Amygdala damage impairs emotional memory for gist but not details of complex stimuli

Neurobiological studies demonstrate the amygdala's role in emotional memory, and psychological studies suggest a particular pattern: enhanced memory for the gist but not the details of complex stimuli. We hypothesized that these two findings are related. Whereas normal (n = 52) and brain-damaged (n = 22) controls showed the expected enhancement of gist memory when the encoding context was emotional, persons with unilateral damage to the medial temporal lobe including the amygdala (n = 16) did not show this pattern. Furthermore, amygdala volume showed a significant positive correlation with gist memory but not with overall memory. A further study in four subjects with selective medial temporal damage sparing the amygdala, and one with selective damage confined to the amygdala, confirmed the specificity of this effect to the amygdala. The data support a model whereby the amygdala focuses processing resources on gist, possibly accounting for features of traumatic memories and eyewitness testimony in real life.

[1]  Hanna Damasio,et al.  Correlations between Regional Brain Volumes and Memory Performance in Anoxia , 2006, Journal of clinical and experimental neuropsychology.

[2]  N. Alpert,et al.  A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. , 1996, Archives of general psychiatry.

[3]  Dennis D. Spencer,et al.  Memory for Emotional Words Following Unilateral Temporal Lobectomy , 1997, Brain and Cognition.

[4]  J. Gerring.  A case study , 2011, Technology and Society.

[5]  J. D. McGaugh.  The amygdala modulates the consolidation of memories of emotionally arousing experiences. , 2004, Annual review of neuroscience.

[6]  R. Adolphs,et al.  The amygdala's role in long-term declarative memory for gist and detail. , 2001, Behavioral neuroscience.

[7]  John D E Gabrieli,et al.  Sex differences in the neural basis of emotional memories , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Dolan,et al.  Encoding of emotional memories depends on amygdala and hippocampus and their interactions , 2004, Nature Neuroscience.

[9]  Amanda Parker,et al.  The von Restorff Effect in Visual Object Recognition Memory in Humans and Monkeys: The Role of Frontal/Perirhinal Interaction , 1998, Journal of Cognitive Neuroscience.

[10]  R. Adolphs,et al.  Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans , 1995, Science.

[11]  R. Malpass,et al.  EYEWITNESS IDENTIFICATION , 2005 .

[12]  R. Adolphs,et al.  Impaired declarative memory for emotional material following bilateral amygdala damage in humans. , 1997, Learning & memory.

[13]  G. Richter-Levin,et al.  Biphasic Modulation of Hippocampal Plasticity by Behavioral Stress and Basolateral Amygdala Stimulation in the Rat , 1999, The Journal of Neuroscience.

[14]  A. David,et al.  Emotional memory and perception in temporal lobectomy patients with amygdala damage , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[15]  James L. McGaugh,et al.  Mechanisms of emotional arousal and lasting declarative memory , 1998, Trends in Neurosciences.

[16]  R. J. Frank,et al.  Brainvox: An Interactive, Multimodal Visualization and Analysis System for Neuroanatomical Imaging , 1997, NeuroImage.

[17]  Michael S Fanselow,et al.  Role of the Basolateral Amygdala in the Storage of Fear Memories across the Adult Lifetime of Rats , 2004, The Journal of Neuroscience.

[18]  J. Easterbrook.  The effect of emotion on cue utilization and the organization of behavior. , 1959, Psychological review.

[19]  R. Dolan,et al.  Dissociable Temporal Lobe Activations during Emotional Episodic Memory Retrieval , 2000, NeuroImage.

[20]  A. Maass,et al.  Eyewitness identification: Simulating the “Weapon effect” , 1989 .

[21]  Daniel Reisberg,et al.  Remembering emotional events , 1992, Memory & cognition.

[22]  S. Corkin,et al.  Two routes to emotional memory: distinct neural processes for valence and arousal. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. Cabeza,et al.  Interaction between the Amygdala and the Medial Temporal Lobe Memory System Predicts Better Memory for Emotional Events , 2004, Neuron.

[24]  Michael Davis,et al.  The amygdala , 2000, Current Biology.

[25]  E. Phelps,et al.  Arousal-Mediated Memory Consolidation: Role of the Medial Temporal Lobe in Humans , 1998 .

[26]  M. Packard,et al.  The basolateral amygdala is a cofactor in memory enhancement produced by intrahippocampal glutamate injections , 1999, Psychobiology.

[27]  Y. Ikegaya,et al.  The Basomedial and Basolateral Amygdaloid Nuclei Contribute to the Induction of Long‐term Potentiation in the Dentate Gyrus In Vivo , 1996, The European journal of neuroscience.

[28]  Michael D. Rugg,et al.  Event-Related Potential Correlates of the Retrieval of Emotional and Nonemotional Context , 2004, Journal of Cognitive Neuroscience.

[29]  Steven G. Potkin,et al.  Sex-Related Difference in Amygdala Activity during Emotionally Influenced Memory Storage , 2001, Neurobiology of Learning and Memory.

[30]  J. Gabrieli,et al.  Event-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience , 2000, The Journal of Neuroscience.

[31]  H. Merckelbach,et al.  Memory for Threat-relevant and Threat-irrelevant Cues in Spider Phobics , 1998 .

[32]  John Patrick Aggleton,et al.  The Amygdala : a functional analysis , 2000 .

[33]  J. D. McGaugh,et al.  A Novel Demonstration of Enhanced Memory Associated with Emotional Arousal , 1995, Consciousness and Cognition.

[34]  Elizabeth F. Loftus,et al.  Remembering emotional events: the fate of detailed information , 1991 .

[35]  L. Cahill,et al.  Sex-related impairment of memory for emotional events with β-adrenergic blockade , 2003, Neurobiology of Learning and Memory.

[36]  Ulric Neisser,et al.  Affect and Accuracy in Recall. Studies of « flashbulb » memories , 1992 .

[37]  E. Mori,et al.  Amygdalar volume and emotional memory in Alzheimer's disease. , 1999, The American journal of psychiatry.

[38]  L. Cahill,et al.  Sex-related impairment of memory for emotional events with beta-adrenergic blockade. , 2003, Neurobiology of learning and memory.

[39]  Scott T. Grafton,et al.  Amygdala activity related to enhanced memory for pleasant and aversive stimuli , 1999, Nature Neuroscience.

[40]  L. Squire,et al.  Emotional perception and memory in amnesia. , 1997, Neuropsychology.