Targeting novel signaling pathways for resistant acute myeloid leukemia.
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L. Platanias | S. Grant | K. Sakamoto | E. Eklund | F. Giles | N. Hijiya | J. Crispino | Diana Saleiro
[1] J. Karp,et al. New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine , 2014, Clinical Cancer Research.
[2] Guoan Zhang,et al. γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression , 2014, Cell.
[3] E. Attar,et al. New insights in AML biology from genomic analysis. , 2014, Seminars in hematology.
[4] Ho-June Lee,et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. , 2014, Cancer cell.
[5] Jiwang Zhang,et al. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML , 2014, The Journal of experimental medicine.
[6] M. Konopleva,et al. Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells , 2014, Molecular Cancer Therapeutics.
[7] A. Letai,et al. Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia. , 2014, Cancer discovery.
[8] J. T. Caldwell,et al. Acute Myeloid Leukemia Cells Harboring MLL Fusion Genes or with the Acute Promyelocytic Leukemia Phenotype Are Sensitive to the Bcl-2-selective Inhibitor ABT-199 , 2014, Leukemia.
[9] Lincoln D. Stein,et al. Identification of pre-leukemic hematopoietic stem cells in acute leukemia , 2014, Nature.
[10] A. Jegga,et al. MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 , 2014, Oncogene.
[11] S. Mi,et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia , 2014, Nature Genetics.
[12] I. Weissman,et al. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission , 2014, Proceedings of the National Academy of Sciences.
[13] G. Superti-Furga,et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. , 2013, The New England journal of medicine.
[14] Yamei Chen,et al. STAT inhibitors for cancer therapy , 2013, Journal of Hematology & Oncology.
[15] J. Dipersio,et al. Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I , 2013, Haematologica.
[16] T. Naoe,et al. A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases , 2013, Blood Cancer Journal.
[17] D. Felsher,et al. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. , 2013, Blood.
[18] K. Hofmann,et al. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes , 2013, The EMBO journal.
[19] L. Platanias,et al. The evolution of the TOR pathway and its role in cancer , 2013, Oncogene.
[20] C. Proud,et al. Rapamycin enhances eIF4E phosphorylation by activating MAP kinase‐interacting kinase 2a (Mnk2a) , 2013, FEBS letters.
[21] Ming Yan,et al. JAK inhibitors suppress t(8;21) fusion protein-induced leukemia , 2013, Leukemia.
[22] S. Armstrong,et al. Recent progress toward epigenetic therapies: the example of mixed lineage leukemia. , 2013, Blood.
[23] L. Platanias,et al. Acute myeloid leukemia: potential for new therapeutic approaches targeting mRNA translation pathways. , 2013, International journal of hematologic oncology.
[24] O. Williams,et al. In focus: MLL-rearranged leukemia , 2013, Leukemia.
[25] K. Döhner,et al. Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia , 2013, Molecular Cancer.
[26] P. Iversen,et al. Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. , 2013, Blood.
[27] G. Basso,et al. MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation , 2013, Haematologica.
[28] S. Armstrong,et al. Cell of origin determines clinically relevant subtypes of MLL-rearranged AML , 2013, Leukemia.
[29] S. Grant,et al. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. , 2013, Cancer research.
[30] J. Rowe,et al. The myth of the second remission of acute leukemia in the adult. , 2013, Blood.
[31] T. Mak,et al. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system , 2012, Nature Immunology.
[32] Menggang Yu,et al. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo , 2012, Leukemia.
[33] A. Letai,et al. Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML , 2012, Cell.
[34] Stephen L. Abrams,et al. Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response , 2012, Oncotarget.
[35] Joshua F. McMichael,et al. The Origin and Evolution of Mutations in Acute Myeloid Leukemia , 2012, Cell.
[36] K. Sakamoto,et al. Sox4 cooperates with CREB in myeloid transformation. , 2012, Blood.
[37] J. Tamburini,et al. The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia , 2012, Leukemia.
[38] Z. Estrov,et al. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia. , 2012, Blood.
[39] P. van Kerkhof,et al. Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport , 2012, Biology Open.
[40] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[41] A. Tefferi. JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths. , 2012, Blood.
[42] T. Gilmer,et al. Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations , 2012, Molecular Cancer Therapeutics.
[43] Joshua F. McMichael,et al. Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing , 2011, Nature.
[44] M. Carroll,et al. Intrinsic Resistance to JAK2 Inhibition in Myelofibrosis , 2011, Clinical Cancer Research.
[45] B. Bernstein,et al. Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy , 2011, Nature.
[46] R. Pieters,et al. Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia , 2011, Haematologica.
[47] M. J. Ruiz,et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. , 2011, Blood.
[48] A. Redig,et al. Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors , 2011, Clinical Cancer Research.
[49] K. Baggerly,et al. Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. , 2010, Blood.
