Regulation of bacterial virulence by two-component systems.

[1]  Mode of Action of the Bordetella BvgA Protein: Transcriptional Activation and Repression of the Bordetella bronchiseptica bipA Promoter , 2005, Journal of bacteriology.

[2]  M. Vergassola,et al.  VirR, a response regulator critical for Listeria monocytogenes virulence , 2005, Molecular microbiology.

[3]  J. Slauch,et al.  HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium , 2005, Molecular microbiology.

[4]  E. Groisman,et al.  The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica , 2005, Molecular microbiology.

[5]  E. Greenberg,et al.  The two‐component response regulator PprB modulates quorum‐sensing signal production and global gene expression in Pseudomonas aeruginosa , 2005, Molecular microbiology.

[6]  U. H. Stroeher,et al.  The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[7]  N. Carbonetti,et al.  Pertussis Toxin and Adenylate Cyclase Toxin Provide a One-Two Punch for Establishment of Bordetella pertussis Infection of the Respiratory Tract , 2005, Infection and Immunity.

[8]  D. Beier,et al.  Construction and Characterization of Listeria monocytogenes Mutants with In-Frame Deletions in the Response Regulator Genes Identified in the Genome Sequence , 2005, Infection and Immunity.

[9]  F. Fang,et al.  Co‐regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ , 2005, Molecular microbiology.

[10]  P. Cotter,et al.  BvgA functions as both an activator and a repressor to control Bvgi phase expression of bipA in Bordetella pertussis , 2005, Molecular microbiology.

[11]  D. Wozniak,et al.  The BvgAS Signal Transduction System Regulates Biofilm Development in Bordetella , 2005, Journal of bacteriology.

[12]  J. Connolly,et al.  A Three-Component Regulatory System Regulates Biofilm Maturation and Type III Secretion in Pseudomonas aeruginosa , 2005, Journal of bacteriology.

[13]  D. Kasper,et al.  Regulation of Virulence by a Two-Component System in Group B Streptococcus , 2005, Journal of bacteriology.

[14]  Nuria Vergara-Irigaray,et al.  Evaluation of the Role of the Bvg Intermediate Phase in Bordetella pertussis during Experimental Respiratory Infection , 2005, Infection and Immunity.

[15]  Luke E. Ulrich,et al.  One-component systems dominate signal transduction in prokaryotes. , 2005, Trends in microbiology.

[16]  S. Lory,et al.  A novel two‐component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes , 2004, Molecular microbiology.

[17]  S. Stibitz,et al.  Demonstration of differential virulence gene promoter activation in vivo in Bordetella pertussis using RIVET , 2004, Molecular microbiology.

[18]  S. Falkow,et al.  The Campylobacter jejuni dccRS two‐component system is required for optimal in vivo colonization but is dispensable for in vitro growth , 2004, Molecular microbiology.

[19]  M. Vergassola,et al.  CovS/CovR of group B streptococcus: a two‐component global regulatory system involved in virulence , 2004, Molecular microbiology.

[20]  J. Glasner,et al.  Regulation of Iron Transport in Streptococcus pneumoniae by RitR, an Orphan Response Regulator , 2004, Journal of bacteriology.

[21]  B. Kazmierczak,et al.  A novel sensor kinase–response regulator hybrid regulates type III secretion and is required for virulence in Pseudomonas aeruginosa , 2004, Molecular microbiology.

[22]  S. Lory,et al.  A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. , 2004, Developmental cell.

[23]  L. Kenney,et al.  The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2 , 2004, Molecular microbiology.

[24]  E. Groisman,et al.  Activation of the RcsC/YojN/RcsB phosphorelay system attenuates Salmonella virulence , 2004, Molecular microbiology.

[25]  Akinori Kato,et al.  Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. , 2004, Genes & development.

[26]  Eduardo A. Groisman,et al.  Transcriptional Control of the Antimicrobial Peptide Resistance ugtL Gene by the Salmonella PhoP and SlyA Regulatory Proteins* , 2004, Journal of Biological Chemistry.

[27]  J. Casadesús,et al.  Repression of the RcsC‐YojN‐RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence , 2004, Molecular microbiology.

[28]  J. Bliska,et al.  The Response Regulator PhoP of Yersinia pseudotuberculosis Is Important for Replication in Macrophages and for Virulence , 2004, Infection and Immunity.

[29]  T. Mitchell,et al.  Control of Virulence by the Two-Component System CiaR/H Is Mediated via HtrA, a Major Virulence Factor of Streptococcus pneumoniae , 2004, Journal of bacteriology.

[30]  D. Stephens,et al.  The MisR/MisS Two-component Regulatory System Influences Inner Core Structure and Immunotype of Lipooligosaccharide in Neisseria meningitidis* , 2004, Journal of Biological Chemistry.

[31]  E. Groisman,et al.  The PmrA-Regulated pmrC Gene Mediates Phosphoethanolamine Modification of Lipid A and Polymyxin Resistance in Salmonella enterica , 2004, Journal of bacteriology.

