Synchrotron X-ray synthesized gold nanoparticles for tumor therapy

Highly concentrated gold nanoparticles (20 ± 5 nm) were produced by an x‐ray irradiation method. The particles were then examined for the interactions between gold and tumor cells under x‐ray radiation conditions. The biological effects of gold nanoparticles were investigated in terms of the internalization, cytotoxicity and capability to enhance x‐ray radiotherapy. The results of this investigation indicated that x‐ray derived gold nanoparticles were nontoxic to CT‐26 cell line and immobilized within cytoplasm. The irradiation experiments provided further evidence that gold nanoparticles were capable of enhancing the efficiency of radiotherapy.