Calcium entry blocking drugs: mechanisms of action, experimental studies and clinical uses.

[1]  S. Vatner,et al.  Effects of a Calcium‐channel Antagonist on Large and Small Coronary Arteries in Conscious Dogs , 1982, Circulation.

[2]  W. Paulus,et al.  Modification of Abnormal Left Ventricular Diastolic Properties by Nifedipine in Patients with Hypertrophic Cardiomyopathy , 1982, Circulation.

[3]  B. Folkow,et al.  Importance of Adaptive Changes in Vascular Design for Establishment of Primary Hypertension, Studied in Man and in Spontaneously Hypertensive Rats , 1973, Circulation research.

[4]  F. Bühler,et al.  Calcium channel blockers: a pathophysiologically based antihyper onsive treatment concept for the future? , 1982, European journal of clinical investigation.

[5]  F. Finnerty.  NEWER ANTIHYPERTENSIVE DRUGS. , 1964, The Medical clinics of North America.

[6]  W. Boden,et al.  The Effect of Verapamil on Mechanical Performance of Acutely Ischemic and Reperfused Myocardium in the Conscious Dog , 1981, Circulation research.

[7]  C. Porter,et al.  Beneficial hemodynamic effects of intravenous and oral diltiazem in severe congestive heart failure. , 1984, Journal of the American College of Cardiology.

[8]  R. Tarazi,et al.  Dependence of arterial pressure on intravascular volume in treated hypertensive patients. , 1972, The New England journal of medicine.

[9]  D. Gillmer,et al.  Pulmonary oedema precipitated by nifedipine. , 1980, British medical journal.

[10]  V. R. Richards,et al.  Nifedipine Kinetics and Bioavailability After Single Intravenous and Oral Doses in Normal Subjects , 1983, Journal of clinical pharmacology.

[11]  R. W. Brower,et al.  Afterload reduction with nifedipine in aortic insufficiency. , 1982, The American journal of cardiology.

[12]  J. Weil,et al.  Plasma Volume Expansion Resulting from Interference with Adrenergic Function in Normal Man , 1968, Circulation.

[13]  F. M. Bumpus,et al.  Collagen synthesis in development and reversal of cardiac hypertrophy in spontaneously hypertensive rats. , 1979, The American journal of cardiology.

[14]  J. Sommer,et al.  Pharmacokinetics and metabolism of nifedipine. , 1983, Hypertension.

[15]  S Ringer,et al.  A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart , 1883, The Journal of physiology.

[16]  E. Antman,et al.  Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. , 1980, The New England journal of medicine.

[17]  Michael V. Green,et al.  Effects of verapamil and propranolol on left ventricular systolic function and diastolic filling in patients with coronary artery disease: radionuclide angiographic studies at rest and during exercise. , 1982, Circulation.

[18]  J. Parker,et al.  Oral isosorbide dinitrate in angina pectoris: comparison of duration of action an dose-response relation during acute and sustained therapy. , 1982, The American journal of cardiology.

[19]  B. Mehlman,et al.  Pathologic changes induced by 1-norepinephrine , 1960 .

[20]  E. Frohlich,et al.  Effect of methyldopa, clonidine, and hydralazine on cardiac mass and haemodynamics in Wistar Kyoto and spontaneously hypertensive rats. , 1982, Cardiovascular research.

[21]  K. Mcintyre,et al.  Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: report of a cooperative clinical trial. , 1982, The American journal of cardiology.

[22]  K. Brouwer,et al.  Effects of phenobarbital and SKF-525A on in vitro hepatic metabolism of verapamil and nifedipine. , 1985, Pharmacology.

[23]  H. Motulsky,et al.  Hypotension after quinidine plus verapamil. Possible additive competition at alpha-adrenergic receptors. , 1985, The New England journal of medicine.

[24]  R. Tarazi,et al.  Cardiac Hypertrophy in Spontaneously Hypertensive Rats , 1974, Circulation research.

[25]  H. Brown,et al.  The Relative Contributions of Various Time-Dependent Membrane Currents to Pacemaker Activity in the Sino Atrial Node , 1982 .

[26]  B. Chaitman,et al.  Beneficial Effect of Intravenous Diltiazem in the Acute Management of Paroxysmal Supraventricular Tachyarrhythmias , 1983, Circulation.

[27]  S. Epstein,et al.  Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy. , 1981, Circulation.

[28]  M. Bortolotti,et al.  Clinical and manometric effects of nifedipine in patients with esophageal achalasia. , 1981, Gastroenterology.

[29]  J. Muller,et al.  Therapy of coronary vasoconstriction in patients with coronary artery disease. , 1981, The American journal of cardiology.

