Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6
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Davide Pirolli | G. Scambia | M. D. De Rosa | D. Gallo | A. Battaglia | M. Petrillo | Flavia Filippetti | Benedetta Righino | Marta de Donato | D. Pirolli
[1] R. Couñago,et al. In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. , 2018, MedChemComm.
[2] R. Bayliss,et al. Mitotic Regulation by NEK Kinase Networks , 2017, Front. Cell Dev. Biol..
[3] M. Schapira,et al. A systematic analysis of atomic protein–ligand interactions in the PDB , 2017, MedChemComm.
[4] K. Webber,et al. Chemotherapy for epithelial ovarian, fallopian tube and primary peritoneal cancer. , 2017, Best practice & research. Clinical obstetrics & gynaecology.
[5] Emanuel J. V. Gonçalves,et al. A Landscape of Pharmacogenomic Interactions in Cancer , 2016, Cell.
[6] R. Roskoski. Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes. , 2016, Pharmacological research.
[7] T. Mak,et al. Targeting Mitosis in Cancer: Emerging Strategies. , 2015, Molecular cell.
[8] G. Scambia,et al. Nek6 and Hif-1α cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer. , 2015, American journal of cancer research.
[9] M. Gottesman,et al. Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients. , 2015, Journal of inorganic biochemistry.
[10] J. Kobarg,et al. Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity , 2015, Molecules.
[11] James D. Brenton,et al. Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes , 2014, PloS one.
[12] J. Kobarg,et al. "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases. , 2014, World journal of biological chemistry.
[13] Xavier Robert,et al. Deciphering key features in protein structures with the new ENDscript server , 2014, Nucleic Acids Res..
[14] M. Kubbutat,et al. Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. , 2014, Journal of natural products.
[15] M. Diederich,et al. Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. , 2014, Journal of natural products.
[16] P. Perumal,et al. Discovery of Novel Inhibitors for Nek6 Protein through Homology Model Assisted Structure Based Virtual Screening and Molecular Docking Approaches , 2014, TheScientificWorldJournal.
[17] R. Bayliss,et al. Cell cycle regulation by the NEK family of protein kinases , 2012, Journal of Cell Science.
[18] Michael M. Mysinger,et al. Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking , 2012, Journal of medicinal chemistry.
[19] Jacob de Vlieg,et al. Comparative Analysis of Pharmacophore Screening Tools , 2012, J. Chem. Inf. Model..
[20] Joost C. M. Uitdehaag,et al. A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets , 2012, British journal of pharmacology.
[21] V. Stambolic,et al. Nek family of kinases in cell cycle, checkpoint control and cancer , 2011, Cell Division.
[22] F. Totzke,et al. Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. , 2011, Bioorganic & medicinal chemistry.
[23] G. Wani,et al. Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells , 2011, Molecular Cancer.
[24] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[25] R. Kiss,et al. Quercetin inhibits a large panel of kinases implicated in cancer cell biology. , 2011, International journal of oncology.
[26] Júlio C. Silva,et al. Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain , 2011, BMC Structural Biology.
[27] R. Ganapathi,et al. CCL2 expression in primary ovarian carcinoma is correlated with chemotherapy response and survival outcomes. , 2010, Anticancer research.
[28] F. Fiorentini,et al. 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors. , 2010, Bioorganic & medicinal chemistry letters.
[29] J. Kobarg,et al. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. , 2010, Journal of proteome research.
[30] David S. Goodsell,et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..
[31] R. Bayliss,et al. An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 , 2009, Molecular cell.
[32] F. Couch,et al. Edinburgh Research Explorer Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma , 2022 .
[33] A. Isacchi,et al. Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. , 2009, Journal of medicinal chemistry.
[34] Ian Collins,et al. Measuring and interpreting the selectivity of protein kinase inhibitors , 2009, Journal of chemical biology.
[35] A. Fry,et al. The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis , 2009, Molecular and Cellular Biology.
[36] Mark W. Richards,et al. Insights into the Conformational Variability and Regulation of Human Nek2 Kinase , 2009, Journal of molecular biology.
[37] Thomas A. Halgren,et al. Identifying and Characterizing Binding Sites and Assessing Druggability , 2009, J. Chem. Inf. Model..
[38] A. Groen,et al. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation , 2008, Journal of Cell Science.
[39] Joo-In Park,et al. Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation , 2008, Cell cycle.
[40] S. Deacon,et al. The challenge of selecting protein kinase assays for lead discovery optimization , 2008, Expert opinion on drug discovery.
[41] T. Schwede,et al. Protein structure homology modeling using SWISS-MODEL workspace , 2008, Nature Protocols.
[42] Manfred J. Sippl,et al. Thirty years of environmental health research--and growing. , 1996, Nucleic Acids Res..
[43] Ting-Chao Chou,et al. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.
[44] John Kuriyan,et al. An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor , 2006, Cell.
[45] Kevan M Shokat,et al. Features of selective kinase inhibitors. , 2005, Chemistry & biology.
[46] Michel F Sanner,et al. A component-based software environment for visualizing large macromolecular assemblies. , 2005, Structure.
[47] Thierry Langer,et al. LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters , 2005, J. Chem. Inf. Model..
[48] Brian K. Shoichet,et al. ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..
[49] D. Voehringer,et al. The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis* , 2003, Journal of Biological Chemistry.
[50] J. Avruch,et al. A Mitotic Cascade of NIMA Family Kinases , 2003, Journal of Biological Chemistry.
[51] Renxiao Wang,et al. Comparative evaluation of 11 scoring functions for molecular docking. , 2003, Journal of medicinal chemistry.
[52] G. Bemis,et al. Kinase inhibitors and the case for CH…O hydrogen bonds in protein–ligand binding , 2002, Proteins.
[53] E. Feige,et al. Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. , 2000, Genomics.
[54] J. Kuriyan,et al. Structures of Src-family tyrosine kinases. , 1997, Current opinion in structural biology.
[55] Thomas L. Madden,et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.
[56] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[57] D. Eisenberg,et al. VERIFY3D: assessment of protein models with three-dimensional profiles. , 1997, Methods in enzymology.
[58] Z. Derewenda,et al. The occurrence of C-H...O hydrogen bonds in proteins. , 1995, Journal of molecular biology.
[59] T. Blundell,et al. Comparative protein modelling by satisfaction of spatial restraints. , 1993, Journal of molecular biology.
[60] D S Moss,et al. Main-chain bond lengths and bond angles in protein structures. , 1993, Journal of molecular biology.
[61] D. Eisenberg,et al. Assessment of protein models with three-dimensional profiles , 1992, Nature.
[62] T. Chou,et al. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.