Simvastatin inhibits Staphylococcus aureus alpha toxin mediated polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction

[1]  W. Seeger,et al.  Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus &agr;-Toxin , 2002, Circulation.

[2]  W. Seeger,et al.  Staphylococcus Aureus Alpha Toxin Mediates Polymorphonuclear Leukocyte-Induced Vasocontraction and Endothelial Dysfunction , 2002, Shock.

[3]  A. M. Lefer,et al.  A new HMG‐CoA reductase inhibitor, rosuvastatin, exerts anti‐inflammatory effects on the microvascular endothelium: the role of mevalonic acid , 2001, British journal of pharmacology.

[4]  W. Seeger,et al.  Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. , 2000, Circulation.

[5]  A. M. Lefer,et al.  Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[6]  A. M. Lefer,et al.  Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. , 1999, Circulation.

[7]  M. Moskowitz,et al.  Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  U. Laufs,et al.  Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. , 1998, Circulation.

[9]  A. Cheung,et al.  Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins , 1997, Infection and immunity.

[10]  W. Seeger,et al.  Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. , 1997, Journal of immunology.

[11]  N. Suttorp,et al.  Escherichia coli hemolysin and Staphylococcus aureas alpha-toxin potently induce neutrophil adhesion to cultured human endothelial cells. , 1996, Journal of immunology.

[12]  A. M. Lefer,et al.  Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. , 1996, Circulation research.

[13]  A. M. Lefer,et al.  Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[14]  N. Suttorp,et al.  Stimulation of PAF-synthesis in pulmonary artery endothelial cells by Staphylococcus aureus alpha-toxin. , 1992, Thrombosis research.

[15]  S Bhakdi,et al.  Alpha-toxin of Staphylococcus aureus. , 1991, Microbiological reviews.

[16]  G. Zimmerman,et al.  Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils , 1991, The Journal of cell biology.

[17]  R. McEver Leukocyte Interactions Mediated by Selectins , 1991, Thrombosis and Haemostasis.

[18]  A. M. Lefer,et al.  Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery. , 1991, Circulation research.

[19]  P. Kubes,et al.  Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Fleming,et al.  A method for isolation and fluorescent labeling of rat neutrophils for intravital microvascular studies. , 1990, Microvascular research.

[21]  J. Goldstein,et al.  Regulation of the mevalonate pathway , 1990, Nature.

[22]  E. Ohlstein,et al.  Rabbit Polymorphonuclear Neutrophils Elicit Endothelium-Dependent Contraction in Vascular Smooth Muscle , 1989, Circulation research.

[23]  S. Weiss Tissue destruction by neutrophils. , 1989, The New England journal of medicine.

[24]  S. Bhakdi,et al.  Damage to mammalian cells by proteins that form transmembrane pores. , 1987, Reviews of physiology, biochemistry and pharmacology.

[25]  P. Vanhoutte,et al.  Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. , 1986, The American journal of physiology.

[26]  R. Paul,et al.  Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP. , 1986, The American journal of physiology.

[27]  R. Furchgott Role of endothelium in responses of vascular smooth muscle. , 1983, Circulation research.

[28]  P. Ward,et al.  Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. , 1982, The American journal of pathology.

[29]  A. Bøyum,et al.  Separation of leukocytes from blood and bone marrow. Introduction. , 1968 .

[30]  A. Bøyum,et al.  Isolation of mononuclear cells and granulocytes from human blood. , 1968 .

[31]  C. Mogensen The glomerular permeability determined by dextran clearance using Sephadex gel filtration. , 1968, Scandinavian journal of clinical and laboratory investigation.