Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats

[1]  K. Sasao,et al.  Early Administration of Sivelestat, the Neutrophil Elastase Inhibitor, in Adults for Acute Lung Injury Following Gastric Aspiration , 2011, Shock.

[2]  O. Soehnlein,et al.  Contribution of Neutrophils to Acute Lung Injury , 2011, Molecular medicine.

[3]  M. Saito,et al.  Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia–reperfusion injury in rats , 2011, BJU international.

[4]  K. Kubo,et al.  Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats. , 2010, European journal of pharmacology.

[5]  P. Ward,et al.  Oxidative stress: acute and progressive lung injury , 2010, Annals of the New York Academy of Sciences.

[6]  H. Koga,et al.  The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. , 2010, The Journal of trauma.

[7]  X. Ni,et al.  Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. , 2010, European journal of pharmacology.

[8]  N. Ohkohchi,et al.  Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion. , 2009, Journal of Surgical Research.

[9]  P. Leung,et al.  Role of oxidative stress in pancreatic inflammation. , 2009, Antioxidants & redox signaling.

[10]  M. Bando,et al.  Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice , 2008, European Respiratory Journal.

[11]  H. Iwasaka,et al.  A Neutrophil Elastase Inhibitor, Sivelestat, Reduces Lung Injury Following Endotoxin-Induced Shock in Rats by Inhibiting HMGB1 , 2008, Inflammation.

[12]  P. Hassoun,et al.  Xanthine oxidoreductase in respiratory and cardiovascular disorders. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[13]  P. Ward,et al.  Role of oxidants in lung injury during sepsis. , 2007, Antioxidants & redox signaling.

[14]  Y. Nishimura,et al.  Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice. , 2007, European journal of pharmacology.

[15]  Toru Takahashi,et al.  A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. , 2007, International journal of molecular medicine.

[16]  Y. Namiki,et al.  Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. , 2006, CNS drug reviews.

[17]  Diane P. Martin,et al.  Incidence and outcomes of acute lung injury. , 2005, The New England journal of medicine.

[18]  T. Petty,et al.  Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. The Lancet, Saturday 12 August 1967. , 2005, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[19]  R. Hubmayr,et al.  New insights into the pathology of acute respiratory failure , 2005, Current opinion in critical care.

[20]  Koji Ito,et al.  Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. , 2005, Free radical biology & medicine.

[21]  G. Bernard,et al.  Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study , 2004, Critical care medicine.

[22]  Edward Abraham,et al.  Neutrophils and acute lung injury , 2003, Critical care medicine.

[23]  D. DeLong,et al.  Effect of a Novel Free Radical Scavenger, Edaravone (MCI-186), on Acute Brain Infarction , 2003, Cerebrovascular Diseases.

[24]  E. Otomo.  Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. , 2003, Cerebrovascular diseases.

[25]  K. Kawabata,et al.  The role of neutrophil elastase in acute lung injury. , 2002, European journal of pharmacology.

[26]  H. Makita,et al.  Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[27]  J. Repine,et al.  Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics , 2002, Critical care medicine.

[28]  R. Reiter,et al.  Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin , 2002, Mechanisms of Ageing and Development.

[29]  S. Nakao,et al.  Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. , 2001, European journal of pharmacology.

[30]  G. Downey,et al.  Neutrophil activation and acute lung injury , 2001, Current opinion in critical care.

[31]  K. Kubo,et al.  Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat. , 2000, European journal of pharmacology.

[32]  S. Nakao,et al.  Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. , 2000, American journal of respiratory and critical care medicine.

[33]  L. Joosten,et al.  Neutralization of IL-18 Reduces Neutrophil Tissue Accumulation and Protects Mice Against Lethal Escherichia coli and Salmonella typhimurium Endotoxemia1 , 2000, The Journal of Immunology.

[34]  W. MacNee,et al.  Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[35]  P. Hassoun,et al.  Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury. , 1998, American journal of respiratory and critical care medicine.

[36]  S. Miyake,et al.  Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs. , 1998, American journal of respiratory and critical care medicine.

[37]  P. Hassoun,et al.  Regulation of intracellular xanthine oxidase by endothelial-derived nitric oxide. , 1996, The American journal of physiology.

[38]  R. Faggioni,et al.  Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema. , 1994, The Journal of laboratory and clinical medicine.

[39]  M. Denis,et al.  Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. , 1993, American journal of respiratory cell and molecular biology.

[40]  P. Ward,et al.  Mechanism of neutrophil-induced xanthine dehydrogenase to xanthine oxidase conversion in endothelial cells: evidence of a role for elastase. , 1992, American journal of respiratory cell and molecular biology.

[41]  C. White,et al.  O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs. , 1986, Journal of applied physiology.

[42]  A. Fein,et al.  Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome. , 1981, The New England journal of medicine.

[43]  T L Petty,et al.  Acute respiratory distress in adults. , 1967, Lancet.