3D Micropatterned All-Flexible Microfluidic Platform for Microwave-Assisted Flow Organic Synthesis.

A large-area, all-flexible, microwaveable polydimethoxysilane microfluidic reactor was fabricated by using a 3D printing system. The sacrificial microchannels were printed on polydimethoxysilane substrates by a direct ink writing method using water-soluble Pluronic F-127 ink and then encapsulated between polydimethoxysilane layers. The structure of micron-sized channels was analyzed by optical and electron microscopy techniques. The fabricated flexible microfluidic reactors were utilized for the acetylation of different amines under microwave irradiation to obtain acetamides in shorter reaction times and good yields by flow organic synthesis.

[1]  J. Lewis,et al.  Fugitive Inks for Direct‐Write Assembly of Three‐Dimensional Microvascular Networks , 2005 .

[2]  Heejin Kim,et al.  Integrated one-flow synthesis of heterocyclic thioquinazolinones through serial microreactions with two organolithium intermediates. , 2015, Angewandte Chemie.

[3]  S. Ohla,et al.  On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale. , 2016, Lab on a chip.

[4]  George M Whitesides,et al.  Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane). , 2006, Angewandte Chemie.

[5]  Anthony K. Au,et al.  Mikrofluidik aus dem 3D‐Drucker , 2016 .

[6]  S. Yoo,et al.  Creating perfused functional vascular channels using 3D bio-printing technology. , 2014, Biomaterials.

[7]  Jae-Woong Jeong,et al.  Microfluidic neural probes: in vivo tools for advancing neuroscience. , 2017, Lab on a chip.

[8]  Matthew J. Bruzek,et al.  Microfluidic generation of droplets with a high loading of nanoparticles. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[9]  Steven V Ley,et al.  Microwave reactions under continuous flow conditions. , 2007, Combinatorial chemistry & high throughput screening.

[10]  J. A. Lewis.  Direct Ink Writing of 3D Functional Materials , 2006 .

[11]  J. Lewis,et al.  3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs , 2014, Advanced materials.

[12]  Thomas Glinsner,et al.  High resolution lithography with PDMS molds , 2004 .

[13]  K. Jensen,et al.  A Continuous‐Flow Microcapillary Reactor for the Preparation of a Size Series of CdSe Nanocrystals , 2003 .

[14]  T. Fujii.  PDMS-based microfluidic devices for biomedical applications , 2002 .

[15]  C. R. Strauss,et al.  Developments in Microwave-Assisted Organic Chemistry , 1995 .

[16]  J. Kobayashi,et al.  Multiphase organic synthesis in microchannel reactors. , 2006, Chemistry, an Asian journal.

[17]  Ali Abou-Hassan,et al.  Mikrofluidik in der anorganischen Chemie , 2010 .

[18]  J. Eijkel,et al.  Improving the Resolution of 3D-Printed Molds for Microfluidics by Iterative Casting-Shrinkage Cycles. , 2017, Analytical chemistry.

[19]  C. Garrett,et al.  Two-Photon Excitation in CaF 2 : Eu 2+ , 1961 .

[20]  A. Khademhosseini,et al.  Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. , 2014, Lab on a chip.

[21]  Philip J. Kitson,et al.  Configurable 3D-Printed millifluidic and microfluidic 'lab on a chip' reactionware devices. , 2012, Lab on a chip.

[22]  Gerald Richter,et al.  Efficient Terpene Synthase Catalysis by Extraction in Flow. , 2013, ChemPlusChem.

[23]  Peter Ertl,et al.  Nanobiotechnology advanced antifouling surfaces for the continuous electrochemical monitoring of glucose in whole blood using a lab-on-a-chip. , 2013, Lab on a chip.

[24]  Mats Larhed,et al.  Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications , 2012 .

[25]  A. Khademhosseini,et al.  Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink , 2016, Advanced materials.

[26]  M. Uehara,et al.  Highly Luminescent CdSe/ZnS Nanocrystals Synthesized Using a Single‐Molecular ZnS Source in a Microfluidic Reactor , 2005 .

[27]  A. deMello,et al.  A Microfluidic Approach to the Rapid Screening of Palladium-Catalysed Aminocarbonylation Reactions , 2009 .

