Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
暂无分享,去创建一个
[1] Dongke Wu,et al. Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease. , 2015, International Journal of Clinical and Experimental Medicine.
[2] J. Talboom,et al. The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease , 2015, npj Aging and Mechanisms of Disease.
[3] A. Messina,et al. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease , 2015, The Journal of Neuroscience.
[4] A. Richardson,et al. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story , 2015, Experimental Gerontology.
[5] A. Dillin,et al. The role of protein clearance mechanisms in organismal ageing and age-related diseases , 2014, Nature Communications.
[6] A. Messina,et al. Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature , 2014, The Journal of Neuroscience.
[7] A. Schürmann,et al. Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle , 2014, Archives of physiology and biochemistry.
[8] E. Cohen,et al. Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders. , 2014, Swiss medical weekly.
[9] Han-Chang Huang,et al. Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease , 2014, Neurological research.
[10] S. C. Penley,et al. Use of an eight-arm radial water maze to assess working and reference memory following neonatal brain injury. , 2013, Journal of visualized experiments : JoVE.
[11] Sharon C. Yates,et al. Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease , 2013, Acta neuropathologica communications.
[12] S. Lehr,et al. Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells , 2013, Diabetologia.
[13] W. Thies,et al. 2013 Alzheimer's disease facts and figures , 2013, Alzheimer's & Dementia.
[14] P. Rabinovitch,et al. mTOR is a key modulator of ageing and age-related disease , 2013, Nature.
[15] U. Hille,et al. Lymphedema of the breast as a symptom of internal diseases or side effect of mTor inhibitors. , 2012, Lymphatic research and biology.
[16] A. Ersoy,et al. Everolimus-induced lymphedema in a renal transplant recipient: a case report. , 2012, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
[17] Smita Majumder,et al. Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits , 2011, Alzheimer's & Dementia.
[18] Hao Jiang,et al. Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. , 2012, Cellular signalling.
[19] M. Lacouture,et al. Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review. , 2012, The oncologist.
[20] H. A. van den Berg,et al. Interaction of fast and slow dynamics in endocrine control systems with an application to β-cell dynamics. , 2012, Mathematical biosciences.
[21] J. Kumar,et al. Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells. , 2011, The international journal of biochemistry & cell biology.
[22] A. Caccamo,et al. Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity , 2011, Brain pathology.
[23] A. Caccamo,et al. Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism* , 2011, The Journal of Biological Chemistry.
[24] D. Selkoe. Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.
[25] F. Das,et al. PRAS40 acts as a nodal regulator of high glucose‐induced TORC1 activation in glomerular mesangial cell hypertrophy , 2010, Journal of cellular physiology.
[26] Arlan Richardson,et al. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. , 2010, The Journal of biological chemistry.
[27] Jayanta Debnath,et al. Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease , 2010, PloS one.
[28] A. Kraft,et al. PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells , 2009, Cancer biology & therapy.
[29] F. LaFerla,et al. Aβ inhibits the proteasome and enhances amyloid and tau accumulation , 2008, Neurobiology of Aging.
[30] S. Oddo,et al. The ubiquitin-proteasome system in Alzheimer's disease , 2008, Journal of cellular and molecular medicine.
[31] D. Connor,et al. The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007 , 2007, Cell and Tissue Banking.
[32] B. Winblad,et al. p70 S6 kinase and tau in Alzheimer's disease. , 2008, Journal of Alzheimer's disease : JAD.
[33] R. Roth,et al. PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding* , 2007, Journal of Biological Chemistry.
[34] S. Carr,et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. , 2007, Molecular cell.
[35] Timothy J. Griffin,et al. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.
[36] J. Eckel,et al. Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats , 2006, Diabetes.
[37] D. Diamond,et al. Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice , 2006, Nature Protocols.
[38] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[39] B. Winblad,et al. [Risk factors for dementia and Alzheimer' s disease-findings from a community-based cohort study in Stockholm, Sweden]. , 2005, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.
[40] M. Fleming,et al. Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002* , 2005, Journal of Biological Chemistry.
[41] Heinz H. Bauschke,et al. Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease , 2005, Genes, brain, and behavior.
[42] F. LaFerla,et al. Alzheimer's disease: Aβ, tau and synaptic dysfunction , 2005 .
[43] Frank M LaFerla,et al. Alzheimer's disease: Abeta, tau and synaptic dysfunction. , 2005, Trends in molecular medicine.
[44] N. Mizushima. Methods for monitoring autophagy. , 2004, The international journal of biochemistry & cell biology.
[45] James Lowe,et al. Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders , 2003, Ageing Research Reviews.
[46] H. Braak,et al. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. , 2003, The American journal of pathology.
[47] M. Mattson,et al. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction , 2003, Neuron.
[48] R. Chang,et al. Phosphorylation of eukaryotic initiation factor-2&agr; (eIF2&agr;) is associated with neuronal degeneration in Alzheimer's disease , 2002, Neuroreport.
[49] R. Chang,et al. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. , 2002, Neuroreport.
[50] W. Markesbery,et al. Impaired Proteasome Function in Alzheimer's Disease , 2000, Journal of neurochemistry.
[51] D. Wolf,et al. The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing* , 1997, The Journal of Biological Chemistry.
[52] A. Ott. Risk of dementia: The Rotterdam Study , 1997 .
[53] A. Goldberg,et al. Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation* , 1997, The Journal of Biological Chemistry.
[54] P. O'Brien,et al. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. , 1997, American journal of epidemiology.
[55] A. Berns,et al. Proviral tagging in E mu‐myc transgenic mice lacking the Pim‐1 proto‐oncogene leads to compensatory activation of Pim‐2. , 1995, The EMBO journal.
[56] P. Laird,et al. In vivo analysis of Pim-1 deficiency. , 1993, Nucleic acids research.
[57] R. Reeves,et al. Recombinant human pim-1 protein exhibits serine/threonine kinase activity. , 1991, The Journal of biological chemistry.
[58] A. Berns,et al. The pim‐1 oncogene encodes two related protein‐serine/threonine kinases by alternative initiation at AUG and CUG. , 1991, The EMBO journal.
[59] F. Sigaux,et al. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[60] A. Berns,et al. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors , 1989, Cell.
[61] Wim Quint,et al. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region , 1984, Cell.