Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats

Background/Aims: Oxidative stress is presumed to play an important role in hepatic fibrogenesis. Diets high in polyunsaturated fatty acids (PUFA) enhance fibrosis and have been associated with increased oxidative damage in some models of liver injury. The aim of this study was to determine the effects of dietary fat of varying PUFA content on iron‐induced oxidative stress and fibrosis.

[1]  B. Bacon,et al.  Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells , 2002, Journal of gastroenterology and hepatology.

[2]  D. Purdie,et al.  Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. , 2002, Gastroenterology.

[3]  R. Leboeuf,et al.  Iron overload diminishes atherosclerosis in apoE-deficient mice. , 2001, The Journal of clinical investigation.

[4]  P. Adams.  Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis , 2001 .

[5]  K. Batts,et al.  Hemochromatosis: Liver biopsy in hemochromatosis , 2000 .

[6]  L. Ridnour,et al.  Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives. , 1999, Methods in enzymology.

[7]  A. Nanji,et al.  Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil , 1998, Hepatology.

[8]  H. Frierson,et al.  Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. , 1998, Free radical biology & medicine.

[9]  K. E. Brown,et al.  Oxidized heme proteins in an animal model of hemochromatosis. , 1998, Free radical biology & medicine.

[10]  B. Neuschwander‐Tetri,et al.  Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis , 1997, Hepatology.

[11]  S. Tahan,et al.  Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat , 1997, Hepatology.

[12]  C. Lynch,et al.  Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components. , 1997, The American journal of physiology.

[13]  K. S. Lee,et al.  Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. , 1995, The Journal of clinical investigation.

[14]  A. Nanji,et al.  Dietary saturated fatty acids: a novel treatment for alcoholic liver disease. , 1995, Gastroenterology.

[15]  G. Ansari,et al.  Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme. , 1995, Toxicology and applied pharmacology.

[16]  E. Shacter,et al.  Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. , 1994, Free radical biology & medicine.

[17]  A. Nanji,et al.  Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. , 1994, Alcoholism, clinical and experimental research.

[18]  J. Maher,et al.  Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. , 1994, Alcohol and alcoholism.

[19]  C. Trautwein,et al.  Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis? , 1994, Hepatology.

[20]  T. Kaduce,et al.  Formation and release of a peroxisome-dependent arachidonic acid metabolite by human skin fibroblasts. , 1994, The Journal of biological chemistry.

[21]  L. Powell,et al.  Effect of chronic iron overload on procollagen gene expression , 1993, Hepatology.

[22]  A. Gentilini,et al.  Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. , 1993, Biochemical and biophysical research communications.

[23]  M. Friedman,et al.  Dietary fat exacerbates liver disease in bile duct-ligated rats. , 1993, The Journal of nutrition.

[24]  S. Friedman.  The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies , 1993 .

[25]  S. Friedman,et al.  Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. , 1992, Journal of submicroscopic cytology and pathology.

[26]  S. Kubow,et al.  Routes of formation and toxic consequences of lipid oxidation products in foods. , 1992, Free radical biology & medicine.

[27]  S. Phinney,et al.  Ethanol‐induced changes in hepatic free radical defense mechanisms and fatty‐acid composition in the miniature pig , 1991, Hepatology.

[28]  J. Kinsella.  Dietary n-3 polyunsaturated fatty acids of fish oils, autoxidation ex vivo and peroxidation in vivo: implications. , 1991, Advances in experimental medicine and biology.

[29]  T. Ogino,et al.  Stimulation of glutathione synthesis in iron-loaded mice. , 1989, Biochimica et biophysica acta.

[30]  A. Nanji,et al.  Beef fat prevents alcoholic liver disease in the rat. , 1989, Alcoholism, clinical and experimental research.

[31]  B. Bacon,et al.  Pathology of dietary carbonyl iron overload in rats. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[32]  R. Ward,et al.  Ultrastructural observations in the carbonyl iron-fed rat, an animal model for hemochromatosis , 1987, Virchows Archiv. B, Cell pathology including molecular pathology.

[33]  H. Tsukamoto,et al.  Ethanol‐induced liver fibrosis in rats fed high fat diet , 1986, Hepatology.

[34]  L. Weintraub,et al.  Pathogenesis of hepatic fibrosis in experimental iron overload , 1985, British journal of haematology.

[35]  V. Valli,et al.  Oral toxicity of malonaldehyde: a 90-day study on mice. , 1983, Journal of toxicology and environmental health.

[36]  J. Torrance.  Tissue iron stores , 1980 .

[37]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[38]  H. Goldblatt,et al.  FURTHER OBSERVATIONS ON THE PRODUCTION AND PREVENTION OF DIETARY HEPATIC INJURY IN RATS , 1949, The Journal of experimental medicine.