Optimism and the brain: trait optimism mediates the protective role of the orbitofrontal cortex gray matter volume against anxiety.

Converging evidence identifies trait optimism and the orbitofrontal cortex (OFC) as personality and brain factors influencing anxiety, but the nature of their relationships remains unclear. Here, the mechanisms underlying the protective role of trait optimism and of increased OFC volume against symptoms of anxiety were investigated in 61 healthy subjects, who completed measures of trait optimism and anxiety, and underwent structural scanning using magnetic resonance imaging. First, the OFC gray matter volume (GMV) was associated with increased optimism, which in turn was associated with reduced anxiety. Second, trait optimism mediated the relation between the left OFC volume and anxiety, thus demonstrating that increased GMV in this brain region protects against symptoms of anxiety through increased optimism. These results provide novel evidence about the brain-personality mechanisms protecting against anxiety symptoms in healthy functioning, and identify potential targets for preventive and therapeutic interventions aimed at reducing susceptibility and increasing resilience against emotional disturbances.

[1]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[2]  Anna S. Engels,et al.  Trait motivation moderates neural activation associated with goal pursuit , 2012, Cognitive, Affective, & Behavioral Neuroscience.

[3]  Karolina M. Lempert,et al.  Emotion and decision making: multiple modulatory neural circuits. , 2014, Annual review of neuroscience.

[4]  D. Zald,et al.  Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making , 2012, The Journal of Neuroscience.

[5]  Gesamtverband Deutscher Nervenärzte.  European archives of psychiatry and clinical neuroscience , 1990 .

[6]  Kristopher J Preacher,et al.  Effect size measures for mediation models: quantitative strategies for communicating indirect effects. , 2011, Psychological methods.

[7]  A. Etkin,et al.  Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. , 2007, The American journal of psychiatry.

[8]  I. Gotlib,et al.  Emotion Regulation in Depression and Anxiety: Examining Diagnostic Specificity and Stability of Strategy Use , 2013, Cognitive Therapy and Research.

[9]  M. Peters,et al.  Become more optimistic by imagining a best possible self: effects of a two week intervention. , 2011, Journal of behavior therapy and experimental psychiatry.

[10]  J. Gross,et al.  Anterior cingulate cortex volume and emotion regulation: Is bigger better? , 2011, Biological Psychology.

[11]  Antonio Rangel,et al.  Neural computations associated with goal-directed choice , 2010, Current Opinion in Neurobiology.

[12]  L. Jäncke,et al.  Evidence of frontotemporal structural hypoconnectivity in social anxiety disorder: A quantitative fiber tractography study , 2013, Human brain mapping.

[13]  G. A. Miller,et al.  Contrasting patterns of brain activity in anxious apprehension and anxious arousal. , 1999, Psychophysiology.

[14]  C. Murray,et al.  The state of US health, : burden of diseases, injuries, and risk factors. , 2013 .

[15]  Lao Juan,et al.  Development and Validation of a Scale for Measuring Instructors' Attitudes toward Concept-Based or Reform-Oriented Teaching of Introductory Statistics in the Health and Behavioral Sciences , 2010, 1007.3219.

[16]  J. Gray,et al.  Testing Predictions From Personality Neuroscience , 2010, Psychological science.

[17]  Bryan Gibson,et al.  Optimism, Pessimism, and Gambling: The Downside of Optimism , 2004, Personality & social psychology bulletin.

[18]  G. Andersson.  The benefits of optimism: A meta-analytic review of the life orientation test , 1996 .

[19]  C. Spielberger,et al.  Manual for the State-Trait Anxiety Inventory , 1970 .

[20]  L. Bullock,et al.  Optimism and other psychosocial influences on antenatal depression: a systematic review. , 2012, Nursing & health sciences.

[21]  D. Grupe,et al.  Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective , 2013, Nature Reviews Neuroscience.

[22]  M. Kringelbach.  The human orbitofrontal cortex: linking reward to hedonic experience , 2005, Nature Reviews Neuroscience.

[23]  Suzanne C. Segerstrom,et al.  Dispositional Optimism and Coping: A Meta-Analytic Review , 2006, Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc.

[24]  Zachary P. Infantolino,et al.  Issues in localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology , 2013, Front. Integr. Neurosci..

