Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells.

[1]  L. Galluzzi,et al.  Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos , 2010, The EMBO journal.

[2]  Jean M. Davidson,et al.  Endoreplication: polyploidy with purpose. , 2009, Genes & development.

[3]  H. Okazawa,et al.  Neural stem cells express Oct-3/4. , 2009, Biochemical and biophysical research communications.

[4]  A. Składanowski,et al.  Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models , 2009, Cell cycle.

[5]  H. Scherthan,et al.  The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. , 2009, Experimental cell research.

[6]  Ge Guo,et al.  Nanog Is the Gateway to the Pluripotent Ground State , 2009, Cell.

[7]  Jeffrey M. Rosen,et al.  Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features , 2009, Proceedings of the National Academy of Sciences.

[8]  Y. Toiyama,et al.  Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy , 2009, Annals of Surgical Oncology.

[9]  Kristopher L. Nazor,et al.  Adult mice generated from induced pluripotent stem cells , 2009, Nature.

[10]  W. Reik,et al.  Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal , 2009, Nature Reviews Molecular Cell Biology.

[11]  Bin Wang,et al.  Alternative Translation of OCT4 by an Internal Ribosome Entry Site and its Novel Function in Stress Response , 2009, Stem cells.

[12]  G. Ruvkun,et al.  A soma-to-germline transformation in long-lived C. elegans mutants , 2009, Nature.

[13]  T. Agorastos,et al.  OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness. , 2009, Molecular human reproduction.

[14]  Geert Verbeke,et al.  Chromosome instability is common in human cleavage-stage embryos , 2009, Nature Medicine.

[15]  M. Kalējs,et al.  Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe. , 2009, Cancer research.

[16]  C. Jordan.  Cancer stem cells: controversial or just misunderstood? , 2009, Cell stem cell.

[17]  M. Stojkovic,et al.  A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A , 2009, The Journal of cell biology.

[18]  P. Andrews,et al.  OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells , 2008, Stem cells.

[19]  N. Mizuno,et al.  Novel Variants of Oct-3/4 Gene Expressed in Mouse Somatic Cells* , 2008, Journal of Biological Chemistry.

[20]  K. Mimori,et al.  Cancer stem cells and chemoradiation resistance , 2008, Cancer science.

[21]  B. Chauffert,et al.  Tumor cells can escape DNA‐damaging cisplatin through DNA endoreduplication and reversible polyploidy , 2008, Cell biology international.

[22]  P. Davis,et al.  Endopolyploidy in irradiated p53‐deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora‐B kinase , 2008, Cell biology international.

[23]  G. Kögler,et al.  Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research , 2008, Biological chemistry.

[24]  B. Zhivotovsky,et al.  Death through a tragedy: mitotic catastrophe , 2008, Cell Death and Differentiation.

[25]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[26]  Eran Segal,et al.  Module map of stem cell genes guides creation of epithelial cancer stem cells. , 2008, Cell stem cell.

[27]  A. Rizzino,et al.  Small Increases in the Level of Sox2 Trigger the Differentiation of Mouse Embryonic Stem Cells , 2008, Stem cells.

[28]  C. Lengner,et al.  The pluripotency regulator Oct4: A role in somatic stem cells? , 2008, Cell cycle.

[29]  Michael O. Dorschner,et al.  Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. , 2008, Genes & development.

[30]  H. Schöler,et al.  Absence of OCT4 Expression in Somatic Tumor Cell Lines , 2008, Stem cells.

[31]  P. Pontarotti.  Evolutionary Biology from Concept to Application , 2008 .

[32]  M. Cragg,et al.  Life-Cycle Features of Tumour Cells , 2008 .

[33]  F. Mertens,et al.  The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. , 2008, Oncology reports.

[34]  J. Nichols,et al.  Nanog safeguards pluripotency and mediates germline development , 2007, Nature.

[35]  M. Cragg,et al.  Cancer: A matter of life cycle? , 2007, Cell biology international.

[36]  M. Blagosklonny.  Cancer stem cell and cancer stemloids: From biology to therapy , 2007, Cancer biology & therapy.

[37]  C. Lengner,et al.  Oct4 expression is not required for mouse somatic stem cell self-renewal. , 2007, Cell stem cell.

[38]  H. Schöler,et al.  Sumoylation of Oct4 Enhances Its Stability, DNA Binding, and Transactivation* , 2007, Journal of Biological Chemistry.

[39]  T. Ichisaka,et al.  Generation of germline-competent induced pluripotent stem cells , 2007, Nature.

[40]  G. Pan,et al.  A Dominant-negative Form of Mouse SOX2 Induces Trophectoderm Differentiation and Progressive Polyploidy in Mouse Embryonic Stem Cells* , 2007, Journal of Biological Chemistry.