[32]  D. Beier,et al.  Genetic evidence for histidine kinase HP165 being an acid sensor of Helicobacter pylori. , 2004, FEMS microbiology letters.

[33]  Ralph Schlapbach,et al.  Genome‐wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori , 2004, Molecular microbiology.

[34]  H. Monteil,et al.  Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. , 2004, FEMS microbiology reviews.

[35]  A. Witney,et al.  A two‐component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae , 2004, Molecular microbiology.

[36]  J. Hoch,et al.  Developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms. , 2004, Current medicinal chemistry.

[37]  D. Saini,et al.  Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. , 2004, FEMS microbiology letters.

[38]  B. Ahmer,et al.  Pathways Leading from BarA/SirA to Motility andVirulence Gene Expression inSalmonella , 2003, Journal of bacteriology.

[39]  T. Latifi,et al.  Signal-dependent Requirement for the Co-activator Protein RcsA in Transcription of the RcsB-regulated ugd Gene* , 2003, Journal of Biological Chemistry.

[40]  T. Merkel,et al.  Analysis of bvgR Expression in Bordetella pertussis , 2003, Journal of bacteriology.

[41]  P. Andrew,et al.  The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae , 2003, Infection and Immunity.

[42]  C. Wolz,et al.  Molecular Architecture of the Regulatory Locus sae of Staphylococcus aureus and Its Impact on Expression of Virulence Factors , 2003, Journal of bacteriology.

[43]  N. Carbonetti,et al.  Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization by Bordetella pertussis , 2003, Infection and Immunity.

[44]  Samuel I. Miller,et al.  Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides , 2003, Molecular microbiology.

[45]  N. Sengupta,et al.  The Global Regulator ArcA Modulates Expression of Virulence Factors in Vibrio cholerae , 2003, Infection and Immunity.

[46]  G. Segal,et al.  Identification of CpxR as a Positive Regulator of icm and dot Virulence Genes of Legionella pneumophila , 2003, Journal of bacteriology.

[47]  Allison M. Jones,et al.  Phosphorelay control of virulence gene expression in Bordetella. , 2003, Trends in microbiology.

[48]  A. Charbit,et al.  Identification of the agr Locus of Listeria monocytogenes: Role in Bacterial Virulence , 2003, Infection and Immunity.

[49]  D. Holden,et al.  Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system , 2003, Cellular microbiology.

[50]  Jeffrey Green,et al.  PhoP-Responsive Expression of the Salmonella enterica Serovar Typhimurium slyA Gene , 2003, Journal of bacteriology.

[51]  R. Novick Autoinduction and signal transduction in the regulation of staphylococcal virulence , 2003, Molecular microbiology.

[52]  Tanya Parish,et al.  The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. , 2003, Microbiology.

[53]  L. Kenney,et al.  Dual regulation by phospho‐OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2 , 2003, Molecular microbiology.

[54]  Kayo Okumura,et al.  The VirR/VirS regulatory cascade affects transcription of plasmid-encoded putative virulence genes in Clostridium perfringens strain 13. , 2003, FEMS microbiology letters.

[55]  Akinori Kato,et al.  Closing the loop: The PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[56]  G. Segal,et al.  The Legionella pneumophila GacA homolog (LetA) is involved in the regulation of icm virulence genes and is required for intracellular multiplication in Acanthamoeba castellanii. , 2003, Microbial pathogenesis.

[57]  M. Wessels,et al.  The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+ , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[58]  E. Groisman,et al.  Control of the Salmonella ugd gene by three two‐component regulatory systems , 2003, Molecular microbiology.

[59]  S. Stibitz,et al.  The response regulator BvgA and RNA polymerase alpha subunit C-terminal domain bind simultaneously to different faces of the same segment of promoter DNA. , 2003, Molecular cell.

[60]  Christopher E. Wozniak,et al.  Functional Analysis of the Mycobacterium tuberculosis MprAB Two-Component Signal Transduction System , 2003 .

[61]  Russell Maurer,et al.  Intestinal short‐chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA , 2002, Molecular microbiology.

[62]  Yung-Hua Li,et al.  Novel Two-Component Regulatory System Involved in Biofilm Formation and Acid Resistance in Streptococcus mutans , 2002, Journal of bacteriology.

[63]  J. Musser,et al.  Virulence control in group A Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modeling , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[64]  J. Hoch,et al.  Two-component and phosphorelay signal-transduction systems as therapeutic targets. , 2002, Current opinion in pharmacology.

[65]  J. Garin,et al.  The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[66]  J. Mattick,et al.  Phosphorylation of the Pseudomonas aeruginosa Response Regulator AlgR Is Essential for Type IV Fimbria-Mediated Twitching Motility , 2002, Journal of bacteriology.

[67]  Andreas Bock,et al.  The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier. , 2002, European journal of biochemistry.

[68]  R. Gross,et al.  Identification and genomic organization of gene loci negatively controlled by the virulence regulatory BvgAS two-component system in Bordetella bronchiseptica , 2002, Molecular Genetics and Genomics.

