论文信息 - G-CSF Is a Cancer Stem Cell-Specific Growth Factor-Letter.

G-CSF Is a Cancer Stem Cell-Specific Growth Factor-Letter.

We read with interest the recent article by Agarwal and colleagues investigating the biologic significance of granulocyte colony stimulating factor (G-CSF) in stem-like subpopulations of neuroblastoma cells ([1][1]). While we find their observations provocative, and do not debate their demonstration

J. Maris | U. Pötschger | R. Ladenstein | Julie R. Park | J. Healy

[1] Eugene S. Kim,et al. G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation. , 2015, Cancer research.

[2] Julie R. Park,et al. Neuroblastoma: paradigm for precision medicine. , 2015, Pediatric clinics of North America.

[3] D. Machin,et al. Randomized Trial of prophylactic granulocyte colony-stimulating factor during rapid COJEC induction in pediatric patients with high-risk neuroblastoma: the European HR-NBL1/SIOPEN study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4] Wenge Lu,et al. Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. , 2004, Pharmacological research.

[5] K. Blesch,et al. Estimating the starting dose for entry into humans: principles and practice , 2002, European Journal of Clinical Pharmacology.