anticoagulant (LA) was present in 69/323 patients (21.4%). aCL were more frequent in patients with seizures than in those without (59.2% vs. 24.7%, RR 3.8 [95%CI 1.8-7.9], p=0.0004). Both IgG and IgM aCL were more frequently found in patients with seizures than in those without (52% vs. 20%, RR 3.6 [95%CI 1.8-7.3], p=0.0006 and 22% vs 7.5%, RR 3.0 [95%CI 1.36.8], p=0.02, respectively). LA was more frequently found in patients with seizures than in those without (25.9% vs 20.6%), but the difference was not statistically significant. Patients were subdivided in those who presented PS and those who presented GS. Patients with PS presented more frequently IgM than those without (25% vs 8%, RR 3.5 [95%CI 1.2-10.1], p=0.04). Patients with GS presented more frequently IgG aCL than those without (60% vs 21.5%, RR 5.1 [95%CI 1.5-17.6], p=0.01). After excluding all patients who had concomitant CVD, the association of PS with IgM aCL and GS with IgG aCL remained significant. Conclusions: aCL are frequently found in SLE patients with seizures, sug