Nanofluidic devices and their applications.

Recent developments in micro- and nanotechnologies made possible the fabrication of devices integrating a deterministic network of nanochannels, i.e., with at least one dimension in a range from 1 to 100 nm. The proximity of this dimension and the Debye length, the size of biomolecules such as DNA or proteins, or even the slip length, added to the excellent control on the geometry gives unique features to nanofluidic devices. This new class of devices not only finds applications wherever less well-defined porous media, such as electrophoresis gels, have been traditionally used but also give a new insight into the sieving mechanisms of biomolecules and the fluid flow at the nanoscale. Beyond this, the control on the geometry allows smarter design resulting, among others, in new separation principles by taking advantage of the anisotropy. This perspective gives an overview on the fabrication technologies of nanofluidic devices and their applications. In the first part, the current state of the art of nanofluidic fabrication is presented. The second part first discusses the key transport phenomena in nanochannels. Current applications of nanofluidic devices are next discussed. Finally, future challenges and possible applications are highlighted.

[1]  Ali Khademhosseini,et al.  Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing. , 2006, Lab on a chip.

[2]  J. Sweedler,et al.  Nanofluidic injection and heterogeneous kinetics of organomercaptan surface displacement reactions on colloidal gold in a microfluidic stream. , 2006, Analytical chemistry.

[3]  Rui Qiao,et al.  Atomistic simulation of KCl transport in charged silicon nanochannels: Interfacial effects , 2005 .

[4]  Kevin Ke,et al.  Rapidly prototyped three-dimensional nanofluidic channel networks in glass substrates. , 2005, Analytical chemistry.

[5]  A. L. Stevens,et al.  Million-fold preconcentration of proteins and peptides by nanofluidic filter. , 2005, Analytical chemistry.

[6]  John A Rogers,et al.  Optically fabricated three dimensional nanofluidic mixers for microfluidic devices. , 2005, Nano letters.

[7]  R. Segalman.  Patterning with block copolymer thin films , 2005 .

[8]  Kenji Okamoto,et al.  Polymer nanochannels fabricated by thermomechanical deformation for single-molecule analysis. , 2005, Analytical chemistry.

[9]  H. Yin,et al.  Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip. , 2005, Analytical chemistry.

[10]  Shaorong Liu,et al.  Ion-Enrichment and Ion-Depletion Effect of Nanochannel Structures , 2004 .

[11]  J. Korlach,et al.  Focal volume confinement by submicrometer-sized fluidic channels. , 2004, Analytical chemistry.

[12]  J. Korlach,et al.  DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels. , 2002, Analytical chemistry.

[13]  S S Chan,et al.  Separation of 100-kilobase DNA molecules in 10 seconds. , 2001, Analytical chemistry.

[14]  H. Craighead,et al.  Nanofabricated refractive index sensor based on photon tunneling in nanofluidic channel , 2001 .

[15]  S. Jacobson,et al.  Microfabricated porous membrane structure for sample concentration and electrophoretic analysis. , 1999, Analytical chemistry.

[16]  K. Lakin,et al.  Chemical vapor deposition of silicon using a CO2 laser , 1978 .