Migraine pathophysiology: lessons from mouse models and human genetics

[1]  Tammy J. Toney-Butler Cortical Spreading Depression , 2015 .

[2]  M. Ferrari,et al.  PRRT2 and hemiplegic migraine: A complex association , 2014, Neurology.

[3]  S. Tsang,et al.  Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines. , 2014, Human molecular genetics.

[4]  J. Borst,et al.  Synaptic Gain-of-Function Effects of Mutant Cav2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca2+]i , 2014, The Journal of Neuroscience.

[5]  M. Ferrari,et al.  Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: A Fos protein study , 2014, Neurobiology of Disease.

[6]  H. Diener,et al.  Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks , 2014, Cephalalgia : an international journal of headache.

[7]  R. Burstein,et al.  Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain , 2013 .

[8]  Bin Yang,et al.  Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans , 2013, Science Translational Medicine.

[9]  K. Merikangas,et al.  Episodic migraine and obesity and the influence of age, race, and sex , 2013, Neurology.

[10]  M. Ferrari,et al.  Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice , 2013, PAIN®.

[11]  E. Chronicle,et al.  Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. , 2013, The Cochrane database of systematic reviews.

[12]  Thomas Meitinger,et al.  Genome-wide meta-analysis identifies new susceptibility loci for migraine , 2013, Nature Genetics.

[13]  M. Vidailhet,et al.  PRRT2 mutations and paroxysmal disorders , 2013, European journal of neurology.

[14]  J. Olesen,et al.  Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience , 2013, Cephalalgia : an international journal of headache.

[15]  M. Ferrari,et al.  Pearls and pitfalls in genetic studies of migraine , 2013, Cephalalgia : an international journal of headache.

[16]  Christopher R. Jones,et al.  Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase , 2013, Science Translational Medicine.

[17]  Eiki Takahashi,et al.  Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice. , 2013, Biochemical and biophysical research communications.

[18]  Z. Sen,et al.  Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels , 2013, Science.

[19]  H. Kaube,et al.  A randomized controlled trial of intranasal ketamine in migraine with prolonged aura , 2013, Neurology.

[20]  J. Buring,et al.  Relative Contribution of Migraine with Aura to Cardiovascular Disease Occurrence in Women (S40.001) , 2013 .

[21]  C. A. Frank,et al.  Pharmacological Correction of Gating Defects in the Voltage-Gated Cav2.1 Ca2+ Channel due to a Familial Hemiplegic Migraine Mutation , 2013, Neuron.

[22]  M. Ferrari,et al.  TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine , 2013, PloS one.

[23]  Bernadette A. Thomas,et al.  Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[24]  E. Fabbretti,et al.  Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine , 2012, BMC Neuroscience.

[25]  R. Guerrini,et al.  PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine , 2012, Neurology.

[26]  M. Ferrari,et al.  Structural brain changes in migraine. , 2012, JAMA.

[27]  Chris I De Zeeuw,et al.  Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators in Cacna1aS218L Mutant Mice , 2012, The Journal of Neuroscience.

[28]  Thomas Meitinger,et al.  Genome-wide association analysis identifies susceptibility loci for migraine without aura , 2012, Nature Genetics.

[29]  T J Steiner,et al.  The cost of headache disorders in Europe: the Eurolight project , 2012, European journal of neurology.

[30]  Peter J. Goadsby,et al.  Chronic migraine—classification, characteristics and treatment , 2012, Nature Reviews Neurology.

[31]  T. Kurth,et al.  Migraine and stroke: a complex association with clinical implications , 2012, The Lancet Neurology.

[32]  L. Griffiths,et al.  Functional analysis of missense variants in the TRESK (KCNK18) K+ channel , 2012, Scientific Reports.

[33]  M. Moskowitz,et al.  Migraine Mutations Increase Stroke Vulnerability by Facilitating Ischemic Depolarizations , 2012, Circulation.

[34]  L. Sforna,et al.  Trigeminal ganglion neuron subtype‐specific alterations of CaV2.1 calcium current and excitability in a Cacna1a mouse model of migraine , 2011, The Journal of physiology.

