Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response.
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P. Martiat | L. Willems | A. Kentos | L. Lagneaux | D. Bron | B. Stamatopoulos | N. Meuleman | N. Gillet | A. Delforge | M. Dejeneffe | M. Massy
[1] G. Romano,et al. Selective inhibition of PED protein expression sensitizes B‐cell chronic lymphocytic leukaemia cells to TRAIL‐induced apoptosis , 2007, International journal of cancer.
[2] Jihong Chen,et al. Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B , 2006, Molecular Cancer.
[3] Michael Rytting,et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. , 2006, Blood.
[4] Satoshi Inoue,et al. Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. , 2006, Cancer research.
[5] B. Hylander,et al. Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL , 2006, Molecular Cancer Therapeutics.
[6] D. Schrump,et al. Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. , 2006, Neoplasia.
[7] C. Cho,et al. Hydroxychloroquine potentiates Fas‐mediated apoptosis of rheumatoid synoviocytes , 2006, Clinical and experimental immunology.
[8] Tao Liu,et al. Histone deacetylase inhibitors: multifunctional anticancer agents. , 2006, Cancer treatment reviews.
[9] S. O'brien,et al. Initial therapy for patients with chronic lymphocytic leukemia. , 2006, Seminars in oncology.
[10] J. Vávrová,et al. Effect of valproic acid and antiapoptotic cytokines on differentiation and apoptosis induction of human leukemia cells. , 2006, General physiology and biophysics.
[11] Afshin Samali,et al. TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt , 2006, British Journal of Cancer.
[12] E. Rowinsky. Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[13] R. Fanin,et al. Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B‐CLL) cells , 2005, Journal of cellular physiology.
[14] A. Burny,et al. Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[15] G. Cohen,et al. Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1 , 2005, Cell Death and Differentiation.
[16] R. Blaheta,et al. Evolving anticancer drug valproic acid: Insights into the mechanism and clinical studies , 2005, Medicinal research reviews.
[17] M. Andreeff,et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[18] B. Rotoli,et al. Induction of CD95 upregulation does not render chronic lymphocytic leukemia B-cells susceptible to CD95-mediated apoptosis. , 2005, Immunology letters.
[19] S. Inoue,et al. Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies , 2004, Cell Death and Differentiation.
[20] C. Croce,et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[21] O. Legrand,et al. Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1 , 2004, Leukemia.
[22] M. Tallman,et al. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. , 2004, Leukemia research.
[23] M. Grever,et al. The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells , 2004, Leukemia.
[24] P. Atadja,et al. Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells , 2004, Cancer Research.
[25] R. Kuefer,et al. Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer , 2004, British Journal of Cancer.
[26] E. Taubøll,et al. Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7 , 2004, Molecular and Cellular Endocrinology.
[27] Adrian Wiestner,et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia , 2004, The Lancet.
[28] Jian Kang,et al. Chemical sensitization and regulation of TRAIL‐induced apoptosis in a panel of B‐lymphocytic leukaemia cell lines , 2003, British journal of haematology.
[29] M. Andreeff,et al. Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[30] M. Grever,et al. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. , 2003, Blood.
[31] Adrian Wiestner,et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. , 2003, Blood.
[32] G. Cohen,et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia , 2002, Oncogene.
[33] K. Sano,et al. Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways. , 2002, Leukemia research.
[34] S. Bates,et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[35] J. Byrd,et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. , 2002, Blood.
[36] Ping Zhu,et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.
[37] P. Marks,et al. Histone deacetylases and cancer: causes and therapies , 2001, Nature Reviews Cancer.
[38] V. Richon,et al. Histone deacetylase inhibitors as new cancer drugs , 2001, Current opinion in oncology.
[39] M. Guenther,et al. Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.
[40] P. Marks,et al. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. , 2000, Journal of the National Cancer Institute.
[41] Xiaodong Wang,et al. Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway* , 2000, The Journal of Biological Chemistry.
[42] T J Hamblin,et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. , 1999, Blood.
[43] N. Chiorazzi,et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. , 1999, Blood.
[44] L. Lagneaux,et al. Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells , 1998 .
[45] K. Struhl. Histone acetylation and transcriptional regulatory mechanisms. , 1998, Genes & development.
[46] J. Cinatl,et al. Sodium valproate inhibits in vivo growth of human neuroblastoma cells. , 1997, Anti-cancer drugs.
[47] D. P. Bentley,et al. Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. , 1997, British Journal of Cancer.
[48] D. Oscier,et al. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. , 1997, Blood.
[49] R. Levy,et al. Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. , 1992, Molecular immunology.
[50] I Nicoletti,et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. , 1991, Journal of immunological methods.
[51] N. Chiorazzi,et al. mechanisms of disease Chronic Lymphocytic Leukemia , 2010 .
[52] Mark J. Thomas,et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis , 1981, Cancer.
[53] A. Teufel,et al. Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. , 2006, Oncology reports.
[54] A. Zelenetz,et al. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[55] C. Steidl,et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all‐trans retinoic acid in patients with acute myeloid leukemia , 2006, Cancer.
[56] K. Watanabe,et al. Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP , 2005, Cell Death and Differentiation.
[57] P. Atadja,et al. Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. , 2004, Haematologica.
[58] J. Byrd,et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). , 2003, Blood.
[59] Vigushin Dm,et al. Histone deacetylase inhibitors in cancer treatment. , 2002 .