Alternative splicing and cancer: a systematic review

[1]  Z. Israel,et al.  Reversing a Model of Parkinson's Disease With In Situ Converted Nigral Neurons , 2020, Movement disorders : official journal of the Movement Disorder Society.

[2]  Ravindra N. Singh,et al.  RNA in spinal muscular atrophy: therapeutic implications of targeting , 2020, Expert opinion on therapeutic targets.

[3]  Maliheh Movassat,et al.  Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly , 2020, RNA.

[4]  Dongyang Zhang,et al.  Reversing Parkinson Disease Model with in situ Converted Nigral Neurons , 2020, Nature.

[5]  Tai-Heng Chen New and Developing Therapies in Spinal Muscular Atrophy: From Genotype to Phenotype to Treatment and Where Do We Stand? , 2020, International journal of molecular sciences.

[6]  J. Valcárcel,et al.  Roles and mechanisms of alternative splicing in cancer — implications for care , 2020, Nature Reviews Clinical Oncology.

[7]  Huatai Xu,et al.  Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice , 2020, Cell.

[8]  C. Imbriano,et al.  Transcription Factors in Cancer: When Alternative Splicing Determines Opposite Cell Fates , 2020, Cells.

[9]  A. Kaneda,et al.  Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer , 2020, Oncogenesis.

[10]  Qun Zhou,et al.  miR‐335 modulates Numb alternative splicing via targeting RBM10 in endometrial cancer , 2020, The Kaohsiung journal of medical sciences.

[11]  Qun Zhou,et al.  Alternative splicing of VEGFA is regulated by RBM10 in endometrial cancer , 2020, The Kaohsiung journal of medical sciences.

[12]  Michael A. Freitas,et al.  The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia , 2019, Nature Communications.

[13]  V. Visconte,et al.  Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features , 2019, Cancers.

[14]  Y. Gong,et al.  Prognostic value of U2AF1 mutant in patients with de novo myelodysplastic syndromes: a meta-analysis , 2019, Annals of Hematology.

[15]  Mengyuan Li,et al.  Downregulation of HNRNPK in human cancer cells inhibits lung metastasis , 2019, Animal models and experimental medicine.

[16]  John A. Calarco,et al.  Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma , 2019, Nature.

[17]  Julio Delgado,et al.  The U1 spliceosomal RNA is recurrently mutated in multiple cancers , 2019, Nature.

[18]  Alexander V Penson,et al.  Spliceosomal disruption of the non-canonical BAF complex in cancer , 2019, Nature.

[19]  Justin Taylor,et al.  Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies , 2019, Genes, chromosomes & cancer.

[20]  Yuting Chen,et al.  Role of heterogeneous nuclear ribonucleoprotein K in tumor development , 2019, Journal of cellular biochemistry.

[21]  D. Baltimore,et al.  Alternative mRNA splicing in cancer immunotherapy , 2019, Nature Reviews Immunology.

[22]  Yan-ping Zhang,et al.  Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  Jörg Menche,et al.  Mutational Landscape of the Transcriptome Offers Putative Targets for Immunotherapy of Myeloproliferative Neoplasms. , 2019, Blood.

[24]  Sara R. Selitsky,et al.  Alternative tumour-specific antigens , 2019, Nature Reviews Cancer.

[25]  Ryan L Setten,et al.  The current state and future directions of RNAi-based therapeutics , 2019, Nature Reviews Drug Discovery.

[26]  F. Wang,et al.  RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma. , 2019, Gene.

[27]  B. Eymin,et al.  Circular RNAs and RNA Splice Variants as Biomarkers for Prognosis and Therapeutic Response in the Liquid Biopsies of Lung Cancer Patients , 2019, Front. Genet..

[28]  Tianxin Lin,et al.  Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM. , 2019, Cancer letters.

[29]  Hong Yang,et al.  Role of global aberrant alternative splicing events in papillary thyroid cancer prognosis , 2019, Aging.

[30]  E. Levanon,et al.  Specific inhibition of splicing factor activity by decoy RNA oligonucleotides , 2019, Nature Communications.

[31]  Xin Di,et al.  RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway , 2019, Journal of cellular and molecular medicine.