[41]  A. Peaston,et al.  Genome plasticity in the mouse oocyte and early embryo. , 2007, Biochemical Society transactions.

[42]  H. Broxmeyer,et al.  Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. , 2007, Blood.

[43]  R. DePinho,et al.  Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence , 2007, Aging cell.

[44]  Techung Lee,et al.  Stem cell regulatory function mediated by expression of a novel mouse Oct4 pseudogene. , 2007, Biochemical and biophysical research communications.

[45]  Ying Liu,et al.  Qualification of Embryonal Carcinoma 2102Ep As a Reference for Human Embryonic Stem Cell Research , 2007, Stem cells.

[46]  B. Lim,et al.  The molecular basis of ageing in stem cells , 2007, Mechanisms of Ageing and Development.

[47]  A. V. Van Steirteghem,et al.  POU5F1 Isoforms Show Different Expression Patterns in Human Embryonic Stem Cells and Preimplantation Embryos , 2006, Stem cells.

[48]  K. Ligon,et al.  Comparative Analysis of Germ Cell Transcription Factors in CNS Germinoma Reveals Diagnostic Utility of NANOG , 2006, The American journal of surgical pathology.

[49]  D. Guernsey,et al.  Stem cells, senescence, neosis and self-renewal in cancer , 2006, Cancer Cell International.

[50]  Jungho Kim,et al.  The Human OCT-4 Isoforms Differ in Their Ability to Confer Self-renewal* , 2006, Journal of Biological Chemistry.

[51]  M. Noble,et al.  Cancer stem cells. , 2006, The New England journal of medicine.

[52]  Jin Han,et al.  NANOGP8 is a retrogene expressed in cancers , 2006, The FEBS journal.

[53]  M. Kalējs,et al.  Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe , 2006, BMC Cancer.

[54]  Jin Han,et al.  Oct4 pseudogenes are transcribed in cancers. , 2005, Biochemical and biophysical research communications.

[55]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[56]  P. Robson,et al.  Transcriptional Regulation of Nanog by OCT4 and SOX2* , 2005, Journal of Biological Chemistry.

[57]  Szu-Yu Chen,et al.  Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. , 2005, Cancer research.

[58]  Ettore Appella,et al.  p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression , 2005, Nature Cell Biology.

[59]  Austin G Smith,et al.  Self-renewal of teratocarcinoma and embryonic stem cells , 2004, Oncogene.

[60]  Graham Dellaire,et al.  PML nuclear bodies: dynamic sensors of DNA damage and cellular stress , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.

[61]  P. Holland,et al.  Eleven daughters of NANOG. , 2004, Genomics.

[62]  Masaru Tomita,et al.  A new role for expressed pseudogenes as ncRNA: regulation of mRNA stability of its homologous coding gene , 2004, Journal of Molecular Medicine.

[63]  A. Hart,et al.  Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[64]  J. Shay,et al.  Hallmarks of senescence in carcinogenesis and cancer therapy , 2004, Oncogene.

[65]  D. Guernsey,et al.  Neosis: A Novel Type of Cell Division in Cancer , 2004, Cancer biology & therapy.

[66]  T. Illidge,et al.  Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks , 2003, Journal of Cell Science.

[67]  Masashi Narita,et al.  Reversal of human cellular senescence: roles of the p53 and p16 pathways , 2003, The EMBO journal.

[68]  T. Illidge,et al.  POLYPLOID GIANT CELLS PROVIDE A SURVIVAL MECHANISM FOR p53 MUTANT CELLS AFTER DNA DAMAGE , 2000, Cell biology international.

[69]  S Rozen,et al.  Primer3 on the WWW for general users and for biologist programmers. , 2000, Methods in molecular biology.

[70]  T. Jacks,et al.  Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption , 1998, Molecular and Cellular Biology.

[71]  H. Schöler,et al.  Retinoic acid‐mediated down‐regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. , 1996, The EMBO journal.

[72]  S. Walter,et al.  The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status. , 1995, Mutation research.

[73]  J. Bond,et al.  Escape from senescence in human diploid fibroblasts induced directly by mutant p53. , 1994, Oncogene.

[74]  A. V. van Puijenbroek,et al.  Characterization of a negative retinoic acid response element in the murine Oct4 promoter , 1994, Molecular and cellular biology.

[75]  K. Kohn,et al.  Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. , 1993, Cancer research.

[76]  P. Malet,et al.  Assessment of polyploidy in human morulae and blastocysts using co-culture and fluorescent in-situ hybridization. , 1993, Human reproduction.