Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

Peter Barnes and colleagues show that corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that suppress Th2 cytokine expression. This novel mechanism of corticosteroid action may help explain the efficacy of corticosteroids in allergic diseases.

[1]  D. DeFranco,et al.  Glucocorticoid receptor physiology , 2007, Reviews in Endocrine and Metabolic Disorders.

[2]  Rhian F. Walther,et al.  An Active Nuclear Retention Signal in the Glucocorticoid Receptor Functions as a Strong Inducer of Transcriptional Activation* , 2007, Journal of Biological Chemistry.

[3]  Ian M. Adcock,et al.  Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-31 , 2007, The Journal of Immunology.

[4]  S. Zahler,et al.  MAPK phosphatase‐1 represents a novel anti‐inflammatory target of glucocorticoids in the human endothelium , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  D. Umetsu,et al.  The regulation of allergy and asthma , 2006, Immunological reviews.

[6]  P. Barnes.  How corticosteroids control inflammation: Quintiles Prize Lecture 2005 , 2006, British journal of pharmacology.

[7]  W. Pratt,et al.  Chaperoning of glucocorticoid receptors. , 2006, Handbook of experimental pharmacology.

[8]  W. Paul,et al.  GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors , 2006, Cell Research.

[9]  S. Durham,et al.  Single dose topical corticosteroid inhibits IL‐5 and IL‐13 in nasal lavage following grass pollen challenge , 2005, Allergy.

[10]  J. Cidlowski,et al.  Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. , 2005, The New England journal of medicine.

[11]  Malcolm Johnson,et al.  Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. , 2005, American journal of respiratory and critical care medicine.

[12]  C. Hawrylowicz,et al.  Repression of Interleukin-5 Transcription by the Glucocorticoid Receptor Targets GATA3 Signaling and Involves Histone Deacetylase Recruitment* , 2005, Journal of Biological Chemistry.

[13]  Minoru Yoshida,et al.  HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. , 2005, Molecular cell.

[14]  F. Holsboer,et al.  FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells* , 2005, Journal of Biological Chemistry.

[15]  M. Galigniana,et al.  Cyclophilin-A Is Bound through Its Peptidylprolyl Isomerase Domain to the Cytoplasmic Dynein Motor Protein Complex* , 2004, Journal of Biological Chemistry.

[16]  A. Masuda,et al.  The Interaction between GATA Proteins and Activator Protein-1 Promotes the Transcription of IL-13 in Mast Cells1 , 2004, The Journal of Immunology.

[17]  D. Goldfarb,et al.  Importin α: A multipurpose nuclear-transport receptor , 2004 .

[18]  Maki Ukai-Tadenuma,et al.  Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci* , 2004, Journal of Biological Chemistry.

[19]  M. Kawata,et al.  Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway. , 2004, Biochimica et biophysica acta.

[20]  K. Yamamoto,et al.  Importin 7 and Importin / Importin Are Nuclear Import Receptors for the Glucocorticoid Receptor , 2003 .

[21]  S. Pai,et al.  GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Goldfarb,et al.  Importin alpha: a multipurpose nuclear-transport receptor. , 2004, Trends in cell biology.

[23]  K. Yamamoto,et al.  Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. , 2004, Molecular biology of the cell.

[24]  P. Krammer,et al.  Regulation of IL4 gene expression by T cells and therapeutic perspectives , 2003, Nature Reviews Immunology.

[25]  J. Saklatvala,et al.  Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38 , 2002, Molecular and Cellular Biology.

[26]  K. Arai,et al.  Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development , 2002, The Journal of Immunology.

[27]  P. Romeo,et al.  Interleukin-13 Gene Expression Is Regulated by GATA-3 in T Cells , 2002, The Journal of Biological Chemistry.

[28]  Jae-Won Oh,et al.  The effect of disodium cromoglycate, budesonide, and cyclosporin A on interleukin-4, interleukin-5, and interleukin-13 secretions in Der p I-stimulated T cells from house dust mite-sensitive atopic and nonatopic individuals. , 2002, Allergy and asthma proceedings.

[29]  M. Kubo,et al.  The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response. , 2002, International immunology.

[30]  V. Mordvinov,et al.  GATA-3 Has Dual Regulatory Functions in Human Interleukin-5 Transcription* , 2001, The Journal of Biological Chemistry.

[31]  I. Adcock,et al.  p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids , 2001, The Journal of Biological Chemistry.

[32]  M. Neurath,et al.  Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression , 2001, The Journal of experimental medicine.

[33]  R. Flavell,et al.  Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. , 2001, Immunity.

[34]  I. Adcock,et al.  Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12 , 2000, Molecular and Cellular Biology.

[35]  R. Egan,et al.  Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors. , 2000, The Journal of allergy and clinical immunology.

[36]  P. Daley-Yates,et al.  Comparison of the Systemic Availability of Fluticasone Propionate in Healthy Volunteers and Patients with Asthma , 2000, Clinical pharmacokinetics.

[37]  A. Ray,et al.  Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. , 1999, The Journal of clinical investigation.

[38]  D. H. Zhang,et al.  Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. , 1999, Immunity.

[39]  R. Haché,et al.  Discrimination between NL1- and NL2-Mediated Nuclear Localization of the Glucocorticoid Receptor , 1999, Molecular and Cellular Biology.

[40]  D. H. Zhang,et al.  Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. , 1998, Journal of immunology.

[41]  O. Kaminuma,et al.  IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. , 1995, International immunology.

[42]  T. Werner,et al.  MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. , 1995, Nucleic acids research.

[43]  P. Romeo,et al.  Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains , 1994, Molecular and cellular biology.

[44]  I. Adcock,et al.  Anti-inflammatory actions of steroids: molecular mechanisms. , 1993, Trends in pharmacological sciences.

[45]  K. Yamamoto,et al.  Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor. , 1987, The EMBO journal.