[32]  Ke Chen,et al.  Genome-wide identification of cancer-specific alternative splicing in circRNA , 2019, Molecular Cancer.

[33]  M. Hafner,et al.  The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation , 2019, Genes & development.

[34]  Cencen Li,et al.  Post-translational modification control of RNA-binding protein hnRNPK function , 2019, Open Biology.

[35]  P. Spellman,et al.  Alternative Splicing in Tumors — A Path to Immunogenicity? , 2019, The New England journal of medicine.

[36]  T. Brümmendorf,et al.  Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region. , 2019, Leukemia research.

[37]  M. Ladomery,et al.  Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1 , 2019, Cells.

[38]  Angela N. Brooks,et al.  Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma , 2018, bioRxiv.

[39]  C. Stuelten,et al.  TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance , 2018, Oncogene.

[40]  R. Sadeghi,et al.  Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis , 2016, Hematology.

[41]  C. Gu,et al.  Functional role of RBM10 in lung adenocarcinoma proliferation , 2018, International journal of oncology.

[42]  Han Liu,et al.  SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance , 2018, EBioMedicine.

[43]  Benjamin G. Bitler,et al.  The long non‐coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2‐mediated alternative splicing , 2018, Molecular carcinogenesis.

[44]  Y. Li,et al.  HOTAIR, a long noncoding RNA, is a marker of abnormal cell cycle regulation in lung cancer , 2018, Cancer science.

[45]  F. Heyd,et al.  Characterization of cis-acting elements that control oscillating alternative splicing , 2018, RNA biology.

[46]  Steven J. M. Jones,et al.  Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients , 2018, Cancer cell.

[47]  J. Granados-Riverón,et al.  CRISPR-Cas13 Precision Transcriptome Engineering in Cancer. , 2018, Cancer research.

[48]  A. Ludolph,et al.  Antisense oligonucleotides in neurological disorders , 2018, Therapeutic advances in neurological disorders.

[49]  Jianwen Liu,et al.  PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing , 2018, Cell Death & Disease.

[50]  M. Gleave,et al.  Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells , 2018, Proceedings of the National Academy of Sciences.

[51]  G. Stefani,et al.  SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells , 2018, Leukemia.

[52]  Kang Zhang,et al.  SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. , 2018, Cell chemical biology.

[53]  S. E. Harvey,et al.  Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT , 2018, bioRxiv.

[54]  Rolf Backofen,et al.  MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions , 2018, bioRxiv.

[55]  M. Warmuth,et al.  H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers , 2018, Nature Medicine.

[56]  H. Kędzierska,et al.  microRNA‐mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3′UTRs , 2018, Experimental cell research.

[57]  Zhi-gang Zhang,et al.  SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis , 2018, Oncogene.

[58]  F. Ariel,et al.  Splicing regulation by long noncoding RNAs , 2018, Nucleic acids research.

[59]  Peter G. Smith,et al.  Targeting splicing abnormalities in cancer. , 2018, Current opinion in genetics & development.

[60]  N. Rosas-Murrieta,et al.  Alternative Splicing as a Target for Cancer Treatment , 2018, International journal of molecular sciences.

[61]  J. Blenis,et al.  Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling , 2017, Cell.

[62]  P. Khavari,et al.  The functions and unique features of long intergenic non-coding RNA , 2017, Nature Reviews Molecular Cell Biology.

[63]  J. Kjems,et al.  Circular RNAs in cancer: opportunities and challenges in the field , 2017, Oncogene.

[64]  Aviv Regev,et al.  RNA targeting with CRISPR–Cas13 , 2017, Nature.

[65]  V. Fauveau,et al.  Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity. , 2017, Journal of hepatology.

[66]  Adam Godzik,et al.  The Functional Impact of Alternative Splicing in Cancer. , 2017, Cell reports.

[67]  Rodney Hull,et al.  Abnormalities in alternative splicing in diabetes: therapeutic targets. , 2017, Journal of molecular endocrinology.

[68]  P. Howe,et al.  A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumor progression , 2017, Nature Cell Biology.

[69]  H. Kato,et al.  Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells , 2017, Scientific Reports.

[70]  R. Maruyama,et al.  LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblasts , 2017, Scientific Reports.

