Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy

[1]  I. Tyrlíková,et al.  No prevention or cure of epilepsy as yet , 2020, Neuropharmacology.

[2]  W. Löscher.  The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments , 2020, Neuropharmacology.

[3]  J. Engel,et al.  Biomarkers for epileptogenesis and its treatment , 2020, Neuropharmacology.

[4]  V. Santhakumar,et al.  Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable AMPA Receptor Currents and Drives Post‐Traumatic Epileptogenesis , 2020, Annals of neurology.

[5]  Stefan J. Haunsberger,et al.  A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy , 2019, Proceedings of the National Academy of Sciences.

[6]  D. Henshall,et al.  Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus , 2020, Frontiers in Neuroscience.

[7]  A. Toga,et al.  Imaging biomarkers of posttraumatic epileptogenesis , 2019, Epilepsia.

[8]  J. Kjems,et al.  Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression , 2019, Brain Stimulation.

[9]  J. Ávila,et al.  Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer’s disease , 2019, Scientific Reports.

[10]  J. Mellers,et al.  Edinburgh Research Explorer Characteristics of 698 patients with dissociative seizures: A UK multicenter study , 2022 .

[11]  P. Nachev,et al.  Progressive Cortical Thinning in Patients With Focal Epilepsy. , 2019, JAMA neurology.

[12]  S. Benbadis,et al.  The Role of EEG in the Erroneous Diagnosis of Epilepsy. , 2019, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[13]  Meriem Bensalem-Owen,et al.  Artifacts That Can Be Misinterpreted as Interictal Discharges. , 2019, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[14]  A. Vezzani,et al.  Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy , 2019, Nature Reviews Neurology.

[15]  Donncha F. O’Brien,et al.  Elevation in plasma tRNA fragments precede seizures in human epilepsy. , 2019, The Journal of clinical investigation.

[16]  D. Janigro,et al.  Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy , 2019, Neurobiology of Disease.

[17]  U. Heinemann,et al.  Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction , 2019, Epilepsia.

[18]  Thomas C. Wiegers,et al.  The Comparative Toxicogenomics Database: update 2019 , 2018, Nucleic Acids Res..

[19]  D. Galasko,et al.  Validation of MicroRNA Biomarkers for Alzheimer's Disease in Human Cerebrospinal Fluid. , 2019, Journal of Alzheimer's disease : JAD.

[20]  G. Boylan,et al.  RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns , 2018, PloS one.

[21]  H. Hamer,et al.  Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy , 2018, EBioMedicine.

[22]  R. Deichmann,et al.  Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy , 2018, Brain : a journal of neurology.

[23]  Iekhsan Othman,et al.  HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction , 2018, Front. Neurosci..

[24]  John S Duncan,et al.  Neuroimaging in epilepsy. , 2018, Current opinion in neurology.

[25]  Alexander M. Benison,et al.  Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. , 2018, Journal of neurophysiology.

[26]  A. Quattrone,et al.  Exosome‐associated miRNA profile as a prognostic tool for therapy response monitoring in multiple sclerosis patients , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  A. Becker,et al.  Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis , 2018, Neuropathology and applied neurobiology.

[28]  Igor Jurisica,et al.  mirDIP 4.1—integrative database of human microRNA target predictions , 2017, Nucleic Acids Res..

[29]  Artemis G. Hatzigeorgiou,et al.  DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions , 2017, Nucleic Acids Res..

[30]  Hsien-Da Huang,et al.  miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions , 2017, Nucleic Acids Res..

[31]  A. Vezzani,et al.  High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy , 2017, Brain, Behavior, and Immunity.

[32]  Henning Hermjakob,et al.  The Reactome pathway knowledgebase , 2013, Nucleic Acids Res..

[33]  J. D. Mills,et al.  Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs , 2017, Epilepsia.

[34]  Donncha F. O’Brien,et al.  Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus , 2017, Scientific Reports.

[35]  D. Offen,et al.  Toll‐like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE‐induced epilepsy in mice , 2017, Epilepsia.

[36]  M. Reuber,et al.  Non-epileptic attack disorder: the importance of diagnosis and treatment , 2017, BMJ Case Reports.

[37]  Yi-wu Shi,et al.  Epilepsy-associated genes , 2017, Seizure.

[38]  F. Rosenow,et al.  Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy , 2016, Molecular therapy. Nucleic acids.

[39]  Christophe Bernard,et al.  WONOEP appraisal: Molecular and cellular biomarkers for epilepsy , 2016, Epilepsia.

[40]  R. Voskuyl,et al.  Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus , 2016, Scientific Data.

[41]  A. El-Osta,et al.  Etiology matters – Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy , 2016, Scientific Reports.

[42]  T. Baram,et al.  Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. , 2016, Cell reports.

