Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.
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A. Harris | A. Schulze | F. Karpe | K. Bensaad | B. Peck | Ji-Liang Li | Jennifer M. Collins | M. Wakelam | S. Wigfield | F. Buffa | C. Lewis | Qifeng Zhang | S. Lord | E. Favaro | Katherine E. Pinnick
[1] A. Mancuso,et al. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. , 2013, Genes & development.
[2] E. White,et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids , 2013, Proceedings of the National Academy of Sciences.
[3] Adrian L Harris,et al. Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells. , 2012, Cell metabolism.
[4] S. Siniossoglou,et al. Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression , 2012, Journal of Cell Science.
[5] J. Norman,et al. Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration , 2012, The Journal of cell biology.
[6] Jia Yu,et al. Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. , 2012, The Biochemical journal.
[7] A. Giordano,et al. Hypoxia induces peroxisome proliferator‐activated receptor α (PPARα) and lipid metabolism peroxisomal enzymes in human glioblastoma cells , 2011, Journal of cellular biochemistry.
[8] Christian M. Metallo,et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.
[9] A. Harris,et al. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. , 2011, Cancer research.
[10] M. Neville,et al. De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation[S] , 2011, Journal of Lipid Research.
[11] H. Abramson. The lipogenesis pathway as a cancer target. , 2011, Journal of medicinal chemistry.
[12] C. Dang,et al. Otto Warburg's contributions to current concepts of cancer metabolism , 2011, Nature Reviews Cancer.
[13] Min Wu,et al. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. , 2011, Biochimica et biophysica acta.
[14] A. Harris,et al. The angiogenic process as a therapeutic target in cancer. , 2011, Biochemical pharmacology.
[15] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[16] D. Petersen,et al. The human fatty acid-binding protein family: Evolutionary divergences and functions , 2011, Human Genomics.
[17] Karen H. Vousden,et al. Metabolic regulation by p53 , 2011, Journal of Molecular Medicine.
[18] T. Mak,et al. Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.
[19] B. Eisenberg,et al. Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation , 2011, Molecular Cancer Therapeutics.
[20] N. Prabhakar,et al. Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS , 2010, Respiratory Physiology & Neurobiology.
[21] A. Levine,et al. The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes , 2010, Science.
[22] C. Hellerbrand,et al. Hypoxia‐inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia‐inducible factor‐1 , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[23] R. Ahima,et al. Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. , 2010, American journal of physiology. Endocrinology and metabolism.
[24] G. Semenza,et al. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. , 2010, Cardiovascular research.
[25] A. Harris,et al. Mechanisms of resistance to antiangiogenesis therapy. , 2010, European journal of cancer.
[26] M. Loda,et al. Fatty acid synthase as a potential therapeutic target in cancer. , 2010, Future oncology.
[27] J. Viola,et al. Lipid droplets in inflammation and cancer. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.
[28] M. Neville,et al. Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet β‐cells to fatty acids , 2010, Journal of cellular biochemistry.
[29] G. Semenza. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics , 2010, Oncogene.
[30] D. Nomura,et al. Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis , 2010, Cell.
[31] K. Kaluarachchi,et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. , 2010, The Journal of clinical investigation.
[32] F. Shibasaki,et al. Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors , 2009, Experimental & Molecular Medicine.
[33] Robert V Farese,et al. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T , 2009, Cell.
[34] J. Peychl,et al. Live Cell Multicolor Imaging of Lipid Droplets with a New Dye, LD540 , 2009, Traffic.
[35] Kevin M. Ryan,et al. p53 and metabolism , 2009, Nature Reviews Cancer.
[36] Ziwei Gu,et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. , 2009, Chemistry & biology.
[37] L. Cantley,et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.
[38] A. Walch,et al. Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion , 2009, Proceedings of the National Academy of Sciences.
[39] S. Fox,et al. The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy , 2009, British Journal of Cancer.
[40] V. A. Flørenes,et al. The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells , 2008, BMC Cancer.
[41] L. Wojtczak,et al. Fatty acids as modulators of the cellular production of reactive oxygen species. , 2008, Free radical biology & medicine.
[42] C. Michiels,et al. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours , 2008, The FEBS journal.
[43] A. Ivascu,et al. Diversity of cell-mediated adhesions in breast cancer spheroids. , 2007, International journal of oncology.
[44] J. Menéndez,et al. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.
[45] C. Thompson,et al. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. , 2007, Cancer cell.
[46] Y. Marie,et al. FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status , 2007, Journal of Neuro-Oncology.
[47] J. Ericsson,et al. SREBP in signal transduction: cholesterol metabolism and beyond. , 2007, Current opinion in cell biology.
[48] A. Ivascu,et al. Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity Analysis , 2006, Journal of biomolecular screening.
[49] P. Schumacker,et al. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia , 2006, Experimental physiology.
[50] J. Swinnen,et al. Increased lipogenesis in cancer cells: new players, novel targets , 2006, Current opinion in clinical nutrition and metabolic care.
[51] P. Schumacker,et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. , 2005, Cell metabolism.
[52] M. Décorps,et al. Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection , 2003, British Journal of Cancer.
[53] Robert V Farese,et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[54] O. Hankinson,et al. Mitogen‐inducible gene 6 (MIG‐6), adipophilin and tuftelin are inducible by hypoxia , 2002, FEBS letters.
[55] R. Aebersold,et al. Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER , 2002, Cell.
[56] G. Serrero,et al. Adipose Differentiation Related Protein (ADRP) Expressed in Transfected COS-7 Cells Selectively Stimulates Long Chain Fatty Acid Uptake* , 1999, The Journal of Biological Chemistry.
[57] J. Mcwhir,et al. Requirement for the heart‐type fatty acid binding protein in cardiac fatty acid utilization , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[58] Andrej Sali,et al. Ligand Specificity of Brain Lipid-binding Protein* , 1996, The Journal of Biological Chemistry.
[59] D. Schoeller,et al. Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. , 1994, The American journal of physiology.
[60] H. Schulz,et al. NADPH-dependent beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[61] K. Watabe,et al. Acetyl-CoA carboxylase-a as a novel target for cancer therapy. , 2010, Frontiers in bioscience.
[62] J. Griffiths,et al. The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. , 2010, Advances in enzyme regulation.
[63] M. Simon,et al. Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. , 2006, Current topics in developmental biology.