T Cells + Cytotoxic Function in Human CD8 MHC Class I Receptors and Acquisition of Coordinated Expression of Ig-Like Inhibitory

MHC class I-specific inhibitory receptors are expressed by a subset of memory-phenotype CD8 (cid:1) T cells. Similar to NK cells, MHC class I-specific inhibitory receptors might subserve on T cells an important negative control that participates to the prevention of autologous damage. We analyzed here human CD8 (cid:1) T cells that express the Ig-like MHC class I-specific inhibitory receptors: killer cell Ig-like receptor (KIR) and CD85j. The cell surface expression of Ig-like inhibitory MHC class I receptors was found to correlate with an advanced stage of CD8 (cid:1) T cell maturation as evidenced by the reduced proliferative potential of KIR (cid:1) and CD85j (cid:1) T cells associated with their high intracytoplasmic perforin content. This concomitant regulation might represent a safety mechanism to control potentially harmful cytolytic CD8 (cid:1) T cells, by raising their activation threshold. Yet, KIR (cid:1) and CD85j (cid:1) T cells present distinct features. KIR (cid:1) CD8 (cid:1) T cells are poor IFN- (cid:2) producers upon TCR engagement. In addition, KIR are barely detectable at the surface of virus-specific T cells during the course of CMV or HIV-1 infection. By contrast, CD85j (cid:1) CD8 (cid:1) T cells produce IFN- (cid:2) upon TCR triggering, and represent a large fraction of virus-specific

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