[25]  David Hecht.  The Neural Basis of Optimism and Pessimism , 2013, Experimental neurobiology.

[26]  E. Rolls,et al.  Value, Pleasure and Choice in the Ventral Prefrontal Cortex , 2022 .

[27]  Edgar Erdfelder,et al.  G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences , 2007, Behavior research methods.

[28]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[29]  Michael W. Bridges,et al.  Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): a reevaluation of the Life Orientation Test. , 1994, Journal of personality and social psychology.

[30]  Carol R. Glass,et al.  Worry, Optimism, and Expectations as Predictors of Anxiety and Performance in the First Year of Law School , 2006, Cognitive Therapy and Research.

[31]  Myrna M. Weissman,et al.  Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies , 2013, Biological Psychiatry.

[32]  D. Watson,et al.  Development and validation of brief measures of positive and negative affect: the PANAS scales. , 1988, Journal of personality and social psychology.

[33]  Bruce Fischl,et al.  FreeSurfer , 2012, NeuroImage.

[34]  Matthew S. Fritz,et al.  PSYCHOLOGICAL SCIENCE Research Article Required Sample Size to Detect the Mediated Effect , 2022 .

[35]  Philip A. Gable,et al.  Neural Activity Underlying the Effect of Approach-Motivated Positive Affect on Narrowed Attention , 2009, Psychological science.

[36]  M. Delgado,et al.  Acute Stress Influences Neural Circuits of Reward Processing , 2012, Front. Neurosci..

[37]  Foreman,et al.  The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. , 2013, JAMA.

[38]  Andrea Parolin Jackowski,et al.  The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings. , 2012, Revista brasileira de psiquiatria.

[39]  Florin Dolcos,et al.  Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study , 2004, NeuroImage.

[40]  Olga V. Demler,et al.  Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[41]  J. Dreher,et al.  Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies , 2013, Neuroscience & Biobehavioral Reviews.

[42]  R. Gonzalez.  Applied Multivariate Statistics for the Social Sciences , 2003 .

[43]  S. Southwick,et al.  The Science of Resilience: Implications for the Prevention and Treatment of Depression , 2012, Science.

[44]  Randy L. Buckner,et al.  Individual Differences in Amygdala-Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk , 2012, The Journal of Neuroscience.

[45]  Joseph W. Kable,et al.  The valuation system: A coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value , 2013, NeuroImage.

[46]  References , 1971 .

[47]  S. Khushu,et al.  Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study , 2013, Behavioural Brain Research.

[48]  R T Constable,et al.  Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity , 2013, Translational Psychiatry.

[49]  K. Berridge,et al.  Towards a functional neuroanatomy of pleasure and happiness , 2009, Trends in Cognitive Sciences.

[50]  K. Merikangas,et al.  Lifetime prevalence and age of onset of psychiatric disorders: recall 4 years later. , 1988, Journal of psychiatric research.

[51]  R. Davidson,et al.  Social influences on neuroplasticity: stress and interventions to promote well-being , 2012, Nature Neuroscience.

[52]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[53]  P. Glimcher,et al.  Neuroanatomy Predicts Individual Risk Attitudes , 2014, The Journal of Neuroscience.

[54]  Israel Liberzon,et al.  Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder , 2009, Biological Psychiatry.

[55]  Kenneth M. Prkachin,et al.  Optimism and Unrealistic Optimism have an Interacting Impact on Health-Promoting Behavior and Knowledge Changes , 1997 .

[56]  René Reich-Graefe.  Keep Calm and Carry On , 2014 .

[57]  S. Brooks,et al.  Applied Multivariate Statistics for the Social Sciences , 1993 .

[58]  G. Rees,et al.  The structural basis of inter-individual differences in human behaviour and cognition , 2011, Nature Reviews Neuroscience.

[59]  Jin Fan,et al.  Common and distinct networks underlying reward valence and processing stages: A meta-analysis of functional neuroimaging studies , 2011, Neuroscience & Biobehavioral Reviews.

[60]  Suzanne Wasylink,et al.  Resting state functional connectivity predicts neurofeedback response , 2014, Front. Behav. Neurosci..

[61]  Kristopher J Preacher,et al.  SPSS and SAS procedures for estimating indirect effects in simple mediation models , 2004, Behavior research methods, instruments, & computers : a journal of the Psychonomic Society, Inc.

