localization of TYLCV-Is V2 in plant protoplasts and tissues showed that this …