Photodermatitis from tetrazepam

Case Report A 35-year-old woman was treated for sciatica with ibuprofen 400 mg oral 3¿ daily, and diazepam 5 mg oral at night. One night, she also took 50 mg oral tetrazepam because of muscle spasm. The following day, after sun exposure in the morning, she developed an itchy micropapular rash on sun-exposed areas. Treatment was discontinued and the eruption cleared with skin desquamation in 10 days. She needed therapy with systemic antihistamines and corticosteroids. Patch and photopatch tests were performed (Table 1). Oral photochallenge tests were made with ibuprofen and diazepam separately. She tolerated both drugs without problems. Oral photochallenge test with tetrazepam was performed, with reappearance of the skin eruption.