Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 expression.

[1]  S. Thibodeau,et al.  Heterogenous MSH6 Loss Is a Result of Microsatellite Instability Within MSH6 and Occurs in Sporadic and Hereditary Colorectal and Endometrial Carcinomas , 2015, The American journal of surgical pathology.

[2]  P. Saetrom,et al.  Cell cycle regulation of human DNA repair and chromatin remodeling genes. , 2015, DNA repair.

[3]  N. Petrelli,et al.  A review of the evolution of systemic chemotherapy in the management of colorectal cancer. , 2015, Clinical colorectal cancer.

[4]  Y. Niv,et al.  How reliable is immunohistochemical staining for DNA mismatch repair proteins performed after neoadjuvant chemoradiation? , 2014, Human pathology.

[5]  A. Bojesen,et al.  Heterogenous mismatch-repair status in colorectal cancer , 2014, Diagnostic Pathology.

[6]  R. Pai,et al.  Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach. , 2013, Human pathology.

[7]  M. Ladanyi,et al.  Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency , 2013, Modern Pathology.

[8]  J. Weitzel,et al.  Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  S. Syngal,et al.  Screening patients with colorectal cancer for Lynch syndrome: what are we waiting for? , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  A. Krasinskas,et al.  Challenging cases encountered in colorectal cancer screening for Lynch syndrome reveal novel findings: nucleolar MSH6 staining and impact of prior chemoradiation therapy. , 2011, Human pathology.

[11]  J. Baranda,et al.  Capecitabine versus 5-fluorouracil in colorectal cancer: where are we now? , 2011 .

[12]  R. Yantiss,et al.  Neoadjuvant Therapy Induces Loss of MSH6 Expression in Colorectal Carcinoma , 2010, The American journal of surgical pathology.

[13]  K. Gravdal,et al.  Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis , 2009, British Journal of Cancer.

[14]  H T Lynch,et al.  Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications , 2009, Clinical genetics.

[15]  Robin L. Jones,et al.  The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer , 2009, Breast Cancer Research and Treatment.

[16]  M. Ligtenberg,et al.  Interpretation of Immunohistochemistry for Mismatch Repair Proteins is Only Reliable in a Specialized Setting , 2008, The American journal of surgical pathology.

[17]  D. Chang,et al.  The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside , 2007, Familial Cancer.

[18]  D. Klimstra,et al.  The utility of immunohistochemical detection of DNA mismatch repair gene proteins , 2004, Virchows Archiv.

[19]  B. Leggett,et al.  Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[20]  M. Biondi,et al.  Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[21]  T. Kunkel,et al.  Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes* , 2000, The Journal of Biological Chemistry.

[22]  G. Marsischky,et al.  Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. , 1996, Genes & development.