[50] M. Yap,et al. FGF‐2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3‐K/GSK3β signaling , 2010, Journal of cellular physiology.
[51] L. Platanias,et al. Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses , 2010, Molecular Pharmacology.
[52] J. Tamburini,et al. Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia , 2010, Clinical Cancer Research.
[53] Z. Estrov,et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. , 2010, The New England journal of medicine.
[54] K. Sakamoto,et al. Targeting CREB for cancer therapy: friend or foe. , 2010, Current cancer drug targets.
[55] J. McCubrey,et al. The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients , 2010, Oncotarget.
[56] Su-Jae Lee,et al. Triad 1 induces apoptosis by p53 activation , 2010, FEBS letters.
[57] C. Geest,et al. MAPK signaling pathways in the regulation of hematopoiesis , 2009, Journal of leukocyte biology.
[58] P. Jansen,et al. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains , 2009, Leukemia.
[59] Giuseppe Basso,et al. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. , 2009, Cancer research.
[60] Huanming Yang,et al. Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. , 2009, Cancer research.
[61] F. Luciano,et al. Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia. , 2008, Current cancer drug targets.
[62] S. Nelson,et al. CREB regulates Meis1 expression in normal and malignant hematopoietic cells , 2008, Leukemia.
[63] K. Sakamoto,et al. CREB is a critical regulator of normal hematopoiesis and leukemogenesis. , 2008, Blood.
[64] M. Odero,et al. JAK2-V617F activating mutation in acute myeloid leukemia: prognostic impact and association with other molecular markers , 2007, Leukemia.
[65] D. Gary Gilliland,et al. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders , 2007, Nature Reviews Cancer.
[66] K. Sakamoto,et al. Potential role of CREB as a prognostic marker in acute myeloid leukemia. , 2007, Future oncology.
[67] Ceri M. Wiggins,et al. ERK1/2‐dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl‐1 and Bcl‐xL , 2007, The EMBO journal.
[68] Hao Wang,et al. Activation of SHP2 Protein-tyrosine Phosphatase Increases HoxA10-induced Repression of the Genes Encoding gp91PHOX and p67PHOX* , 2007, Journal of Biological Chemistry.
[69] J. Esteve,et al. Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. , 2006, Cancer research.
[70] D. Steensma,et al. JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained , 2006, Leukemia.
[71] D. Green,et al. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. , 2006, Molecular cell.
[72] J. Jansen,et al. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. , 2005, Blood.
[73] K. Sakamoto,et al. Role of cyclic AMP response element binding protein in human leukemias , 2005, Cancer.
[74] N. Rao,et al. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. , 2005, Cancer cell.
[75] Yufeng Lu,et al. HOXA9 Activates Transcription of the Gene Encoding gp91Phox during Myeloid Differentiation* , 2005, Journal of Biological Chemistry.
[76] K. Sakamoto,et al. Transcriptional Regulators and Myelopoiesis: The Role of Serum Response Factor and CREB as Targets of Cytokine Signaling , 2003, Stem cells.
[77] S. Bhatia,et al. Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia. , 2002, Blood.
[78] A. Baron,et al. Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia , 2002, Leukemia.
[79] S. Karlsson,et al. Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10. , 2001, Blood.
[80] W. Berdel,et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. , 2000, Blood.
[81] E. Eklund,et al. Tyrosine Phosphorylation of HoxA10 Decreases DNA Binding and Transcriptional Repression during Interferon γ-induced Differentiation of Myeloid Leukemia Cell Lines* , 2000, The Journal of Biological Chemistry.
[82] B. Johansson,et al. Deletion of chromosome arm 3p in hematologic malignancies , 1997, Leukemia.
[83] U. Thorsteinsdóttir,et al. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia , 1997, Molecular and cellular biology.
[84] E. Estey,et al. CME Information: Acute myeloid leukemia: 2014 update on risk-stratification and management , 2014 .
[85] N. Hayward,et al. Molecular Pathways Molecular Pathways : Mitogen-Activated Protein Kinase Pathway Mutations and Drug Resistance , 2013 .
[86] Kerby Shedden,et al. Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia. , 2013, Blood.
[87] Y. Matsubara,et al. Ras/MAPK syndromes and childhood hemato-oncological diseases , 2012, International Journal of Hematology.
[88] M. Konopleva,et al. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex , 2012, Leukemia.
[89] S. Knauer,et al. Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1. , 2012, The international journal of biochemistry & cell biology.
[90] K. Sakamoto,et al. CREB and leukemogenesis. , 2011, Critical reviews in oncogenesis.
[91] A. Shaywitz,et al. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. , 1999, Annual review of biochemistry.
[92] D. Hossfeld,et al. 3p21 is a recurrent treatment-related breakpoint in myelodysplastic syndrome and acute myeloid leukemia. , 1996, Cytogenetics and cell genetics.