Relationships between age, drugs, oral sensorial complaints and salivary profile.

The aim of this study was to investigate the relationships between oral sensorial complaints (OSCs) and salivary flow rate, composition and drug consumption of subjects aged 18-90 years. The results were correlated with both drug consumption and OSCs. Only individuals who were free of conditions that are already known to cause OSCs were included in the study. The three most significant observations were as follows: (1) elderly people have significantly reduced and altered salivary secretion compared with younger people. While specific concentrations increased, the total values of most salivary components decreased in the elderly; (2) 50% of the elderly population have OSCs regarding taste, burning mouth syndrome or xerostomia; and (3) OSCs were more prevalent in elderly people who use drugs than in those who do not. In conclusion, a reduction in salivary function and altered composition are age related. A compensatory capacity that prevents OSCs appears to exist in elderly patients who do not use drugs, but drugs were found to have an extensive effect on OSCs. The finding that the total amounts of salivary components and not only the salivary flow rate were reduced in elderly people is of great clinical relevance, since such a reduction is expected to be reflected in compromising various salivary functions.

[1]  J D Rugh,et al.  Association of Salivary Flow Rates with Maximal Bite Force , 2000, Journal of dental research.

[2]  R. Szargel,et al.  Clinical Science Whole-saliva Secretion Rates in Old and Young Healthy Subjects , 1984 .

[3]  M. Hofman,et al.  Alterations in the circadian rhythm of salivary melatonin begin during middle‐age , 2003, Journal of pineal research.

[4]  D. Laufer,et al.  The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects. , 1986, Biochemical medicine and metabolic biology.

[5]  A. Nagler,et al.  Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study , 1999, Bone Marrow Transplantation.

[6]  J. Scott.  Degenerative changes in the histology of the human submandibular salivary gland occurring with age. , 1977, Journal de biologie buccale.

[7]  H. Kho,et al.  Analysis of residual saliva and minor salivary gland secretions in patients with dry mouth. , 2002, Archives of oral biology.

[8]  Y. Marmary,et al.  Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper. , 1997, Radiation research.

[9]  T. Osaki,et al.  Influence of aging on candidal growth and adhesion regulatory agents in saliva. , 2001, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[10]  A. Nagler,et al.  Major salivary gland dysfunction in human acute and chronic graft-versus-host disease (GVHD). , 1996, Bone marrow transplantation.

[11]  A. Vissink,et al.  Aging and saliva: a review of the literature. , 1996, Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry.

[12]  P. Costa,et al.  Sodium handling by aging human parotid glands is inconsistent with a two-stage secretion model. , 1984, The American journal of physiology.

[13]  J. Johnson,et al.  Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. , 1993, The New England journal of medicine.

[14]  P. Marsh,et al.  Flow Rates of Resting Whole and Stimulated Parotid Saliva in Relation to Age and Gender , 1994, Journal of dental research.

[15]  R. Nagler,et al.  Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress. , 2003, Rheumatology.

[16]  C. Tylenda,et al.  Evaluation of Submandibular Salivary Flow Rate in Different Age Groups , 1988, Journal of dental research.

[17]  B. J. Baum,et al.  Clinical Science , 1981 .

[18]  D. Gutman,et al.  The influence of age on salivary content and rate of flow. , 1974, International journal of oral surgery.

[19]  R. Nagler,et al.  New insights into salivary lactate dehydrogenase of human subjects. , 2001, The Journal of laboratory and clinical medicine.

[20]  J. Scott,et al.  A quantitative study of histological changes in the human parotid gland occurring with adult age. , 1987, Journal of oral pathology.

[21]  R. Nagler,et al.  Characterization of the differentiated antioxidant profile of human saliva. , 2002, Free radical biology & medicine.

[22]  E. Truelove,et al.  Clinical Science Age-dependent Decreases in Human Submandibular Gland Flow Rates as Measured Under Resting and Post-stimulation Conditions , 1985, Journal of dental research.

[23]  J. Ship,et al.  The relationship between dehydration and parotid salivary gland function in young and older healthy adults. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  J. Hanlon,et al.  Use of medications by persons 65 and over: data from the established populations for epidemiologic studies of the elderly. , 1992, Journal of gerontology.

[25]  A. Vissink,et al.  [Changes in secretion and composition of saliva with aging]. , 1997, Nederlands tijdschrift voor tandheelkunde.

[26]  R A Watts.  Passing the baton. , 2003, Rheumatology.

[27]  A. Wu,et al.  Extended stimulated parotid and submandibular secretion in a healthy young and old population. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  T. Parvinen,et al.  Age Dependency of Stimulated Salivary Flow Rate, pH, and Lactobacillus and Yeast Concentrations , 1982, Journal of dental research.

[29]  C. Streckfus,et al.  Aging and Salivary Cytokine Concentrations as Predictors of Whole Saliva Flow Rates among Women , 2002, Gerontology.

[30]  P. Fox,et al.  Influence of age on the secretory rates of the human minor salivary glands and whole saliva. , 1993, Archives of oral biology.

[31]  D. Shugars,et al.  Salivary Concentration of Secretory Leukocyte Protease Inhibitor, an Antimicrobial Protein, Is Decreased with Advanced Age , 2001, Gerontology.

[32]  H. Chauncey,et al.  Longitudinal Age-related Changes in Human Parotid Saliva Composition , 1987, Journal of dental research.

[33]  B. Baum,et al.  Exocrine protein secretion from human parotid glands during aging: stable release of the acidic proline-rich proteins. , 1982, Journal of gerontology.

[34]  R. Nagler,et al.  Sialochemical and gustatory analysis in patients with oral sensory complaints. , 2004, The journal of pain : official journal of the American Pain Society.

[35]  M. Navazesh,et al.  Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults , 1992, Journal of dental research.

[36]  R. Szargel,et al.  Xerostomia in the elderly: prevalence, diagnosis, complications and treatment. , 1985, Gerodontology.

[37]  J. Heremans,et al.  Immunochemical quantitation of antigens by single radial immunodiffusion. , 1965, Immunochemistry.

[38]  S. Pillemer,et al.  Xerostomia and the Geriatric Patient , 2002, Journal of the American Geriatrics Society.

[39]  M. Fisher,et al.  Composition of whole unstimulated saliva of healthy children: changes with age. , 1990, Archives of oral biology.

[40]  C. Streckfus,et al.  Comparison of stimulated parotid salivary gland flow rates in normotensive and hypertensive persons. , 1994, Oral surgery, oral medicine, and oral pathology.

[41]  R. Nagler,et al.  Saliva Analysis in the Clinical Setting: Revisiting an Underused Diagnostic Tool , 2002, Journal of Investigative Medicine.

[42]  A. Vissink,et al.  The causes and consequences of hyposalivation. , 1988, Ear, nose, & throat journal.

[43]  A. Wu,et al.  Cross-sectional and longitudinal analyses of stimulated parotid salivary constituents in healthy, different-aged subjects. , 1993, Journal of gerontology.

[44]  D. Birkhed,et al.  Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex. , 1983, Swedish dental journal.

[45]  R. Sulkava,et al.  Salivary albumin and other constituents and their relation to oral and general health in the elderly. , 2002, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.