Regional Differences in Incident Prefrailty and Frailty

Abstract Background and Objectives: The extent to which greater frailty among American compared with European women reflects individual-level characteristics has not been well studied. To test the hypothesis that cardiometabolic conditions and depression and anxiety confound the relationship between region and incident prefrailty and frailty in American compared with European women. Materials and Methods: The Global Longitudinal Study of Osteoporosis in Women (GLOW) is a 5-year observational cohort study of women aged ≥55 years. A total of 19,674 participants from the United States and Europe were nonfrail at baseline and provided information on characteristics, including body mass index, depression and anxiety, and cardiovascular disease. We used multivariable Cox proportional hazards models to examine the relationship between region and incident frailty and prefrailty. Results: Over 40% of respondents became prefrail or frail during follow-up. Adjusting for age, body mass index, depression and anxiety, ...

[1]  M. Castell,et al.  Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on OSteoArthritis (EPOSA) , 2015, BMC Musculoskeletal Disorders.

[2]  R. Kenny,et al.  Factor structure for the frailty syndrome was consistent across Europe. , 2014, Journal of clinical epidemiology.

[3]  Kenneth Rockwood,et al.  Exploring the relationship between national economic indicators and relative fitness and frailty in middle-aged and older Europeans. , 2013, Age and ageing.

[4]  S. Lord,et al.  A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial , 2013, BMC Medicine.

[5]  A. LaCroix,et al.  Frailty and Fracture, Disability, and Falls: A Multiple Country Study From the Global Longitudinal Study of Osteoporosis in Women , 2013, Journal of the American Geriatrics Society.

[6]  L. Fried,et al.  Hyperglycemia and Incidence of Frailty and Lower Extremity Mobility Limitations in Older Women , 2012, Journal of the American Geriatrics Society.

[7]  A. LaCroix,et al.  Antidepressant Use, Depressive Symptoms, and Incident Frailty in Women Aged 65 and Older from the Women's Health Initiative Observational Study , 2012, Journal of the American Geriatrics Society.

[8]  A. Burdorf,et al.  Socio-demographic determinants of worsening in frailty among community-dwelling older people in 11 European countries , 2012, Journal of Epidemiology & Community Health.

[9]  L. Rodriguez-Manas,et al.  The prevalence of frailty syndrome in an older population from Spain. The Toledo study for healthy aging , 2011, The journal of nutrition, health & aging.

[10]  I. Lang,et al.  Frailty, body mass index, and abdominal obesity in older people. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  D. Melzer,et al.  Neighborhood Deprivation, Individual Socioeconomic Status, and Frailty in Older Adults , 2009, Journal of the American Geriatrics Society.

[12]  J. Spagnoli,et al.  Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  A. LaCroix,et al.  The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design , 2009, Osteoporosis International.

[14]  Aaron Aragaki,et al.  Frailty: Emergence and Consequences in Women Aged 65 and Older in the Women's Health Initiative Observational Study , 2005, Journal of the American Geriatrics Society.

[15]  Kenneth Rockwood,et al.  Frailty and Its Definition: A Worthy Challenge , 2005, Journal of the American Geriatrics Society.

[16]  J. E. Brazier,et al.  Using the SF-36 and Euroqol on an elderly population , 1996, Quality of Life Research.

[17]  S. Cummins,et al.  Place effects on health: how can we conceptualise, operationalise and measure them? , 2002, Social science & medicine.

[18]  D. Kromhout.  Epidemiology of cardiovascular diseases in Europe , 2001, Public Health Nutrition.

[19]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  Olga V. Demler,et al.  Cross-national comparisons of the prevalences and correlates of mental disorders. WHO International Consortium in Psychiatric Epidemiology. , 2000, Bulletin of the World Health Organization.