Cadherins and their connections: adhesion junctions have broader functions.

Cadherins - a family of cell-cell adhesion molecules - are linked to the actin cytoskeleton via intervening proteins. Recent results address molecular explanations for observed cadherin behavior, point to signals that regulate adhesion by modulating elements of the cadherin-associated complex, challenge the belief that different cadherins generally cannot cross-adhere, and highlight instructive roles for cadherins in cell signaling and differentiation.

[1]  Carien M. Niessen,et al.  The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn , 1998, The Journal of cell biology.

[2]  R Kemler,et al.  A role for cadherins in tissue formation. , 1996, Development.

[3]  W J Nelson,et al.  Cadherin cell adhesion molecules in differentiation and embryogenesis. , 1996, International review of cytology.

[4]  Shintaro T. Suzuki.  Structural and functional diversity of cadherin superfamily: Are new members of cadherin superfamily involved in signal transduction pathway? , 1996, Journal of cellular biochemistry.

[5]  N. Nomura,et al.  Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. , 1998, Science.

[6]  M. Takeichi,et al.  p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells , 1999, The Journal of cell biology.

[7]  R. Tuan,et al.  Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function. , 1999, Differentiation; research in biological diversity.

[8]  Kenneth M. Yamada,et al.  Modulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail. , 1998, Experimental cell research.

[9]  Takayoshi Inoue,et al.  Cadherin‐6 in the developing mouse brain: Expression along restricted connection systems and synaptic localization suggest a potential role in neuronal circuitry , 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

[10]  J. Papkoff,et al.  Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly , 1994, The Journal of cell biology.

[11]  L. Rubin,et al.  Dephosphorylation of the Cadherin-associated p100/p120 Proteins in Response to Activation of Protein Kinase C in Epithelial Cells* , 1997, The Journal of Biological Chemistry.

[12]  K. Knudsen,et al.  N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells. , 1997, Developmental biology.

[13]  B. Geiger,et al.  Direct involvement of N-cadherin-mediated signaling in muscle differentiation. , 1998, Molecular biology of the cell.

[14]  W. Moolenaar,et al.  Receptor protein tyrosine phosphatases: involvement in cell-cell interaction and signaling. , 1997, Biochimie.

[15]  A. Yap,et al.  The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. , 1998, Cancer investigation.

[16]  M. S. Steinberg,et al.  Measurement of tumor cell cohesion and suppression of invasion by E- or P-cadherin. , 1997, Cancer research.

[17]  K. Johnson,et al.  A role for cadherins in cellular signaling and differentiation , 1998, Journal of cellular biochemistry. Supplement.

[18]  Takayoshi Inoue,et al.  Neuronal Circuits Are Subdivided by Differential Expression of Type-II Classic Cadherins in Postnatal Mouse Brains , 1997, Molecular and Cellular Neuroscience.

[19]  M. Takeichi,et al.  Neural crest emigration from the neural tube depends on regulated cadherin expression. , 1998, Development.

[20]  G. Forgacs,et al.  Surface tensions of embryonic tissues predict their mutual envelopment behavior. , 1996, Development.

[21]  Z. Kam,et al.  p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry , 1999, Oncogene.

[22]  J. Cleveland,et al.  p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. , 1992, Oncogene.

[23]  O. Blaschuk,et al.  Identification of a cadherin cell adhesion recognition sequence. , 1990, Developmental biology.

[24]  Cynthia L. Adams,et al.  Mechanisms of Epithelial Cell–Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin– Green Fluorescent Protein , 1998, The Journal of cell biology.

[25]  R. Nusse,et al.  β-catenin: a key mediator of Wnt signaling , 1998 .

[26]  W. Birchmeier,et al.  V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift , 1995, The Journal of cell biology.

[27]  Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. , 1998 .

[28]  M. Itoh,et al.  Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion. , 1999 .

[29]  O. Blaschuk,et al.  N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis? , 1999, The American journal of pathology.

[30]  B. Gumbiner,et al.  Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function , 1997, Current Biology.

[31]  D L Rimm,et al.  Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[32]  W. Woodward,et al.  N-Cadherin expression and signaling in limb mesenchymal chondrogenesis: stimulation by poly-L-lysine. , 1999, Developmental genetics.

