Membrane association and targeting of prenylated Ras-like GTPases.

[1]  P. Casey,et al.  Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase* , 1997, The Journal of Biological Chemistry.

[2]  J. Rine,et al.  Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis , 1997, Science.

[3]  P. Casey,et al.  Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution , 1997, Science.

[4]  J. Hartwig,et al.  Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane , 1997, Journal of leukocyte biology.

[5]  M. Yamamoto,et al.  Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis , 1997, Molecular and cellular biology.

[6]  S. Pfeffer,et al.  Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab–GDI , 1997, The EMBO journal.

[7]  P. Auvinen,et al.  Endosome dynamics regulated by a Rho protein , 1996, Nature.

[8]  I. Wilson,et al.  Structural insights into the function of the Rab GDI superfamily. , 1996, Trends in biochemical sciences.

[9]  Richard G. W. Anderson,et al.  A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane* , 1996, The Journal of Biological Chemistry.

[10]  M. Resh.  Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. , 1996, Cellular signalling.

[11]  R. Rando.  Chemical biology of isoprenylation/methylation. , 1996, Biochemical Society transactions.

[12]  M. Seabra,et al.  Geranylgeranylation of Rab proteins. , 1996, Biochemical Society transactions.

[13]  M. Seabra.  Nucleotide Dependence of Rab Geranylgeranylation , 1996, The Journal of Biological Chemistry.

[14]  M. Seabra.  New insights into the pathogenesis of choroideremia: a tale of two REPs. , 1996, Ophthalmic genetics.

[15]  Richard G. W. Anderson,et al.  Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane (*) , 1996, The Journal of Biological Chemistry.

[16]  R. Erdman,et al.  Association of Rab1B with GDP-dissociation Inhibitor (GDI) Is Required for Recycling but Not Initial Membrane Targeting of the Rab Protein (*) , 1996, The Journal of Biological Chemistry.

[17]  M. Lisanti,et al.  Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains , 1996, The Journal of Biological Chemistry.

[18]  D. Bar-Sagi,et al.  The Ras superfamily of GTPases 1 , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  M. Seabra,et al.  Mechanism of Digeranylgeranylation of Rab Proteins , 1996, The Journal of Biological Chemistry.

[20]  J. Yu,et al.  GDP Dissociation Inhibitor Serves as a Cytosolic Acceptor for Newly Synthesized and Prenylated Rab5 (*) , 1995, The Journal of Biological Chemistry.

[21]  A. Kral,et al.  Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice , 1995, Nature Medicine.

[22]  P. Casey,et al.  Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. , 1995, Biochemistry.

[23]  P. Adamson,et al.  Ultrastructural localization of ras-related proteins using epitope-tagged plasmids. , 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[24]  M. Gelb,et al.  Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling. , 1995, Biochemistry.

[25]  M. Gelb,et al.  Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[26]  P. Conrad,et al.  Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation , 1994, The Journal of cell biology.

[27]  M. Zerial,et al.  Rab escort protein‐1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. , 1994, The EMBO journal.

[28]  P. Casey,et al.  Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. , 1994, The Journal of biological chemistry.

[29]  S. Pfeffer.  Rab GTPases: master regulators of membrane trafficking. , 1994, Current opinion in cell biology.

[30]  M. Zerial,et al.  Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex. , 1994, Journal of cell science.

[31]  P. Novick,et al.  No exchange without receipt , 1994, Nature.

[32]  F. L'Heureux,et al.  Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. , 1994, Biochemistry.

[33]  M. Zerial,et al.  Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange , 1994, Nature.

[34]  C. Farnsworth,et al.  Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes. , 1994, Annual review of cell biology.

[35]  Mark S. Boguski,et al.  Proteins regulating Ras and its relatives , 1993, Nature.

[36]  R. Rando,et al.  Endoproteolysis of non‐CAAX‐containing isoprenylated peptides , 1993, FEBS letters.

[37]  M. Gelb,et al.  A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide. , 1993, Biochemistry.

[38]  M. Zerial,et al.  Rab GTPases in vesicular transport. , 1993, Current opinion in cell biology.

[39]  A. Levinson,et al.  Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. , 1993, Science.

[40]  Miguel C. Seabra,et al.  cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein , 1993, Cell.

[41]  C J Marshall,et al.  Protein prenylation: a mediator of protein-protein interactions. , 1993, Science.

[42]  M. Brown,et al.  Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. , 1993, Science.

[43]  P. Adamson,et al.  Intracellular localization of the P21rho proteins , 1992, The Journal of cell biology.

[44]  T. Südhof,et al.  Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. , 1992, The Journal of biological chemistry.

[45]  S. Clarke,et al.  Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif. , 1992, The Journal of biological chemistry.

[46]  S. Clarke,et al.  Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. , 1992, Annual review of biochemistry.

[47]  C J Marshall,et al.  A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. , 1991, The EMBO journal.

[48]  M. Zerial,et al.  Hypervariable C-termmal domain of rab proteins acts as a targeting signal , 1991, Nature.

[49]  M. Gelb,et al.  C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. de Gunzburg,et al.  Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Frank McCormick,et al.  The GTPase superfamily: conserved structure and molecular mechanism , 1991, Nature.

[52]  C. Marshall,et al.  A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21 ras to the plasma membrane , 1990, Cell.

[53]  P. Casey,et al.  Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides , 1990, Cell.

[54]  T. Sasaki,et al.  Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. , 1990, The Journal of biological chemistry.

[55]  C. Marshall,et al.  All ras proteins are polyisoprenylated but only some are palmitoylated , 1989, Cell.

[56]  J. Hancock,et al.  Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis. , 1989, The EMBO journal.

[57]  D. Lowy,et al.  The p21 ras C-terminus is required for transformation and membrane association , 1984, Nature.