[35]  J. Shendure,et al.  Exome sequencing as a tool for Mendelian disease gene discovery , 2011, Nature Reviews Genetics.

[36]  G. Rouleau,et al.  Migraine: Role of the TRESK two-pore potassium channel. , 2011, The international journal of biochemistry & cell biology.

[37]  P. Goadsby,et al.  Diencephalic and brainstem mechanisms in migraine , 2011, Nature Reviews Neuroscience.

[38]  J. Lennerz,et al.  [Neuropeptide effects on the trigeminal system: pathophysiology and clinical significance for migraine]. , 2011, Schmerz.

[39]  P. Ridker,et al.  Genetic Determinants of Cardiovascular Events among Women with Migraine: A Genome-Wide Association Study , 2011, PloS one.

[40]  Wolfgang Hoffmann,et al.  Genome-wide association study reveals three susceptibility loci for common migraine in the general population , 2011, Nature Genetics.

[41]  R. Lipton,et al.  The International Burden of Migraine Study (IBMS): Study design, methodology, and baseline cohort characteristics , 2011, Cephalalgia : an international journal of headache.

[42]  T. Pizzorusso,et al.  Increased Susceptibility to Cortical Spreading Depression in the Mouse Model of Familial Hemiplegic Migraine Type 2 , 2011, PLoS genetics.

[43]  Dan Levy,et al.  Activation of central trigeminovascular neurons by cortical spreading depression , 2011, Annals of neurology.

[44]  M. Russell,et al.  Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management , 2011, The Lancet Neurology.

[45]  A. Lentini,et al.  Sleep and primary headaches , 2011, Neurological Sciences.

[46]  Y. R. Kim,et al.  Enhanced Subcortical Spreading Depression in Familial Hemiplegic Migraine Type 1 Mutant Mice , 2011, The Journal of Neuroscience.

[47]  E. Fabbretti,et al.  Calcitonin Gene-Related Peptide-Mediated Enhancement of Purinergic Neuron/Glia Communication by the Algogenic Factor Bradykinin in Mouse Trigeminal Ganglia from Wild-Type and R192Q Cav2.1 Knock-In Mice: Implications for Basic Mechanisms of Migraine Pain , 2011, The Journal of Neuroscience.

[48]  M. Moskowitz,et al.  Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression , 2011, Annals of neurology.

[49]  J. Serra,et al.  TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury , 2011, Molecular pain.

[50]  J. Couch Amitriptyline in the Prophylactic Treatment of Migraine and Chronic Daily Headache , 2011, Headache.

[51]  B. MacVicar,et al.  Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel , 2010, Proceedings of the National Academy of Sciences.

[52]  P. Goadsby,et al.  CGRP and its receptors provide new insights into migraine pathophysiology , 2010, Nature Reviews Neurology.

[53]  Marie-Pierre Dubé,et al.  A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura , 2010, Nature Medicine.

[54]  C. Depienne,et al.  De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine , 2010, Neurology.

[55]  Andrew Escayg,et al.  Sodium channel SCN1A and epilepsy: Mutations and mechanisms , 2010, Epilepsia.

[56]  K. Mikoshiba,et al.  Defective membrane expression of the Na+-HCO3− cotransporter NBCe1 is associated with familial migraine , 2010, Proceedings of the National Academy of Sciences.

[57]  Thomas Meitinger,et al.  Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 , 2010, Nature Genetics.

[58]  L. Becerra,et al.  Thalamic sensitization transforms localized pain into widespread allodynia , 2010, Annals of neurology.

[59]  Dan Levy,et al.  Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura , 2010, The Journal of Neuroscience.

[60]  M. Hatten,et al.  Astn2, A Novel Member of the Astrotactin Gene Family, Regulates the Trafficking of ASTN1 during Glial-Guided Neuronal Migration , 2010, The Journal of Neuroscience.

[61]  M. Ferrari,et al.  Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential. , 2010, Journal of neurophysiology.

[62]  K. Craig,et al.  Coding of facial expressions of pain in the laboratory mouse , 2010, Nature Methods.

