Acute Pancreatitis in Chronic Dialysis Patients

Abstract The annual incidence of acute pancreatitis (AP) ranges from 4.9 to 73.4 cases per 100,000 worldwide. Patients with end-stage renal disease on dialysis have an increased risk for developing AP compared with patients without renal disease. In addition to the general population risk factors, there are factors related to renal insufficiency and dialysis process that might predispose to AP in this population. Clinical features and diagnosis are the same as those in patients without renal failure; however, amylase and lipase levels should be interpreted cautiously as they might be falsely elevated in renal failure. In this article, we will describe the risk factors that are exclusive to this population. In addition, we will also focus on the laboratory indices and clinical features that are unique to this population with patients with end-stage renal disease.

[1]  Chih-Chiang Chien,et al.  Epidemiology and outcome of acute pancreatitis in end-stage renal disease dialysis patients: a 10-year national cohort study , 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[2]  V. Chopra,et al.  Early Versus Delayed Feeding in Patients With Acute Pancreatitis , 2017, Annals of Internal Medicine.

[3]  W. F. Wright Cullen Sign and Grey Turner Sign Revisited , 2016, The Journal of the American Osteopathic Association.

[4]  Chen-Yang Hsu,et al.  Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study , 2013, PloS one.

[5]  Dhiraj Yadav,et al.  The epidemiology of pancreatitis and pancreatic cancer. , 2013, Gastroenterology.

[6]  Colin D Johnson,et al.  Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus , 2012, Gut.

[7]  R. Thoeni The revised Atlanta classification of acute pancreatitis: its importance for the radiologist and its effect on treatment. , 2012, Radiology.

[8]  D. Tarng,et al.  Risk factors associated with elevated serum pancreatic amylase levels during hemodialysis , 2011, Hemodialysis international. International Symposium on Home Hemodialysis.

[9]  L. Brenner,et al.  Pancreatitis following administration of iodixanol in patients on hemodialysis: a pilot study. , 2010, Clinical Nephrology.

[10]  H. Szerlip,et al.  Two cases of iodixanol-induced pancreatitis , 2008, NDT plus.

[11]  P. Maisonneuve,et al.  Frequency and severity of acute pancreatitis in chronic dialysis patients. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[12]  C. Camargo,et al.  Increasing United States hospital admissions for acute pancreatitis, 1988-2003. , 2007, Annals of epidemiology.

[13]  D. Yadav,et al.  Trends in the Epidemiology of the First Attack of Acute Pancreatitis: A Systematic Review , 2006, Pancreas.

[14]  G. Divine,et al.  Acute Pancreatitis in Patients on Chronic Peritoneal Dialysis: An Increased Risk? , 2005, The American Journal of Gastroenterology.

[15]  N. Merrett,et al.  Serum elastase in the diagnosis of acute pancreatitis: a prospective study , 2005, ANZ journal of surgery.

[16]  K. Taketa,et al.  Pancreatic-type hyperamylasemia in end-stage renal disease , 1989, Digestive Diseases and Sciences.

[17]  B. Grabensee,et al.  Dialysis with icodextrin interferes with measurement of serum α‐amylase activity , 2002 .

[18]  Chaw-Fung Jiang,et al.  Serum level of amylase and lipase in various stages of chronic renal insufficiency. , 2002, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.

[19]  Paul V. Desmond,et al.  Prospective assessment of magnetic resonance cholangiopancreatography for noninvasive imaging of the biliary tree. , 2002, Gastrointestinal endoscopy.

[20]  G. Sakorafas,et al.  Ischemia/Reperfusion-Induced Pancreatitis , 2000, Digestive Surgery.

[21]  J. Ferwerda,et al.  Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome, and possible aetiology , 2000, Gut.

[22]  A. Grzegorzewska,et al.  Polyglucose dialysis solution influences serum activity of amylase and of lipase differently. , 2000, Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.

[23]  J. Lavelle,et al.  Mortality from acute pancreatitis , 1999, International journal of pancreatology : official journal of the International Association of Pancreatology.

[24]  P. Lankisch,et al.  Underestimation of acute pancreatitis: patients with only a small increase in amylase/lipase levels can also have or develop severe acute pancreatitis , 1999, Gut.

[25]  T. Baron,et al.  Pancreatic fluid collections prior to intervention: evaluation with MR imaging compared with CT and US. , 1997, Radiology.

[26]  M. Soresi,et al.  Influence of haemodialysis on lipase activity. , 1997, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

[27]  T. Shibasaki,et al.  Significance of serum lipase in patients undergoing hemodialysis. , 1996, American journal of nephrology.

[28]  M. Ishida,et al.  Serum levels of six pancreatic enzymes as related to the degree of renal dysfunction. , 1995, The American journal of gastroenterology.

[29]  J. Deddens,et al.  Pancreatitis in Patients with End‐Stage Renal Disease , 1994, Medicine.

[30]  R. Krediet,et al.  Acute pancreatitis during CAPD in The Netherlands. , 1993, Nephrology, Dialysis and Transplantation.

[31]  J. Lewis,et al.  Serum amylase in patients with renal insufficiency and renal failure. , 1990, The American journal of gastroenterology.

[32]  E. Balthazar CT diagnosis and staging of acute pancreatitis. , 1989, Radiologic clinics of North America.

[33]  N. Vaziri,et al.  Pancreatic enzymes in patients with end-stage renal disease maintained on hemodialysis. , 1988, The American journal of gastroenterology.

[34]  H. Corwin,et al.  Pancreatic enzymes in chronic renal failure. , 1987, Archives of internal medicine.

[35]  R. Miller,et al.  Pancreatic pathology in chronic dialysis patients--an autopsy study of 78 cases. , 1987, Nephron.

[36]  D. Bruns,et al.  Serum amylases in chronic and end-stage renal failure: effects of mode of therapy, race, diabetes and peritonitis. , 1987, American journal of nephrology.

[37]  M. Robards,et al.  Acute pancreatitis in patients with end-stage renal disease without transplantation. , 1986, Archives of internal medicine.

[38]  N. Wolfman,et al.  Pancreatitis: an important cause of abdominal symptoms in patients on peritoneal dialysis. , 1986, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[39]  D. B. Ar,et al.  Mortality in acute pancreatitis. , 1984 .

[40]  L. Miller,et al.  Pancreatic exocrine function in severe human chronic renal failure. , 1982, Gut.

[41]  L. Miller,et al.  Gastrointestinal hormone profile in renal insufficiency. , 1979, Mayo Clinic proceedings.

[42]  M. Levitt,et al.  Serum isoamylase measurements in pancreatitis complicating chronic renal failure. , 1979, The Journal of laboratory and clinical medicine.

[43]  M. Avram High prevalence of pancreatic disease in chronic renal failure. , 1977, Nephron.

[44]  A. H. Baggenstoss,et al.  The pancreas in uremia; a histopathologic study. , 1948, The American journal of pathology.