Preface Further Reading Biography Introduction to Part 1 Matjaz Zorko From Building Block to 3-D Structure Amino Acids Matjaz Zorko Noncovalent Interactions Matjaz Zorko Structural Organization of Proteins Matjaz Zorko Protein Biosynthesis and Posttranslational Modifications The Biosynthesis of Proteins Matjaz Zorko Posttranslational Modifications Matjaz Zorko Folding of Proteins Protein Folding Matjaz Zorko Intracellular Sorting of Proteins Gunnar von Heijne Protein Degradation Protein Turnover Matjaz Zorko Introduction to Part II Astrid Graslund Purification and Characterization of Proteins Matjaz Zorko Crystallography and X-Ray Diffraction Astrid Graslund Optical Spectroscopy Astrid Graslund Nuclear Magnetic Resonance (NMR) Astrid Graslund Methods to Follow Protein Folding Astrid Graslund Mass Spectrometry Astrid Graslund Chemical Synthesis of Peptides and Proteins Ulo Langel Introduction to Part III Tiit Land Protein Engineering and Gene Silencing Ulo Langel Protein-Ligand Interactions Ulo Langel Sequence Analysis and Function Prediction Tiit Land Protein Structure Prediction Tiit Land Proteomics Sherry Niessen and Benjamin F. Cravatt Introduction to Part IV Ulo Langel Enzymes Matjaz Zorko Nucleic Acid-Binding Proteins Ulo Langel Cell Surface Receptors and Signaling Ulo Langel Membrane Proteins Gunnar von Heijne Antibodies Ulo Langel Fibrous Proteins Ulo Langel Selected Classes of Bioactive Peptides Ulo Langel Introduction to Part V Ulo Langel and Astrid Graslund Misfolding-Based Diseases Astrid Graslund Miscleavage-Based Diseases Astrid Graslund Missequence-Based Diseases Astrid Graslund Peptides and Proteins as Drugs Ulo Langel