CYTOLOGICAL DIAGNOSIS OF FINE-NEEDLE PUNCTURE BIOPSIES OF THE THYROIDGLAND IN UKRAINE: COMPARIS ON WITH INTERNATIONAL PRACTICE

Thyroid cancer is one of the few cancers diagnosed by cytological examination of thin nodule puncture biopsies. To achieve standardization of diagnostic terminology, morphological criteria and risk of malignancy in the whole world, the 6-level Bethesda system is used. The work aimed to analyze the results of cytological examination of fine-needle aspiration puncture biopsies (TAPBs) of thyroid nodules according to the international Bethesda system for the last three years and compare them with the world practice. As a result, 5687 surveys were conducted, where the proportion of women was 87.9% and of men 12.1%. Of all the cases, the most extensive cytological findings were of class II (benign formation) - 3061 studies (57%). The number of cases interpreted as class III was within the reference values, i.e. 8.2%. The fourth class accounted for 8.2%, the fifth for 3.5%, and the sixth for 5.0%. In total, these three classes account for 17.2%. Our analysis compared the reference values and data from other laboratories revealed comparable results. The analysis of the structure of the results of cytological investigations according to Bethesda revealed a high rate of the first class (non-informative), which indicates the need for more accurate interaction between clinical physicists and cytologists.

[1]  P. Rodien,et al.  Sex Bias in Differentiated Thyroid Cancer , 2021, International journal of molecular sciences.

[2]  D. McFadden,et al.  Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms , 2021, Frontiers in Endocrinology.

[3]  E. Yousefi,et al.  The gray zone of thyroid nodules: Using a nomogram to provide malignancy risk assessment and guide patient management , 2021, Cancer medicine.

[4]  M. Daly,et al.  GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer , 2020, Nature Communications.

[5]  O. Sulaieva,et al.  Papillary thyroid cancer and thyroid stimulating hormone: does sex matter? , 2019, Fiziolohichnyĭ zhurnal.

[6]  B. Geramizadeh,et al.  Cytomorphologic, Imaging, Molecular Findings, and Outcome in Thyroid Follicular Lesion of Undetermined Significance/Atypical Cell of Undetermined Significance (AUS/FLUS): A Mini-Review , 2018, Acta Cytologica.

[7]  P. Almeida,et al.  Ultrasound requested by general practitioners or for symptoms unrelated to the thyroid gland may explain higher prevalence of thyroid nodules in females. , 2018, Clinical imaging.

[8]  P. Parrilla,et al.  Ultrasonographic risk factors of malignancy in thyroid nodules , 2016, Langenbeck's Archives of Surgery.

[9]  D. O’Connell,et al.  Predictors of non-diagnostic cytology in surgeon-performed ultrasound guided fine needle aspiration of thyroid nodules , 2014, Journal of Otolaryngology - Head & Neck Surgery.

[10]  I. Kholová,et al.  Thyroid Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance: An Indispensable Bethesda 2010 Diagnostic Category or Waste Garbage? , 2014, Acta Cytologica.

[11]  F. Schmitt,et al.  Role of ancillary studies in fine‐needle aspiration from selected tumors , 2012, Cancer cytopathology.

[12]  E. Cibas,et al.  The Bethesda System for Reporting Thyroid Cytopathology , 2009, Springer International Publishing.

[13]  G. Van Vliet,et al.  Sexual dimorphism of thyroid function in newborns with congenital hypothyroidism. , 2005, The Journal of clinical endocrinology and metabolism.