APRIL levels are associated with disease activity in human chronic graft-versus-host disease

After allogeneic hematopoietic stem cell transplantation (AHSCT), acute GVHD is almost entirely mediated by donor T cells whereas chronic graft- versus -host disease (cGVHD) also involves donor B cells.[1][1] A breakdown in peripheral B cell homeostasis in cGVHD is in part due to high levels of B

[1]  M. Robin,et al.  CD24(hi)CD27⁺ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. , 2015, Blood.

[2]  H. Greinix,et al.  National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease , 2015 .

[3]  Daniel Wolff,et al.  National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. , 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[4]  J. Ritz,et al.  B cells in chronic graft-versus-host disease. , 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[5]  P. Schneider,et al.  The BAFF/APRIL system in SLE pathogenesis , 2014, Nature Reviews Rheumatology.

[6]  J. Ritz,et al.  Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease. , 2014, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[7]  K. Fairfax,et al.  The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity , 2013, Cytokine & Growth Factor Reviews.

[8]  Yu Qian,et al.  Advances in Human B Cell Phenotypic Profiling , 2012, Front. Immun..

[9]  M. Rybojad,et al.  Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF Levels , 2012, PloS one.

[10]  T. Samulski,et al.  Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development. , 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[11]  P. Schneider,et al.  Cracking the BAFF code , 2009, Nature Reviews Immunology.

[12]  J. Ritz,et al.  Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease. , 2009, Blood.

[13]  D. Jelinek,et al.  Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation1 , 2007, The Journal of Immunology.

[14]  J. Ritz,et al.  High Levels of B-Cell Activating Factor in Patients with Active Chronic Graft-Versus-Host Disease , 2007, Clinical Cancer Research.

[15]  R. Carsetti,et al.  Peripheral development of B cells in mouse and man , 2004, Immunological reviews.

[16]  Don Foster,et al.  TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease , 2000, Nature.