[63]  Cenk Ayata,et al.  Cortical Spreading Depression Triggers Migraine Attack: Pro , 2010, Headache.

[64]  A. Charles Does Cortical Spreading Depression Initiate a Migraine Attack? Maybe Not . . . , 2010, Headache.

[65]  R. Lipton,et al.  Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial , 2010, The Lancet Neurology.

[66]  J. Olesen,et al.  Matrix metalloproteinases during and outside of migraine attacks without aura , 2010, Cephalalgia : an international journal of headache.

[67]  N. Santanello,et al.  Migraine and cardiovascular disease , 2010, Neurology.

[68]  J. Olesen,et al.  Coexisting typical migraine in familial hemiplegic migraine , 2010, Neurology.

[69]  M. Ferrari,et al.  Shared genetic factors in migraine and depression , 2010, Neurology.

[70]  E. Benarroch Glutamate transporters , 2010, Neurology.

[71]  M. Ferrari,et al.  Familial hemiplegic migraine CaV2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain , 2010, Molecular pain.

[72]  Rob C. G. van de Ven,et al.  High cortical spreading depression susceptibility and migraine‐associated symptoms in Cav2.1 S218L mice , 2010, Annals of neurology.

[73]  P. Fisher,et al.  Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis , 2009, Proceedings of the National Academy of Sciences.

[74]  J. Olesen,et al.  The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. , 2009, Pharmacology & therapeutics.

[75]  M. Moskowitz,et al.  Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice , 2009, Annals of neurology.

[76]  M. Ferrari,et al.  Migraine and Genetic and Acquired Vasculopathies , 2009, Cephalalgia : an international journal of headache.

[77]  J. Olesen,et al.  Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study , 2009, The Lancet Neurology.

[78]  J. Olesen,et al.  Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of the Cortical Spreading Depression Inhibiting Agent Tonabersat in Migraine Prophylaxis , 2009, Cephalalgia : an international journal of headache.

[79]  M. Ferrari,et al.  Molecular genetics of migraine , 2009, Human Genetics.

[80]  B. Spiegelman,et al.  Transcriptional control of brown adipocyte development and physiological function--of mice and men. , 2009, Genes & development.

[81]  M. Hemler,et al.  Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. , 2009, Molecular biology of the cell.

[82]  M. Ferrari,et al.  Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice , 2009, Neuron.

[83]  M. Moskowitz,et al.  Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. , 2008, The Journal of clinical investigation.

[84]  M. Daly,et al.  A high-density association screen of 155 ion transport genes for involvement with common migraine. , 2008, Human molecular genetics.

[85]  J. Olesen The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. , 2008, Pharmacology & therapeutics.

[86]  Rob C. G. van de Ven,et al.  Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice , 2008, Annals of neurology.

[87]  Massimo Mantegazza,et al.  Self-Limited Hyperexcitability: Functional Effect of a Familial Hemiplegic Migraine Mutation of the Nav1.1 (SCN1A) Na+ Channel , 2008, The Journal of Neuroscience.

[88]  D. Strickland,et al.  LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. , 2008, Physiological reviews.

[89]  A. V. D. Maagdenberg,et al.  The S218L familial hemiplegic migraine mutation promotes deinhibition of Cav2.1 calcium channels during direct G-protein regulation , 2008, Pflügers Archiv - European Journal of Physiology.

[90]  E. MacGregor Menstrual migraine , 2008, Current opinion in neurology.

[91]  J. Olesen The International Classification of Headache Disorders , 2008, Headache.

[92]  U. Heinemann,et al.  Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex , 2008, Stroke.

[93]  L. Stovner,et al.  Epidemiology and comorbidity of headache , 2008, The Lancet Neurology.

[94]  M. Ferrari,et al.  Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine , 2007, Neurology.

[95]  S. Nelson,et al.  C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy , 2007, Nature Genetics.

[96]  T. Sobrino,et al.  MMP‐9 Immunoreactivity in Acute Migraine , 2007, Headache.

[97]  M. Ruonala,et al.  Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. , 2007, Molecular biology of the cell.