[30]  S. Matsumoto,et al.  Hemodynamic effects of nifedipine in congestive heart failure. , 1980, The American journal of cardiology.

[31]  T. Godfraind.  Actions of nifedipine on calcium fluxes and contraction in isolated rat arteries. , 1983, The Journal of pharmacology and experimental therapeutics.

[32]  M. Endo,et al.  Calcium release from the sarcoplasmic reticulum. , 1977, Physiological reviews.

[33]  J. Mason,et al.  Comparative clinical electrophysiologic effects of diltiazem, verapamil and nifedipine: a review. , 1982, The American journal of cardiology.

[34]  E. Kinney,et al.  The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers , 1981, Journal of clinical pharmacology.

[35]  S. Winegrad.  Regulation of cardiac contractile proteins. Correlations between physiology and biochemistry. , 1984, Circulation research.

[36]  C. R. Ingram,et al.  Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. , 1983, The New England journal of medicine.

[37]  H. Carrasco,et al.  Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome. , 1978, American heart journal.

[38]  D. Hartshorne.  Biochemical basis for contraction of vascular smooth muscle. , 1980, Chest.

[39]  E. Kaplinsky,et al.  The Acute Hemodynamic Effects of Intravenous Verapamil in Coronary Artery Disease Assessment by Equilibrium-gated Radionuclide Ventriculography , 1983, Circulation.

[40]  J. Hung,et al.  Termination of paroxysmal supraventricular tachycardia with a single oral dose of diltiazem and propranolol. , 1985, Circulation.

[41]  F. Camerini,et al.  Haemodynamic effects of nifedipine in heart failure. , 1980, British heart journal.

[42]  E. Braunwald,et al.  Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. , 1957, The American journal of physiology.

[43]  A. Katz.  Physiology of the heart , 1977 .

[44]  K. Andersson.  Pharmacological Inhibition of Uterine Activity , 1982, Acta obstetricia et gynecologica Scandinavica. Supplement.

[45]  R. Tsien,et al.  Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells , 1983, Nature.

[46]  E. Frohlich,et al.  Systemic hemodynamic effects of microspheres in conscious rats. , 1977, The American journal of physiology.

[47]  F. Dunn,et al.  Hemodynamic Correlates of Saralasin‐induced Arterial Pressure Changes , 1978, Circulation.

[48]  J. Muller,et al.  Inappropriate coronary vasoconstriction in patients with coronary artery disease: a role for nifedipine? , 1979, The American journal of cardiology.

[49]  M. Sanguinetti,et al.  Voltage‐Dependent Block of Calcium Channel Current in the Calf Cardiac Purkinje Fiber by Dihydropyridine Calcium Channel Antagonists , 1984, Circulation research.

[50]  N. Takekoshi,et al.  Hemodynamic effects of sublingual nifedipine in congestive heart failure. , 1980, Japanese circulation journal.

[51]  B. Lewis,et al.  Immediate haemodynamic effects of verapamil in man. , 1975, Cardiology.

[52]  C. Porter,et al.  Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. , 1983, Circulation.

[53]  E. Frohlich,et al.  Disparate effects of methyldopa and clonidine on cardiac mass and haemodynamics in rats. , 1980, Clinical science.

[54]  R. Robson,et al.  Nifedipine and beta-blockade as a cause of cardiac failure. , 1982, British medical journal.

[55]  P. Erne,et al.  Factors influencing the hypotensive effects of calcium antagonists. , 1983, Hypertension.

[56]  A. Castellanos,et al.  Electrophysiologic effects of diltiazem hydrochloride on supraventricular tachycardia. , 1982, The American journal of cardiology.

[57]  Vanhoutte Pm.  Calcium-entry blockers and vascular smooth muscle , 1982 .

[58]  C. Dollery,et al.  The clinical pharmacology of beta-adrenoceptor-blocking drugs. , 1976, Progress in cardiovascular diseases.

[59]  A. Fabiato,et al.  Calcium and cardiac excitation-contraction coupling. , 1979, Annual review of physiology.

[60]  J. Moses,et al.  Efficacy of nifedipine in rest angina refractory to propranolol and nitrates in patients with obstructive coronary artery disease. , 1981, Annals of internal medicine.

[61]  M. Olivari,et al.  Clinical use of a calcium antagonistic agent (nifedipine) in acute pulmonary edema. , 1979, The American journal of medicine.

[62]  J. Douglas.  Hemodynamic effects of nifedipine in primary pulmonary hypertension. , 1983, Journal of the American College of Cardiology.

[63]  G. Raff,et al.  Hypertrophic cardiomyopathy--therapy with slow channel inhibiting agents. , 1982, Progress in cardiovascular diseases.