[71]  Minghua Wu,et al.  CircRNA: functions and properties of a novel potential biomarker for cancer , 2017, Molecular Cancer.

[72]  A. Masuda,et al.  Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction , 2017, Journal of neurochemistry.

[73]  Yang Zhang,et al.  Extensive translation of circular RNAs driven by N6-methyladenosine , 2017, Cell Research.

[74]  M. Jurica,et al.  Modulating splicing with small molecular inhibitors of the spliceosome , 2017, Wiley interdisciplinary reviews. RNA.

[75]  Zefeng Wang,et al.  SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling , 2017, Cell Research.

[76]  Xinwen Chen,et al.  MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication , 2017, PloS one.

[77]  E. Eyras,et al.  The role of alternative splicing in cancer , 2016, Transcription.

[78]  A. Fasano,et al.  Proinflammatory cytokine interferon‐γ and microbiome‐derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease , 2016, Clinical and experimental immunology.

[79]  Jung-Chun Lin,et al.  Differential Impacts of Alternative Splicing Networks on Apoptosis , 2016, International journal of molecular sciences.

[80]  Jon C. Aster,et al.  Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. , 2016, Cancer cell.

[81]  O. Abdel-Wahab,et al.  Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins , 2016, Clinical Cancer Research.

[82]  Jun Zhang,et al.  Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins. , 2016, Molecular cell.

[83]  J. Lucas,et al.  Faulty splicing and cytoskeleton abnormalities in Huntington's disease , 2016, Brain pathology.

[84]  M. Lai,et al.  Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. , 2016, Cancer letters.

[85]  M. Boutros,et al.  Wnt signaling in cancer , 2016, Oncogene.

[86]  D. Kent,et al.  Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts , 2016, Leukemia.

[87]  A. Krainer,et al.  Splicing-factor alterations in cancers , 2016, RNA.

[88]  Yigong Shi,et al.  Structure of a yeast activated spliceosome at 3.5 Å resolution , 2016, Science.

[89]  Chuangye Yan,et al.  Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution , 2016, Science.

[90]  Y. Dor,et al.  Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival , 2016, Scientific Reports.

[91]  S. Djurovic,et al.  A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia , 2016, Biological Psychiatry.

[92]  N. Basu,et al.  Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus , 2016, Arthritis Research & Therapy.

[93]  Jialing Rong,et al.  Expression of SRSF3 is Correlated with Carcinogenesis and Progression of Oral Squamous Cell Carcinoma , 2016, International journal of medical sciences.

[94]  Jun Zhang,et al.  Diverse alternative back-splicing and alternative splicing landscape of circular RNAs , 2016, Genome research.

[95]  Lei S. Qi,et al.  CRISPR/Cas9 in Genome Editing and Beyond. , 2016, Annual review of biochemistry.

[96]  Eunhee Kim,et al.  RNA splicing factors as oncoproteins and tumour suppressors , 2016, Nature Reviews Cancer.

[97]  V. Timmerman,et al.  The hnRNP family: insights into their role in health and disease , 2016, Human Genetics.

[98]  David R. Liu,et al.  Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage , 2016, Nature.

[99]  Y. Xu,et al.  Alternative splicing directs two IL-20R2 isoforms and is responsible for the incomplete gene knockout via the exon I ablation , 2016, Genes and Immunity.

[100]  Ling-Ling Chen The biogenesis and emerging roles of circular RNAs , 2016, Nature Reviews Molecular Cell Biology.

[101]  F. Stingo,et al.  Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS , 2016, Oncotarget.

[102]  Weining Yang,et al.  Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 , 2016, Nucleic acids research.

[103]  R. Sharan,et al.  A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1 , 2016, Genome research.

[104]  Liang Han,et al.  Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines. , 2016, Oncology reports.

[105]  Yigong Shi,et al.  The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis , 2016, Science.

[106]  M. McArthur,et al.  hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. , 2015, Cancer cell.

[107]  Yigong Shi,et al.  Structure of a yeast spliceosome at 3.6-angstrom resolution , 2015, Science.

[108]  Alexander V Penson,et al.  Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities , 2015, Proceedings of the National Academy of Sciences.