[43]  A. Keller,et al.  Distribution of miRNA expression across human tissues , 2016, Nucleic acids research.

[44]  Guangchuang Yu,et al.  ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. , 2016, Molecular bioSystems.

[45]  Henning Hermjakob,et al.  The Reactome pathway Knowledgebase , 2015, Nucleic acids research.

[46]  E. Hovig,et al.  A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome. , 2015, Annual review of genetics.

[47]  D. Henshall,et al.  Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice , 2015, Epilepsy & Behavior.

[48]  E. Aronica,et al.  Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis , 2015, Epilepsy & Behavior.

[49]  N. Rensing,et al.  Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex , 2015, Epilepsia.

[50]  N. Fejerman,et al.  Management of epilepsy in resource-limited settings. , 2015, Epileptic disorders : international epilepsy journal with videotape.

[51]  W. Löscher,et al.  Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice , 2015, Neuropharmacology.

[52]  Raphael Gottardo,et al.  Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.

[53]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[54]  J. DeFelipe,et al.  Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus , 2014, Brain Structure and Function.

[55]  Roland Eils,et al.  circlize implements and enhances circular visualization in R , 2014, Bioinform..

[56]  A. Obenaus,et al.  A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential , 2014, The Journal of Neuroscience.

[57]  Clay B Marsh,et al.  Methodological challenges in utilizing miRNAs as circulating biomarkers , 2014, Journal of cellular and molecular medicine.

[58]  E. Aronica,et al.  Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy , 2014, Neurobiology of Disease.

[59]  E. Aronica,et al.  Fetal brain mTOR signaling activation in tuberous sclerosis complex. , 2014, Cerebral cortex.

[60]  Joshua L Plotkin,et al.  MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice , 2013, Science.

[61]  K. Dębski,et al.  Alterations in miRNA Levels in the Dentate Gyrus in Epileptic Rats , 2013, PloS one.

[62]  Donncha F. O’Brien,et al.  CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures. , 2013, Brain : a journal of neurology.

[63]  B. Porter,et al.  Changes in MicroRNA Expression in the Whole Hippocampus and Hippocampal Synaptoneurosome Fraction following Pilocarpine Induced Status Epilepticus , 2013, PloS one.

[64]  P. Coubes,et al.  IgG Leakage May Contribute to Neuronal Dysfunction in Drug-Refractory Epilepsies With Blood-Brain Barrier Disruption , 2012, Journal of neuropathology and experimental neurology.

[65]  David J. Galas,et al.  Comparing the MicroRNA Spectrum between Serum and Plasma , 2012, PloS one.

[66]  Donncha F. O’Brien,et al.  Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects , 2012, Nature Medicine.

[67]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[68]  R. Stallings,et al.  miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. , 2011, The American journal of pathology.

[69]  Xavier Robin,et al.  pROC: an open-source package for R and S+ to analyze and compare ROC curves , 2011, BMC Bioinformatics.

[70]  Xiating Zhang,et al.  Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: A case–control study , 2010, Neuroscience Letters.

[71]  C. D. Fowler,et al.  Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction , 2010, The Journal of experimental medicine.

[72]  R. S. Sloviter,et al.  Classic hippocampal sclerosis and hippocampal‐onset epilepsy produced by a single “cryptic” episode of focal hippocampal excitation in awake rats , 2010, The Journal of comparative neurology.

[73]  S. Berkovic,et al.  The Epilepsy Genetic Association Database (epiGAD): Analysis of 165 genetic association studies, 1996–2008 , 2010, Epilepsia.

[74]  Heidi Dvinge,et al.  HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R , 2009, Bioinform..

[75]  R. S. Sloviter,et al.  Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation‐induced status epilepticus in the mouse , 2009, The Journal of comparative neurology.

[76]  David C. Henshall,et al.  Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice , 2008, Brain Research.

[77]  Y. Benjamini,et al.  On the Adaptive Control of the False Discovery Rate in Multiple Testing With Independent Statistics , 2000 .

[78]  W. Löscher,et al.  Intravenous Carbamazepine: Comparison of Different Parenteral Formulations in a Mouse Model of Convulsive Status Epilepticus , 1997, Epilepsia.

[79]  Z. Bortolotto,et al.  Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy , 1989, Synapse.

[80]  HighWire Press.  The journal of neuroscience : the official journal of the Society for Neuroscience. , 1981 .

[81]  J. H. Globus,et al.  JOURNAL of NEUROPATHOLOGY and EXPERIMENTAL NEUROLOGY , 1969 .

[82]  H. Steinmann.  [Surgical treatment of epilepsy]. , 1962, Die Medizinische Welt.

[83]  C. W. Greene.  THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. , 1917, Science.