[33]  M. Takeichi.  Morphogenetic roles of classic cadherins. , 1995, Current opinion in cell biology.

[34]  S. J. Smith,et al.  Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion , 1996, The Journal of cell biology.

[35]  F. van Roy,et al.  Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. , 1998, Genomics.

[36]  X. Liu,et al.  N-cadherin/catenin-mediated morphoregulation of somite formation. , 1998, Developmental biology.

[37]  W. Fiers,et al.  Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role , 1991, Cell.

[38]  Albert B. Reynolds,et al.  The Catenin p120ctnInteracts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor , 1999, Molecular and Cellular Biology.

[39]  M. Hatzfeld.  The armadillo family of structural proteins. , 1999, International review of cytology.

[40]  D. Rimm,et al.  Dynamic Interaction of PTPμ with Multiple Cadherins In Vivo , 1998, The Journal of cell biology.

[41]  W J Nelson,et al.  Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay , 1996, The Journal of cell biology.

[42]  M. Ozawa.  Identification of the Region of α-Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion* , 1998, The Journal of Biological Chemistry.

[43]  M. Takeichi,et al.  Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[44]  K. Linask,et al.  N-cadherin is required for the differentiation and initial myofibrillogenesis of chick cardiomyocytes. , 1998, Cell motility and the cytoskeleton.

[45]  E. Dejana,et al.  Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. , 1999, Molecular biology of the cell.

[46]  F. Walsh,et al.  Cell adhesion molecules and neuronal regeneration. , 1996, Current opinion in cell biology.

[47]  W. Gallin.  Evolution of the "classical" cadherin family of cell adhesion molecules in vertebrates. , 1998, Molecular biology and evolution.

[48]  A. P. Soler,et al.  Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin , 1995, The Journal of cell biology.

[49]  G. Christofori,et al.  The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. , 1999, Trends in biochemical sciences.

[50]  M. Pasdar,et al.  Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin. , 1998, Cell motility and the cytoskeleton.

[51]  J. Daniel,et al.  Tyrosine phosphorylation and cadherin/catenin function , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[52]  Frits Michiels,et al.  Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase , 1998, The Journal of cell biology.

[53]  Peter D. Kwong,et al.  Structural basis of cell-cell adhesion by cadherins , 1995, Nature.

[54]  O. Kocher,et al.  H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo. , 1998, Carcinogenesis.

[55]  A. Levine,et al.  The role of beta‐catenin in cell adhesion, signal transduction, and cancer , 1998, Current opinion in oncology.

[56]  Kenneth M. Yamada,et al.  Molecular interactions in cell adhesion complexes. , 1997, Current opinion in cell biology.

[57]  E. Dejana,et al.  Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization , 1998, The Journal of cell biology.

[58]  Y. Hata,et al.  Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. , 1999, Biochemical and biophysical research communications.

[59]  O. Pertz,et al.  A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E‐cadherin homoassociation , 1999, The EMBO journal.

[60]  I. Nabi,et al.  Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules , 1995, The Journal of cell biology.

[61]  R. Kemler,et al.  The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity , 1998, The Journal of cell biology.

[62]  Yih-Tai Chen,et al.  Coupling Assembly of the E-Cadherin/β-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells , 1999, The Journal of cell biology.

[63]  M. Nieman,et al.  Cadherins Promote Skeletal Muscle Differentiation in Three-dimensional Cultures , 1997, The Journal of cell biology.

[64]  Akinao Nose,et al.  Localization of specificity determining sites in cadherin cell adhesion molecules , 1990, Cell.

[65]  G. S. Davis,et al.  Germ-layer surface tensions and "tissue affinities" in Rana pipiens gastrulae: quantitative measurements. , 1997, Developmental biology.

[66]  F. Walsh,et al.  Review: a role for the FGF receptor in the axonal growth response stimulated by cell adhesion molecules? , 1996, Cell adhesion and communication.

[67]  B. Gumbiner,et al.  Lateral dimerization is required for the homophilic binding activity of C-cadherin , 1996, The Journal of cell biology.

[68]  M. Pasdar,et al.  L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin. , 1998, Journal of cell science.

[69]  M. S. Steinberg,et al.  Adhesion in development: an historical overview. , 1996, Developmental biology.