[109]  Eric J. Hayden,et al.  Alternative Splicing in Alzheimer’s Disease , 2015, Journal of Parkinson's disease and Alzheimer's disease.

[110]  G. Bressan,et al.  Splicing Regulators and Their Roles in Cancer Biology and Therapy , 2015, BioMed research international.

[111]  P. Campbell,et al.  SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts. , 2015, Blood.

[112]  P. Rohrlich,et al.  CD20 alternative splicing isoform generates immunogenic CD4 helper T epitopes , 2015, International journal of cancer.

[113]  D. Rio,et al.  Mechanisms and Regulation of Alternative Pre-mRNA Splicing. , 2015, Annual review of biochemistry.

[114]  Gil Ast,et al.  Regulation of alternative splicing through coupling with transcription and chromatin structure. , 2015, Annual review of biochemistry.

[115]  R. Fulton,et al.  Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. , 2015, Cancer cell.

[116]  G. Shan,et al.  Exon-intron circular RNAs regulate transcription in the nucleus , 2015, Nature Structural &Molecular Biology.

[117]  Yang Wang,et al.  Efficient backsplicing produces translatable circular mRNAs , 2015, RNA.

[118]  M. Hagiwara,et al.  Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases. , 2015, ACS chemical biology.

[119]  S. Miyano,et al.  Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome , 2014, Nature Communications.

[120]  Pengfei Li,et al.  Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells , 2014, Genes.

[121]  D. Bates,et al.  Hallmarks of alternative splicing in cancer , 2014, Oncogene.

[122]  L. Ding,et al.  U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing , 2014, Leukemia.

[123]  C. Sette,et al.  Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection , 2014, Nucleic acids research.

[124]  N. Rajewsky,et al.  circRNA biogenesis competes with pre-mRNA splicing. , 2014, Molecular cell.

[125]  Jung-Chun Lin,et al.  Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events , 2014, RNA.

[126]  C. Lorson,et al.  Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. , 2014, Human molecular genetics.

[127]  M. Ares,et al.  Context-dependent control of alternative splicing by RNA-binding proteins , 2014, Nature Reviews Genetics.

[128]  Jing Fang,et al.  BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells , 2014, Nature Communications.

[129]  Alessandra Montecucco,et al.  The alternative splicing side of cancer. , 2014, Seminars in cell & developmental biology.

[130]  F. Hou,et al.  Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex , 2014, British Journal of Cancer.

[131]  Chonghui Cheng,et al.  Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing , 2014, Genes & development.

[132]  S. Limborska,et al.  Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson's Disease , 2014, BioMed research international.

[133]  L. Zender,et al.  Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development , 2014, RNA.

[134]  S. Ogawa,et al.  Splicing factor mutations and cancer , 2014, Wiley interdisciplinary reviews. RNA.

[135]  Hu Zhu,et al.  The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth. , 2014, Cancer letters.

[136]  Zefeng Wang,et al.  The splicing activator DAZAP1 integrates splicing control into MEK/Erk regulated cell proliferation and migration , 2014, Nature Communications.

[137]  A. Krainer,et al.  Splicing factor SRSF6 promotes hyperplasia of sensitized skin , 2014, Nature Structural &Molecular Biology.

[138]  J. Valcárcel,et al.  RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation. , 2013, Molecular cell.

[139]  Seishi Ogawa,et al.  PRPF8 Defects Cause Missplicing in Myeloid Malignancies , 2014, Leukemia.

[140]  Shanshan Zhu,et al.  Circular intronic long noncoding RNAs. , 2013, Molecular cell.

[141]  D. Birnbaum,et al.  Prognostic score including gene mutations in chronic myelomonocytic leukemia. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[142]  E. Lara-Pezzi,et al.  The Alternative Heart: Impact of Alternative Splicing in Heart Disease , 2013, Journal of Cardiovascular Translational Research.

[143]  Douglas L Black,et al.  EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. , 2013, Cell metabolism.

[144]  Benjamin J. Raphael,et al.  Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. , 2013, The New England journal of medicine.

[145]  E. Stickeler,et al.  Alterations in Expression Pattern of Splicing Factors in Epithelial Ovarian Cancer and its Clinical Impact , 2013, International Journal of Gynecologic Cancer.

