Microarrays: biotechnology's discovery platform for functional genomics.

Advances in microarray technology enable massive parallel mining of biological data, with biological chips providing hybridization-based expression monitoring, polymorphism detection and genotyping on a genomic scale. Microarrays containing sequences representative of all human genes may soon permit the expression analysis of the entire human genome in a single reaction. These 'genome chips' will provide unprecedented access to key areas of human health, including disease prognosis and diagnosis, drug discovery, toxicology, aging, and mental illness. Microarray technology is rapidly becoming a central platform for functional genomics.

[1]  E. Lander.  The New Genomics: Global Views of Biology , 1996, Science.

[2]  D. Pinkel,et al.  Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors , 2022 .

[3]  R. Sapolsky,et al.  Mapping genomic library clones using oligonucleotide arrays. , 1996, Genomics.

[4]  P. Brown,et al.  Exploring the metabolic and genetic control of gene expression on a genomic scale. , 1997, Science.

[5]  S. P. Fodor.  DNA SEQUENCING: Massively Parallel Genomics , 1997, Science.

[6]  A. Blanchard,et al.  High-density oligonucleotide arrays , 1996 .

[7]  S Falkow,et al.  Microbial pathogenesis: genomics and beyond. , 1997, Science.

[8]  E. Southern,et al.  Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ. , 1992, Nucleic acids research.

[9]  L. Wodicka,et al.  Genome-wide expression monitoring in Saccharomyces cerevisiae , 1997, Nature Biotechnology.

[10]  J. Hoheisel.  Oligomer-chip technology , 1997 .

[11]  S. P. Fodor,et al.  Light-directed, spatially addressable parallel chemical synthesis. , 1991, Science.

[12]  V. Agol.  [Internal initiation of translation in eukaryotes]. , 1991, Molekuliarnaia biologiia.

[13]  Ronald W. Davis,et al.  Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar–coding strategy , 1996, Nature Genetics.

[14]  E. Southern,et al.  DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale. , 1996, Trends in genetics : TIG.

[15]  Ronald W. Davis,et al.  Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray , 1995, Science.

[16]  M. Boguski,et al.  Functional genomics: it's all how you read it. , 1997, Science.

[17]  James L. Winkler,et al.  Accessing Genetic Information with High-Density DNA Arrays , 1996, Science.

[18]  L. Penland,et al.  Use of a cDNA microarray to analyse gene expression patterns in human cancer , 1996, Nature Genetics.

[19]  M. Schena.  Genome analysis with gene expression microarrays. , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

[20]  R. Reich,et al.  A microchip for quantitative detection of molecules utilizing luminescent and radioisotope reporter groups. , 1994, BioTechniques.

[21]  G. Mahairas,et al.  Sequencing the human genome. , 1997, Science.