[98]  R. Lipton,et al.  Migraine prevalence, disease burden, and the need for preventive therapy , 2007, Neurology.

[99]  G. Terwindt,et al.  The Prevalence of Premonitory Symptoms in Migraine: A Questionnaire Study in 461 Patients , 2006, Cephalalgia : an international journal of headache.

[100]  H. Anderson,et al.  Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain , 2006, Current Biology.

[101]  M. Moskowitz,et al.  Suppression of cortical spreading depression in migraine prophylaxis , 2006, Annals of neurology.

[102]  Steven W. Flavell,et al.  Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number , 2006, Science.

[103]  P. Goadsby,et al.  Calcium channels modulate nociceptive transmission in the trigeminal nucleus of the cat , 2005, Neuroscience.

[104]  J. Haan,et al.  The 3p21.1-p21.3 Hereditary Vascular Retinopathy Locus Increases the Risk for Raynaud's Phenomenon and Migraine , 2005, Cephalalgia : an international journal of headache.

[105]  M. Ferrari,et al.  Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. , 2005, Brain : a journal of neurology.

[106]  R. Baloh,et al.  Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures , 2005, Neurology.

[107]  E. Purisima,et al.  Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[108]  T. Strom,et al.  Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine , 2005, The Lancet.

[109]  E. Bamberg,et al.  Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation. , 2005, Biochimica et biophysica acta.

[110]  T. Fellin,et al.  Specific Kinetic Alterations of Human CaV2.1 Calcium Channels Produced by Mutation S218L Causing Familial Hemiplegic Migraine and Delayed Cerebral Edema and Coma after Minor Head Trauma* , 2005, Journal of Biological Chemistry.

[111]  Ying Xu,et al.  Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome , 2005, Nature.

[112]  A. M. van den Maagdenberg,et al.  Familial Hemiplegic Migraine Type 1 Mutations K1336E, W1684R, and V1696I Alter Cav2.1 Ca2+ Channel Gating , 2004, Journal of Biological Chemistry.

[113]  H. Kaube,et al.  Glyceryl trinitrate triggers premonitory symptoms in migraineurs , 2004, Pain.

[114]  M. Ferrari,et al.  An AUPN/ANA survey of department leader opinions on the health of US academic neurology , 2004, Neurology.

[115]  Kirk W. Johnson,et al.  LY293558, a Novel AMPA/GluR5 Antagonist, is Efficacious and Well-Tolerated in Acute Migraine , 2004, Cephalalgia : an international journal of headache.

[116]  M. Dichgans,et al.  Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants , 2004, Neurology.

[117]  P. Greengard,et al.  Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[118]  K. Merikangas,et al.  Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities , 2004, Genetic epidemiology.

[119]  Simon Kaja,et al.  A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression , 2004, Neuron.

[120]  A. Strongin,et al.  The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells* , 2004, Journal of Biological Chemistry.

[121]  G. Sances,et al.  Reliability of the Nitroglycerin Provocative Test in the Diagnosis of Neurovascular Headaches , 2004, Cephalalgia : an international journal of headache.

[122]  M. Ferrari,et al.  Migraine as a risk factor for subclinical brain lesions. , 2004, JAMA.

[123]  J. Olesen,et al.  The International Classification of Headache Disorders: 2nd edition , 2003, The Lancet Neurology.

[124]  A. Ballabio,et al.  Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2 , 2003, Nature Genetics.

[125]  G. Seabrook,et al.  The familial hemiplegic migraine mutation R192q reduces G‐protein‐mediated inhibition of p/q‐type (Cav2.1) calcium channels expressed in human embryonic kidney cells , 2003, The Journal of physiology.

[126]  M. Dichgans Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Phenotypic and mutational spectrum , 2002, Journal of the Neurological Sciences.

[127]  W. Rascher,et al.  Glutaric aciduria type III: A distinctive non-disease? , 2002, Journal of Inherited Metabolic Disease.

[128]  C. Fletcher,et al.  Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[129]  J. Olesen,et al.  Migraine Without Aura and Migraine With Aura Are Distinct Disorders. A Population‐Based Twin Survey , 2002, Headache.