[64]  R. Graham,et al.  DIFFERING EFFECTS OF THE VASODILATOR DRUGS, PRAZOSIN AND DIAZOXIDE ON PLASMA RENIN ACTIVITY IN THE DOG , 1976, Clinical and experimental pharmacology & physiology.

[65]  E. Antman,et al.  Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. , 1980, Annals of internal medicine.

[66]  E. Frohlich,et al.  Hemodynamic comparison of agents useful in hypertensive emergencies , 1973 .

[67]  M. McGregor.  The nitrates and myocardial ischemia. , 1982, Circulation.

[68]  R. Chahine,et al.  Interim report of multicenter double-blind, placebo-controlled studies of nifedipine in chronic stable angina. , 1981, The American journal of medicine.

[69]  W. E. Craig,et al.  Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation? , 1983, Journal of the American College of Cardiology.

[70]  R. Bonow,et al.  Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris. , 1981, The American journal of cardiology.

[71]  R. Tarazi,et al.  Biochemical changes associated with development and reversal of cardiac hypertrophy in spontaneously hypertensive rats. , 1976, Cardiovascular research.

[72]  R. G. Mcallister.  Clinical pharmacology of slow channel blocking agents. , 1982, Progress in cardiovascular diseases.

[73]  L. Becker,et al.  Protective effect of early and late treatment with nifedipine during myocardial infarction in the conscious dog. , 1984, Circulation.

[74]  H. Hecht,et al.  Influence of severity of ventricular dysfunction on hemodynamic responses to intravenously administered verapamil in ischemic heart disease. , 1981, The American journal of cardiology.

[75]  E. Ritman,et al.  Effect of verapamil on left ventricular function: a randomized, placebo-controlled study. , 1983, The American journal of cardiology.

[76]  I. Grupp,et al.  Differential cardiovascular effects of calcium channel blocking agents: potential mechanisms. , 1982, The American journal of cardiology.

[77]  D. Yellon,et al.  Sustained limitation of myocardial necrosis 24 hours after coronary artery occlusion: verapamil infusion in dogs with small myocardial infarcts. , 1983, The American journal of cardiology.

[78]  F. Dunn,et al.  Effect of blood pressure control on left ventricular hypertrophy in patients with essential hypertension. , 1980, Clinical science.

[79]  J. Ferlinz,et al.  Hemodynamic and myocardial performance characteristics after verapamil use in congestive heart failure , 1983 .

[80]  R. O'rourke,et al.  Differential effects of systemic and intracoronary calcium channel blocking agents on global and regional left ventricular function in conscious dogs. , 1981, American heart journal.

[81]  J. Schroeder,et al.  Diltiazem for long-term therapy of coronary arterial spasm. , 1982, The American journal of cardiology.

[82]  L. Décourt,et al.  Effect of verapamil on regional coronary and myocardial perfusion during acute coronary occlusion. , 1980, The American journal of cardiology.

[83]  J. Ross,et al.  Effects of a calcium-entry blocker (diltiazem) on regional myocardial flow and function during exercise in conscious dogs. , 1984, Circulation.

[84]  S. Chierchia,et al.  Significance of spasm in the pathogenesis of ischemic heart disease. , 1979, The American journal of cardiology.

[85]  C. McKay,et al.  Differences in hemodynamic response to vasodilation due to calcium channel antagonism with nifedipine and direct-acting agonism with hydralazine in chronic refractory congestive heart failure. , 1984, The American journal of cardiology.

[86]  E. S. Weiss,et al.  Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. , 1977, The American journal of physiology.

[87]  C. Anastassiades.  Nifedipine and beta-blocker drugs. , 1980, British medical journal.

[88]  W. C. Hülsmann,et al.  Paradoxical Influence of Calcium Ions on the Permeability of the Cell Membranes of the Isolated Rat Heart , 1966, Nature.

[89]  T. Rimele,et al.  Differential effects of calcium entry blockers on vascular smooth muscle , 1984 .

[90]  L. Hillis,et al.  A controlled trial of verapamil for Prinzmetal's variant angina. , 1981, The New England journal of medicine.

[91]  E. Sonnenblick,et al.  Superiority of Verapamil to Propranolol in Stable Angina Pectoris A Double-blind, Randomized Crossover Trial , 1982, Circulation.

[92]  F. Bühler,et al.  Calcium channel inhibitors for identification of mechanisms and treatment of hypertension. , 1982, Journal of cardiovascular pharmacology.

[93]  R. Loutzenhiser,et al.  Mechanisms of calcium antagonist-induced vasodilation. , 1983, Annual review of pharmacology and toxicology.

[94]  F. Magrini,et al.  Nifedipine, a new antihypertensive with rapid action , 1977, Clinical pharmacology and therapeutics.

