Nanotechnology and Regenerative Medicine Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice

Citation: Yungher BJ, Ribeiro M, Park KK. Regenerative responses and axon pathfinding of retinal ganglion cells in chronically injured mice. Invest Ophthalmol Vis Sci. 2017;58:1743–1750. DOI:10.1167/iovs.16-19873 PURPOSE. Enhanced regeneration of retinal ganglion cell (RGC) axons can be achieved by modification of numerous neuronal-intrinsic factors. However, axon growth initiation and the pathfinding behavior of these axons after traumatic injury remain poorly understood outside of acute injury paradigms, despite the clinical relevance of more chronic settings. We therefore examined RGC axon regeneration following therapeutic delivery that is postponed until 2 months after optic nerve crush injury.

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