[69]  C. Locht,et al.  Transient Requirement of the PrrA-PrrB Two-Component System for Early Intracellular Multiplication of Mycobacterium tuberculosis , 2002, Infection and Immunity.

[70]  K. Varughese,et al.  Molecular recognition of bacterial phosphorelay proteins. , 2002, Current opinion in microbiology.

[71]  Kim D Janda,et al.  Histidine kinases as targets for new antimicrobial agents. , 2002, Bioorganic & medicinal chemistry.

[72]  G. Rapoport,et al.  The two‐component system ArlS–ArlR is a regulator of virulence gene expression in Staphylococcus aureus , 2001, Molecular microbiology.

[73]  Ann M Stock,et al.  Histidine kinases and response regulator proteins in two-component signaling systems. , 2001, Trends in biochemical sciences.

[74]  R. L. Lucas,et al.  Roles of hilC and hilD in Regulation of hilA Expression in Salmonella enterica Serovar Typhimurium , 2001, Journal of bacteriology.

[75]  N. Carbonetti,et al.  Differential Regulation of Bvg-Activated Virulence Factors Plays a Role in Bordetella pertussisPathogenicity , 2001, Infection and Immunity.

[76]  Eduardo A. Groisman,et al.  The Pleiotropic Two-Component Regulatory System PhoP-PhoQ , 2001, Journal of bacteriology.

[77]  J. McCormick,et al.  Identification of a Novel Two-Component Regulatory System That Acts in Global Regulation of Virulence Factors ofStaphylococcus aureus , 2001, Journal of bacteriology.

[78]  Jeff F. Miller,et al.  Identification and characterization of BipA, a Bordetella Bvg‐intermediate phase protein , 2001, Molecular microbiology.

[79]  C. Altier,et al.  Regulation of Salmonella entericaSerovar Typhimurium Invasion Genes by csrA , 2000, Infection and Immunity.

[80]  E. Groisman,et al.  A Signal Transduction System that Responds to Extracellular Iron , 2000, Cell.

[81]  J. Galán,et al.  Striking a balance: modulation of the actin cytoskeleton by Salmonella. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[82]  E. Groisman,et al.  A small protein that mediates the activation of a two‐component system by another two‐component system , 2000, The EMBO journal.

[83]  J. Foster,et al.  OmpR Regulates the Stationary-Phase Acid Tolerance Response of Salmonella enterica Serovar Typhimurium , 2000, Journal of bacteriology.

[84]  C. Hill,et al.  Identification and Disruption of lisRK, a Genetic Locus Encoding a Two-Component Signal Transduction System Involved in Stress Tolerance and Virulence in Listeria monocytogenes , 1999, Journal of bacteriology.

[85]  E. Lin,et al.  Signal Decay through a Reverse Phosphorelay in the Arc Two-component Signal Transduction System* , 1998, The Journal of Biological Chemistry.

[86]  S Falkow,et al.  Macrophage‐dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival , 1998, Molecular microbiology.

[87]  Haruo Watanabe,et al.  Identification of cpxR as a Positive Regulator Essential for Expression of the Shigella sonnei virF Gene , 1998, Journal of bacteriology.

[88]  E. Moreno,et al.  A two‐component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence , 1998, Molecular microbiology.

[89]  V. Weiss,et al.  Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C‐terminal HPt domains of the sensor proteins , 1998, Molecular microbiology.

[90]  D. Wozniak,et al.  Identification of the Histidine Protein Kinase KinB inPseudomonas aeruginosa and Its Phosphorylation of the Alginate Regulator AlgB* , 1997, The Journal of Biological Chemistry.

[91]  Jeff F. Miller,et al.  Central Role of the BvgS Receiver as a Phosphorylated Intermediate in a Complex Two-component Phosphorelay* , 1996, The Journal of Biological Chemistry.

[92]  R. L. Lucas,et al.  Co‐ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression , 1996, Molecular microbiology.

[93]  E. Brunskill,et al.  Identification of LytSR-regulated genes from Staphylococcus aureus , 1996, Journal of bacteriology.

[94]  R. Rappuoli,et al.  Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase , 1996, Molecular microbiology.

[95]  A. Ullmann,et al.  Phosphorylation‐dependent binding of BvgA to the upstream region of the cyaA gene of Bordetella pertussis , 1996, Molecular microbiology.

[96]  Jeff F. Miller,et al.  Integration of multiple domains in a two‐component sensor protein: the Bordetella pertussis BvgAS phosphorelay. , 1996, The EMBO journal.

[97]  Jeff F. Miller,et al.  Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction , 1995, Cell.

[98]  J. Miller,et al.  BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model , 1994, Infection and immunity.

[99]  R. Rappuoli,et al.  Sequential activation and environmental regulation of virulence genes in Bordetella pertussis. , 1991, The EMBO journal.

[100]  P. Sansonetti,et al.  The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri , 1990, Journal of bacteriology.

[101]  B. Lacey Antigenic modulation of Bordetella pertussis , 1960, Journal of Hygiene.