[146]  Xiang-Dong Fu,et al.  Regulation of splicing by SR proteins and SR protein-specific kinases , 2013, Chromosoma.

[147]  E Mardis,et al.  Clonal diversity of recurrently mutated genes in myelodysplastic syndromes , 2013, Leukemia.

[148]  J. Kjems,et al.  Natural RNA circles function as efficient microRNA sponges , 2013, Nature.

[149]  H. Gautrey,et al.  Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells , 2012, PloS one.

[150]  J. Valcárcel,et al.  The spliceosome as a target of novel antitumour drugs , 2012, Nature Reviews Drug Discovery.

[151]  J. D. Mills,et al.  The role of RNA structure in posttranscriptional regulation of gene expression. , 2012, Journal of genetics and genomics = Yi chuan xue bao.

[152]  Angela N. Brooks,et al.  Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing , 2012, Cell.

[153]  Ryan M. Plocinik,et al.  The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. , 2012, Molecular cell.

[154]  Norman E. Davey,et al.  Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins , 2012, Cell.

[155]  Yun-Ji Kim,et al.  Alternative Splicing and Its Impact as a Cancer Diagnostic Marker , 2012, Genomics & informatics.

[156]  Jing Li,et al.  Aberrant Expression of Splicing Factors in Newly Diagnosed Acute Myeloid Leukemia , 2012, Oncology Research and Treatment.

[157]  A. Jankowska,et al.  Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. , 2012, Blood.

[158]  Claude Preudhomme,et al.  Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. , 2012, Blood.

[159]  P. Ellinor,et al.  RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing , 2012, Nature Medicine.

[160]  I. Luzina,et al.  Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma. , 2012, Cytokine.

[161]  Paul Polakis,et al.  Wnt signaling in cancer. , 2012, Cold Spring Harbor perspectives in biology.

[162]  E. Giné,et al.  Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia , 2011, Nature Genetics.

[163]  A. Krainer,et al.  THE SPLICING FACTOR SRSF1 REGULATES APOPTOSIS AND PROLIFERATION TO PROMOTE MAMMARY EPITHELIAL CELL TRANSFORMATION , 2011, Nature Structural &Molecular Biology.

[164]  M. Stratton,et al.  Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. , 2011, The New England journal of medicine.

[165]  J. Bourke,et al.  Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study , 2011, The Lancet.

[166]  S. Mazurek Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. , 2011, The international journal of biochemistry & cell biology.

[167]  Hsien-Da Huang,et al.  Small Molecule Amiloride Modulates Oncogenic RNA Alternative Splicing to Devitalize Human Cancer Cells , 2011, PloS one.

[168]  M. Moore,et al.  Ordered and Dynamic Assembly of Single Spliceosomes , 2011, Science.

[169]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[170]  Chonghui Cheng,et al.  CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. , 2011, The Journal of clinical investigation.

[171]  R. Cancedda,et al.  17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease , 2011, Neurobiology of Disease.

[172]  J. Manley,et al.  Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. , 2010, Cancer research.

[173]  Amy J. Hawkins,et al.  Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. , 2010, Cancer research.

[174]  K. Lynch,et al.  Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. , 2010, Molecular cell.

[175]  C. Ghigna,et al.  Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene , 2010, The Journal of cell biology.

[176]  R. Kole,et al.  Anti-tumor activity of splice-switching oligonucleotides , 2010, Nucleic acids research.

[177]  D. Underhill,et al.  Identification of a Novel Human MD-2 Splice Variant That Negatively Regulates Lipopolysaccharide-Induced TLR4 Signaling , 2010, The Journal of Immunology.

[178]  S. Blackshaw,et al.  articleThe long noncoding RNA RNCR 2 directs mouse retinal cell specification , 2010 .

[179]  A. Mayeda,et al.  The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients , 2010, Neurochemistry International.

[180]  B. Blencowe,et al.  Regulation of Alternative Splicing by Histone Modifications , 2010, Science.

[181]  J. Vance,et al.  SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease , 2010, PloS one.

[182]  A. Krainer,et al.  SF2/ASF Autoregulation Involves Multiple Layers of Post-transcriptional and Translational Control , 2010, Nature Structural &Molecular Biology.