[28]  K. Mae,et al.  Development of a New Microreactor Based on Annular Microsegments for Fine Particle Production , 2006 .

[29]  J. Lewis,et al.  Self‐Healing Materials with Interpenetrating Microvascular Networks , 2009 .

[30]  Albert Folch,et al.  3D-Printed Microfluidics. , 2016, Angewandte Chemie.

[31]  Yong Chen,et al.  A Fast Mask Projection Stereolithography Process for Fabricating Digital Models in Minutes , 2012 .

[32]  Eamon Comer,et al.  A microreactor for microwave-assisted capillary (continuous flow) organic synthesis. , 2005, Journal of the American Chemical Society.

[33]  Michael C. McAlpine,et al.  3D printed nervous system on a chip. , 2016, Lab on a chip.

[34]  Satoshi Kawata,et al.  Finer features for functional microdevices , 2001, Nature.

[35]  T. Fujii,et al.  Handling of Picoliter Liquid Samples in a Poly(dimethylsiloxane)-Based Microfluidic Device , 1999 .

[36]  A Paul Alivisatos,et al.  High-temperature microfluidic synthesis of CdSe nanocrystals in nanoliter droplets. , 2005, Journal of the American Chemical Society.

[37]  G. Jabbour,et al.  Inkjet Printing—Process and Its Applications , 2010, Advanced materials.

[38]  R. Luque,et al.  Liquid phase oxidation chemistry in continuous-flow microreactors. , 2016, Chemical Society reviews.

[39]  Liang Yu,et al.  A two-phase segmented microfluidic technique for one-step continuous versatile preparation of zeolites , 2013 .

[40]  Chenjie Xu,et al.  Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing. , 2017, Lab on a chip.

[41]  Alessandra Puglisi,et al.  Additive Manufacturing Technologies: 3D Printing in Organic Synthesis , 2018 .

[42]  E. Kumacheva,et al.  Continuous microfluidic reactors for polymer particles. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[43]  J. Lewis,et al.  Omnidirectional Printing of 3D Microvascular Networks , 2011, Advanced materials.

[44]  M. Breadmore,et al.  One-Step Fabrication of a Microfluidic Device with an Integrated Membrane and Embedded Reagents by Multimaterial 3D Printing. , 2017, Analytical chemistry.

[45]  Sidra Waheed,et al.  3D printed microfluidic devices: enablers and barriers. , 2016, Lab on a chip.

[46]  Leslie Y Yeo,et al.  Microfluidic devices for bioapplications. , 2011, Small.

[47]  Rakhi Singh,et al.  Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems , 2016, Korean Journal of Chemical Engineering.

[48]  Liang Ma,et al.  Coaxial nozzle-assisted 3D bioprinting with built-in microchannels for nutrients delivery. , 2015, Biomaterials.

[49]  S. Rossi,et al.  Stereoselective Catalytic Synthesis of Active Pharmaceutical Ingredients in Homemade 3D-Printed Mesoreactors. , 2017, Angewandte Chemie.

[50]  Changqing Yi,et al.  Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications - a review. , 2017, Lab on a chip.

[51]  George M. Whitesides,et al.  An Axisymmetric Flow‐Focusing Microfluidic Device , 2005 .

[52]  Benjamin A. Wilhite,et al.  CONTINUOUS-FLOW PREPARATION OF BIODIESEL USING MICROWAVE HEATING , 2007 .

[53]  Jurriaan Huskens,et al.  Supported Catalysis in Continuous-Flow Microreactors , 2015 .

[54]  Dishit P. Parekh,et al.  3D printing of liquid metals as fugitive inks for fabrication of 3D microfluidic channels. , 2016, Lab on a chip.

[55]  Valérie Cabuil,et al.  Microfluidics in inorganic chemistry. , 2010, Angewandte Chemie.

[56]  G. Whitesides,et al.  Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. , 2003, Analytical chemistry.

[57]  Ali Khademhosseini,et al.  Microfluidics for drug discovery and development: from target selection to product lifecycle management. , 2008, Drug discovery today.

[58]  Savas Tasoglu,et al.  3D-printed microfluidic devices , 2016, Biofabrication.

[59]  A. Folch,et al.  3D-printing of transparent bio-microfluidic devices in PEG-DA. , 2016, Lab on a chip.