[62]  Axel Schäfer,et al.  Symptom provocation and reduction in patients suffering from spider phobia , 2007, European Archives of Psychiatry and Clinical Neuroscience.

[63]  Rajita Sinha,et al.  Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions , 2012, Biological Psychiatry.

[64]  F. Dolcos,et al.  Reappraisal and suppression mediate the contribution of regulatory focus to anxiety in healthy adults. , 2013, Emotion.

[65]  Gregory A. Miller,et al.  Trait approach and avoidance motivation: Lateralized neural activity associated with executive function , 2011, NeuroImage.

[66]  I. Liberzon,et al.  The Neurocircuitry of Fear, Stress, and Anxiety Disorders , 2011, Neuropsychopharmacology.

[67]  K. Krishnan,et al.  Neural correlates of idiographic goal priming in depression: goal-specific dysfunctions in the orbitofrontal cortex. , 2009, Social cognitive and affective neuroscience.

[68]  D. Charney,et al.  Understanding resilience , 2013, Front. Behav. Neurosci..

[69]  C. Carver,et al.  Dispositional optimism , 2014, Trends in Cognitive Sciences.

[70]  Larry Dossey,et al.  Optimism , 1908, Explore.

[71]  Jennifer S. Beer,et al.  Three Ways in Which Midline Regions Contribute to Self-Evaluation , 2013, Front. Hum. Neurosci..

[72]  Timothy J. Strauman,et al.  Neural Correlates of Promotion and Prevention Goal Activation: An fMRI Study using an Idiographic Approach , 2007, Journal of Cognitive Neuroscience.

[73]  A. Beck,et al.  Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation , 1988 .

[74]  Julia Williams.  Keep calm and carry on. , 2010, British journal of nursing.

[75]  Geraint Rees,et al.  Selectively altering belief formation in the human brain , 2012, Proceedings of the National Academy of Sciences.

[76]  S. Segerstrom.  Optimism and Attentional Bias for Negative and Positive Stimuli , 2001 .

[77]  E. Erdfelder,et al.  Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses , 2009, Behavior research methods.

[78]  Anders M. Dale,et al.  An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest , 2006, NeuroImage.

[79]  Anna S. Engels,et al.  Specificity of regional brain activity in anxiety types during emotion processing. , 2007 .

[80]  A. Hinz,et al.  The impact of optimism on anxiety, depression and quality of life in urogenital cancer patients , 2010, Psycho-oncology.

[81]  Gregory A. Miller,et al.  Distinguishing Dimensions of Anxiety and Depression , 2001, Cognitive Therapy and Research.

[82]  M. Bateson,et al.  Anxiety: An Evolutionary Approach , 2011, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[83]  T. Insel,et al.  Wesleyan University From the SelectedWorks of Charles A . Sanislow , Ph . D . 2010 Research Domain Criteria ( RDoC ) : Toward a New Classification Framework for Research on Mental Disorders , 2018 .

[84]  R. Kawashima,et al.  Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress , 2013, Molecular Psychiatry.

[85]  Christian Montag,et al.  Imaging the structure of the human anxious brain: a review of findings from neuroscientific personality psychology , 2014 .

[86]  M. Brass,et al.  “Keep Calm and Carry On”: Structural Correlates of Expressive Suppression of Emotions , 2011, PloS one.

[87]  R. Davidson,et al.  The functional neuroanatomy of emotion and affective style , 1999, Trends in Cognitive Sciences.

[88]  Do P. M. Tromp,et al.  Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. , 2012, Archives of general psychiatry.

[89]  Jennifer A. Silvers,et al.  Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies. , 2014, Cerebral cortex.

[90]  J. Gabrieli,et al.  Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion , 2002, Journal of Cognitive Neuroscience.

[91]  H. Kappes,et al.  Positive fantasies about idealized futures sap energy , 2011 .

[92]  T. Wadden,et al.  Expectation, fantasy, and weight loss: Is the impact of positive thinking always positive? , 1991, Cognitive Therapy and Research.

[93]  Christoph W Korn,et al.  How unrealistic optimism is maintained in the face of reality , 2011, Nature Neuroscience.

[94]  Anna S. Engels,et al.  Specificity of regional brain activity in anxiety types during emotion processing , 2008, Brain and Cognition.