[130]  T. Bartsch,et al.  P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine? , 2002, The Journal of Neuroscience.

[131]  Andrew K. Dunn,et al.  Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model , 2002, Nature Medicine.

[132]  R. Lipton,et al.  Migraine--current understanding and treatment. , 2002, The New England journal of medicine.

[133]  Ferrari,et al.  Drug therapy: Migraine - Current understanding and treatment. , 2002 .

[134]  A. Palotie,et al.  Familial migraine with and without aura: clinical characteristics and co‐occurrence , 2001, European journal of neurology.

[135]  R. Lipton,et al.  Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II , 2001, Headache.

[136]  E. Vicaut,et al.  The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. , 2001, The New England journal of medicine.

[137]  S. Love,et al.  Delayed cerebral edema and fatal coma after minor head trauma: Role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine , 2001, Annals of neurology.

[138]  J. Schoenen,et al.  Subclinical cerebellar impairment in the common types of migraine: A three‐dimensional analysis of reaching movements , 2001, Annals of neurology.

[139]  B. Rosen,et al.  Mechanisms of migraine aura revealed by functional MRI in human visual cortex , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[140]  P. Sassone-Corsi,et al.  A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM , 2000, Molecular and Cellular Biology.

[141]  M. Ferrari,et al.  The impact of migraine on quality of life in the general population , 2000, Neurology.

[142]  J. Olesen,et al.  Nitric oxide-induced headache in patients with chronic tension-type headache. , 2000, Brain : a journal of neurology.

[143]  M. Moskowitz,et al.  Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels , 1999, Neuroscience.

[144]  J. Olesen,et al.  Glyceryl Trinitrate Induces Attacks of Migraine Without Aura in Sufferers of Migraine with Aura , 1999, Cephalalgia : an international journal of headache.

[145]  Lenore J. Launer,et al.  The prevalence and characteristics of migraine in a population-based cohort , 1999, Neurology.

[146]  Kazuto Yamazaki,et al.  Single Tottering Mutations Responsible for the Neuropathic Phenotype of the P-type Calcium Channel* , 1998, The Journal of Biological Chemistry.

[147]  R. Ophoff,et al.  Clinical and genetic analysis of a large Dutch family with autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon. , 1998, Brain : a journal of neurology.

[148]  Richard Hawkes,et al.  Absence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects , 1996, Cell.

[149]  Dennis E Bulman,et al.  Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4 , 1996, Cell.

[150]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[151]  B. Dubois,et al.  Clinical spectrum of CADASIL: a study of 7 families , 1995, The Lancet.

[152]  M. Russell,et al.  Increased familial risk and evidence of genetic factor in migraine , 1995, BMJ.

[153]  J. Mazziotta,et al.  Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. , 1994, The New England journal of medicine.

[154]  Bruce L. Ehrenberg,et al.  Comorbidity of migraine: The connection between migraine and epilepsy , 1994, Neurology.

[155]  J. Olesen,et al.  A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks , 1994, European journal of neurology.

[156]  M. Lauritzen,et al.  Pathophysiology of the migraine aura. The spreading depression theory. , 1994, Brain : a journal of neurology.

[157]  C. Tzourio,et al.  Migraine and risk of ischaemic stroke: a case-control study. , 1993, BMJ.

[158]  R. Weinberg,et al.  Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase , 1992, Cell.

[159]  T. Olsen,et al.  Timing and topography of cerebral blood flow, aura, and headache during migraine attacks , 1990, Annals of neurology.

[160]  M. Ferrari,et al.  Serotonin metabolism in migraine , 1989, Neurology.

[161]  S. Silberstein,et al.  Migraine , 1934, The Lancet.

[162]  A. Hofman,et al.  Genome-wide association study of migraine implicates a common susceptibility variant on 8 q 22 . 1 , 2010 .

[163]  N. Fernàndez-Castillo,et al.  The hemiplegic migraine-associated Y 1245 C mutation in CACNA 1 A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition , 2009 .

[164]  William B. Dobyns,et al.  Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel , 1997, Nature Genetics.

[165]  Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. , 1992, Cell.