Treatment trial of oxiracetam in Alzheimer's disease.

Twenty-four carefully assessed patients with probable Alzheimer's disease were enrolled in a double-blind, placebo-controlled treatment study of oxiracetam, a nootropic agent reported to improve memory performance in patients with dementia. A broad battery of neuropsychological tests failed to reveal any improvement in the treated group or in any treated patient when individual test scores were analyzed. These findings indicate that oxiracetam is ineffective in reducing cognitive impairment due to Alzheimer's disease.

[1]  P. Mölsä,et al.  Senile dementia of the Alzheimer type treated with aniracetam: a new nootropic agent , 2004, Psychopharmacology.

[2]  Nootropic drugs in Alzheimer's disease , 1991, Neurology.

[3]  P. M. Monici Preti,et al.  Selegiline versus oxiracetam in patients with Alzheimer-type dementia. , 1990, Clinical therapeutics.

[4]  J. Deveaugh-Geiss,et al.  Oxiracetam in the treatment of multi-infarct dementia , 1989, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[5]  M. Albert,et al.  Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. , 1989, JAMA.

[6]  G. Maina,et al.  Oxiracetam in the treatment of primary degenerative and multi-infarct dementia: a double-blind, placebo-controlled study. , 1989, Neuropsychobiology.

[7]  G. Pepeu,et al.  Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine , 1987, Pharmacology Biochemistry and Behavior.

[8]  M. Quattropani,et al.  Clinical and neuropsychological study with oxiracetam versus placebo in patients with mild to moderate dementia. , 1987, Journal of neural transmission. Supplementum.

[9]  G. Pepeu,et al.  Oxiracetam prevents electroshock-induced decrease in brain acetylcholine and amnesia. , 1986, European journal of pharmacology.

[10]  E. Sinforiani,et al.  Activity of Oxiracetam in Patients with Organic Brain Syndrome: A Neuropsychological Study , 1986, Clinical neuropharmacology.

[11]  W. Classen,et al.  Effects of Oxiracetam on Learning and Memory in Animals: Comparison with Piracetam , 1986, Clinical neuropharmacology.

[12]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[13]  E. Kaplan,et al.  The Boston naming test , 2001 .

[14]  A. Benton.  Contributions to Neuropsychological Assessment: A Clinical Manual , 1983 .

[15]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[16]  HERMAN BUSCHKE,et al.  Evaluating storage, retention, and retrieval in disordered memory and learning , 1974, Neurology.

[17]  P. Osterrieth.  Le test de copie d'une figure complexe , 1944 .