[183]  M. Assanah,et al.  HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer , 2010, Nature.

[184]  T. Nilsen,et al.  Expansion of the eukaryotic proteome by alternative splicing , 2010, Nature.

[185]  R. Huang,et al.  Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.

[186]  J. Manley,et al.  Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches , 2009, Nature Reviews Molecular Cell Biology.

[187]  P. Jordan,et al.  Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. , 2009, Human molecular genetics.

[188]  R. Kole,et al.  Therapeutic potential of splice-switching oligonucleotides. , 2009, Oligonucleotides.

[189]  P. Jordan,et al.  The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. , 2008, RNA.

[190]  B. Frey,et al.  Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing , 2008, Nature Genetics.

[191]  Steven J. Harper,et al.  VEGF-A splicing: the key to anti-angiogenic therapeutics? , 2008, Nature Reviews Cancer.

[192]  Ru Wei,et al.  The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth , 2008, Nature.

[193]  G. Perrone,et al.  Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. , 2007, Cancer research.

[194]  M. Pajares,et al.  Alternative splicing: an emerging topic in molecular and clinical oncology. , 2007, The Lancet. Oncology.

[195]  Nuno L Barbosa-Morais,et al.  Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion. , 2005, Genome research.

[196]  F. Clark,et al.  Understanding alternative splicing: towards a cellular code , 2005, Nature Reviews Molecular Cell Biology.

[197]  J. Lucas,et al.  Glycogen Synthase Kinase-3 Plays a Crucial Role in Tau Exon 10 Splicing and Intranuclear Distribution of SC35 , 2004, Journal of Biological Chemistry.

[198]  D. Black Mechanisms of alternative pre-messenger RNA splicing. , 2003, Annual review of biochemistry.

[199]  Melissa S Jurica,et al.  Pre-mRNA splicing: awash in a sea of proteins. , 2003, Molecular cell.

[200]  T. Cooper,et al.  Pre-mRNA splicing and human disease. , 2003, Genes & development.

[201]  P. Herrlich,et al.  Regulation of alternative pre‐mRNA splicing by the ERK MAP‐kinase pathway , 2001, The EMBO journal.

[202]  A Sureau,et al.  SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs , 2001, The EMBO journal.

[203]  P. Rakic,et al.  Mechanisms of programmed cell death in the developing brain , 2000, Trends in Neurosciences.

[204]  Michael R. Green,et al.  Functional recognition of the 3′ splice site AG by the splicing factor U2AF35 , 1999, Nature.

[205]  D. Warnock The epithelial sodium channel in hypertension , 1999, Current hypertension reports.

[206]  B. Stoddard,et al.  The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. , 1998, Structure.

[207]  T. Tanaka,et al.  Isolation and characterization of the human pyruvate kinase M gene. , 1991, European journal of biochemistry.

[208]  T. Maniatis,et al.  Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus , 1990, Nature.

[209]  P. Sharp,et al.  Spliced segments at the 5′ terminus of adenovirus 2 late mRNA* , 1977, Proceedings of the National Academy of Sciences.

[210]  James M. Roberts,et al.  A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids , 1977, Cell.

[211]  T. Link,et al.  Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas , 2020 .

[212]  L. Matos,et al.  RNA Therapeutics: How Far Have We Gone? , 2019, Advances in experimental medicine and biology.

[213]  T. Link,et al.  Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas. , 2019, Journal of the National Cancer Institute.

[214]  Ravindra N. Singh,et al.  Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes. , 2018, Advances in neurobiology.

[215]  Kate S. Carroll,et al.  Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure , 2015 .

[216]  Jonathan M. Howard,et al.  The RNAissance family: SR proteins as multifaceted regulators of gene expression , 2015, Wiley interdisciplinary reviews. RNA.

[217]  Anke Busch,et al.  Evolution of SR protein and hnRNP splicing regulatory factors , 2012, Wiley interdisciplinary reviews. RNA.

[218]  G. MacGregor,et al.  The Epithelial Sodium Channel in Hypertension , 2004 .

[219]  Alexandros D. Polydorides,et al.  The splice of life: Alternative splicing and neurological disease , 2001, Nature Reviews Neuroscience.