Rationale for treating primary Sjögren’s syndrome patients with an anti-CD6 monoclonal antibody (Itolizumab)

[1]  J. Pers,et al.  Diagnostic value of labial minor salivary gland biopsy for Sjögren's syndrome: a systematic review. , 2013, Autoimmunity reviews.

[2]  Namrata Singh,et al.  The T cell in Sjogren's syndrome: force majeure, not spectateur. , 2012, Journal of autoimmunity.

[3]  J. Pers,et al.  B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment. , 2012, Journal of autoimmunity.

[4]  Y. Shoenfeld,et al.  Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjögren's syndrome. , 2012, Journal of autoimmunity.

[5]  J. Pers,et al.  CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. , 2012, Autoimmunity reviews.

[6]  J. Pers,et al.  Epigenetics and Sjögren's syndrome. , 2012, Current pharmaceutical biotechnology.

[7]  L. Essioux,et al.  CD6 and Syntaxin Binding Protein 6 Variants and Response to Tumor Necrosis Factor Alpha Inhibitors in Danish Patients with Rheumatoid Arthritis , 2012, PloS one.

[8]  J. Pers,et al.  Neurological Disorders in Primary Sjögren's Syndrome , 2012, Autoimmune diseases.

[9]  J. Anaya,et al.  HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. , 2012, Autoimmunity reviews.

[10]  J. Pers,et al.  In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation. , 2012, Autoimmunity reviews.

[11]  S. Davis,et al.  CD6 attenuates early and late signaling events, setting thresholds for T-cell activation , 2011, European journal of immunology.

[12]  E. Montero,et al.  A clinical exploratory study with itolizumab, an anti-CD6 monoclonal antibody, in patients with rheumatoid arthritis. , 2012, Results in immunology.

[13]  P. D. De Jager,et al.  The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation , 2011, The Journal of Immunology.

[14]  J. Reichert Antibody-based therapeutics to watch in 2011 , 2011, mAbs.

[15]  J. Pers,et al.  Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases , 2011, Arthritis.

[16]  J. Ellwart,et al.  The CD6 Scavenger Receptor Is Differentially Expressed on a CD56dim Natural Killer Cell Subpopulation and Contributes to Natural Killer-Derived Cytokine and Chemokine Secretion , 2010, Journal of Innate Immunity.

[17]  L. Misery,et al.  Memory B-cell aggregates in skin biopsy are diagnostic for primary Sjögren's syndrome. , 2010, Journal of autoimmunity.

[18]  J. Pers,et al.  Significance of B cells and B cell clonality in Sjögren's syndrome. , 2010, Arthritis and rheumatism.

[19]  H. Moutsopoulos,et al.  Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome. , 2010, Journal of autoimmunity.

[20]  J. Pers,et al.  Epigenetics and autoimmunity. , 2010, Journal of autoimmunity.

[21]  Ludwig Kappos,et al.  Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci , 2009, Nature Genetics.

[22]  J. Pers,et al.  Ectopic Germinal Centers Are Rare in Sjögren’s Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells1 , 2009, The Journal of Immunology.

[23]  N. Patel,et al.  Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb. , 2008, The Journal of allergy and clinical immunology.

[24]  Glay Chinea,et al.  Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. , 2008, Hybridoma.

[25]  Danica Stanimirovic,et al.  Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system , 2008, Nature Immunology.

[26]  J. Pers,et al.  BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome. , 2007, Arthritis and rheumatism.

[27]  A. Peixoto,et al.  Extracellular Isoforms of CD6 Generated by Alternative Splicing Regulate Targeting of CD6 to the Immunological Synapse1 , 2007, The Journal of Immunology.

[28]  B. Cochener,et al.  Improvement of Sjögren's syndrome after two infusions of rituximab (anti-CD20). , 2007, Arthritis and rheumatism.

[29]  J. Pers,et al.  Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome. , 2006, Arthritis and rheumatism.

[30]  P. Youinou,et al.  Role of B-cell antigen receptor-associated molecules and lipid rafts in CD5-induced apoptosis of B CLL cells , 2005, Leukemia.

[31]  R. Pérez,et al.  Humanization of predicted T-cell epitopes reduces the immunogenicity of chimeric antibodies: new evidence supporting a simple method. , 2003, Hybridoma and hybridomics.

[32]  R. Jonsson,et al.  Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group , 2002, Annals of the rheumatic diseases.

[33]  L. Beretta,et al.  CD6: expression during development, apoptosis and selection of human and mouse thymocytes. , 2002, International immunology.

[34]  T. Behrens,et al.  Cd5 Maintains Tolerance in Anergic B Cells , 2000, The Journal of experimental medicine.

[35]  E. Montero,et al.  CD6 molecule may be important in the pathological mechanisms of lymphocytes adhesion to human skin in psoriasis and ior t1 MAb a possible new approach to treat this disease. , 1999, Autoimmunity.

[36]  A. Grinberg,et al.  CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity , 1998, The Journal of experimental medicine.

[37]  D. Patel,et al.  Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium. , 1998, Arthritis and rheumatism.

[38]  H. Mellstedt,et al.  CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. , 1997, Blood.

[39]  T. Daniels Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. , 1984, Arthritis and rheumatism.