Measurement of therapeutic 12C beam in a water phantom using CR-39

The motivation for this study was to explore a new method to test the particle spatial distribution for a therapeutic carbon beam. CR-39 plastic nuclear track detectors were irradiated to a 276.5 MeV u−1 mono-energy carbon beam at the heavy ion facility in the Shanghai Proton and Heavy Ion Center. The spatial distribution of the primary carbon beam and secondary fragments in a water phantom were systematically analyzed both in the transverse direction (perpendicular to the projection direction of the primary beam) and at different depths in the longitudinal direction (along the projection direction of the primary beam) with measured tracks on the CR-39 detectors. Meanwhile, the theoretically spatial distribution and linear energy transfer (LET) spectra of the primary beam and secondary fragments were calculated using the Monte Carlo (MC) toolkit Geant4. The results showed that the CR-39 detectors are capable of providing high lateral resolution of carbon ion at different depths. In the range of the primary carbon beam, the beam width simulated with MC is in good agreement with that of experimental measurement. The track size registered in the CR-39 has a good correlation with the particle LET. These findings indicate that the CR-39 can be used for measuring both the particle flux and its spatial distribution of carbon ions.

[1]  L. Dewerd,et al.  LET response variability of Gafchromic TM EBT3 film from a 60 Co calibration in clinical proton beam qualities. , 2019, Medical physics.

[2]  P. Bilski,et al.  Proton induced target fragmentation studies on solid state nuclear track detectors using Carbon radiators , 2018 .

[3]  Sun Il Kwon,et al.  Towards time-of-flight PET with a semiconductor detector , 2018, Physics in medicine and biology.

[4]  C. Finck,et al.  Analytical dose modeling for preclinical proton irradiation of millimetric targets , 2018, Medical physics.

[5]  W. Zhuo,et al.  Uncertainty of an automatic system for counting alpha tracks on CR-39 , 2017 .

[6]  S. Incerti,et al.  Validation of Geant4 fragmentation for heavy ion therapy , 2017 .

[7]  M. Durante,et al.  Benchmarking Geant4 hadronic models for prompt‐γ monitoring in carbon ion therapy , 2017, Medical physics.

[8]  Bin Zhang,et al.  Monte Carlo simulation for calculation of fragments produced by 400 MeV/u carbon ion beam in water , 2017 .

[9]  N. Hasebe,et al.  A performance test of a new high-surface-quality and high-sensitivity CR-39 plastic nuclear track detector – TechnoTrak , 2016 .

[10]  R. Mohan,et al.  Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. , 2015, Medical physics.

[11]  G. Sawakuchi,et al.  Comparison of linear energy transfer scoring techniques in Monte Carlo simulations of proton beams , 2015, Physics in medicine and biology.

[12]  S. Kodaira,et al.  Note: Application of CR-39 plastic nuclear track detectors for quality assurance of mixed oxide fuel pellets. , 2015, The Review of scientific instruments.

[13]  L. Sihver,et al.  On the use of CR-39 PNTD with AFM analysis in measuring proton-induced target fragmentation particles , 2015 .

[14]  G Cuttone,et al.  A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line , 2014, Physics in medicine and biology.

[15]  U. Schneider,et al.  Measurements of the neutron dose equivalent for various radiation qualities, treatment machines and delivery techniques in radiation therapy , 2014, Physics in medicine and biology.

[16]  E. Benton,et al.  Calibration of CR-39 with atomic force microscope for the measurement of short range tracks from proton-induced target fragmentation reactions , 2013 .

[17]  V Patera,et al.  Carbon fragmentation measurements and validation of the Geant4 nuclear reaction models for hadrontherapy , 2012, Physics in medicine and biology.

[18]  L. Patrizii,et al.  Calibration of CR39 detectors with new system for Fe26+ ion beam and measurement of total charge changing cross-section in Al target , 2012 .

[19]  Xinhua Ma,et al.  Accurate measurement of the radon exhalation rate of building materials using the closed chamber method , 2012, Journal of radiological protection : official journal of the Society for Radiological Protection.

[20]  H Paganetti,et al.  Elevated LET components in clinical proton beams , 2011, Physics in medicine and biology.

[21]  A. Lechner,et al.  Validation of recent Geant4 physics models for application in carbon ion therapy , 2010 .

[22]  M. Giorgini Fragmentation cross-sections of Fe26+, Si14+ and C6+ ions of 0.3 ÷ 10 A GeV on polyethylene, CR-39 and aluminum targets , 2008, 0812.0236.

[23]  G. Giacomelli,et al.  Fragmentation cross sections of Fe^{26+}, Si^{14+} and C^{6+} ions of 0.3-10 A GeV on polyethylene, CR39 and aluminum targets , 2008, 0801.3195.

[24]  T. Kanai,et al.  Measurements of Dose-Averaged Linear Energy Transfer Distributions in Water Using CR-39 Plastic Nuclear Track Detector for Therapeutic Carbon Ion Beams , 2005 .

[25]  A. Dell'Acqua,et al.  Geant4 - A simulation toolkit , 2003 .