[95]  M. Bertrand,et al.  Detrimental effect of propranolol in patients with coronary arterial spasm countered by combination with diltiazem. , 1983, The American journal of cardiology.

[96]  D. Warltier,et al.  Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist. , 1981, The Journal of pharmacology and experimental therapeutics.

[97]  B. Maron,et al.  Verapamil therapy: a new approach to pharmacologic treatment of hypertrophic cardiomyopathy. , 1980, Chest.

[98]  P. Epstein,et al.  Interaction of calcium antagonists with cyclic AMP phosphodiesterases and calmodulin. , 1982, Biochemical and biophysical research communications.

[99]  M. Spedding.  Direct inhibitory effects of some ‘calcium‐antagonists’ and trifluoperazine on the contractile proteins in smooth muscle , 1983, British journal of pharmacology.

[100]  J. Williamson,et al.  Effects of Nifedipine on Myocardial Perfusion and Ischemic Injury in Dogs , 1978, British journal of clinical practice. Supplement.

[101]  Nayler Wg.  Cardioprotective effects of calcium ion antagonists in myocardial ischemia. , 1980 .

[102]  J. Muller,et al.  Prevention by Nifedipine of Abnormal Coronary Vasoconstriction in Patients with Coronary Artery Disease , 1981, Circulation.

[103]  R. Bache,et al.  Effect of nifedipine on myocardial blood flow during exercise in dogs with chronic coronary artery occlusion. , 1984, Journal of the American College of Cardiology.

[104]  M. Pfeffer,et al.  Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[105]  S. Chierchia,et al.  Coronary artery spasm: demonstration, definition, diagnosis, and consequences. , 1982, Progress in cardiovascular diseases.

[106]  E. Frohlich,et al.  A Hemodynamic Comparison of Essential and Renovascular Hypertension: Cardiac Output and Total Peripheral Resistance Supine and Tilted Patients , 1967, Circulation.

[107]  H. Wellens,et al.  Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardia. , 1977, British heart journal.

[108]  M. Castellano,et al.  Antihypertensive and humoral effects of verapamil and nifedipine in essential hypertension. , 1982, Journal of cardiovascular pharmacology.

[109]  E. Frohlich,et al.  Reference sample microsphere method: cardiac output and blood flows in conscious rat. , 1980, The American journal of physiology.

[110]  J. Corbett,et al.  Double-blind, randomized, placebo-controlled comparison of propranolol and verapamil in the treatment of patients with stable angina pectoris. , 1981, The American journal of medicine.

[111]  F. Ed.  Essential hypertension: hemodynamics, pressor mechanisms, and mechanisms of drug action. , 1978 .

[112]  Michael V. Green,et al.  Effects of Verapamil on Left Ventricular Systolic Function and Diastolic Filling in Patients with Hypertrophic Cardiomyopathy , 1981, Circulation.

[113]  F. Dunn,et al.  Immediate hemodynamic effects of a new calcium-channel blocking agent (nitrendipine) in essential hypertension. , 1983, The American journal of cardiology.

[114]  C. van Breemen,et al.  The mechanism of alpha-adrenergic activation of the dog coronary artery. , 1980, Circulation research.

[115]  R. O'rourke,et al.  Long-term efficacy of high-dose diltiazem for chronic stable angina pectoris: 16-month serial studies with placebo controls. , 1985, American heart journal.

[116]  J. Schroeder,et al.  Editorial: Calcium‐entry Blockade, Beta‐adrenergic Blockade and the Reflex Control of Circulation , 1982, Circulation.

[117]  D. Warltier,et al.  Reduction of myocardial infarct size by the calcium antagonist fr 7534. , 1981, Cardiology.

[118]  S. Ogawa,et al.  Protection of hypoxic myocardium by intracoronary administration of verapamil in open-chest dogs. , 1984, Circulation.

[119]  D. Krikler,et al.  Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study. , 1979, British heart journal.

[120]  D. Triggle.  Calcium, the Control of Smooth Muscle Function and Bronchial Hyperreactivity , 1983, Allergy.

[121]  F. Dunn,et al.  Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension. , 1984, The American journal of cardiology.

[122]  R. Bonow,et al.  Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy: III. Effects of long-term administration. , 1981, The American journal of cardiology.

[123]  J. Staffurth,et al.  Adverse interaction between nifedipine and beta-blockade. , 1981, British medical journal.

[124]  B. Sobel,et al.  Improved performance of ischemic canine myocardium in response to nifedipine and diltiazem. , 1980, The American journal of physiology.

[125]  P. Khairallah,et al.  Effects of Angiotensin II on DNA, RNA and Protein Synthesis , 1972 .

[126]  J. Griffith,et al.  Regional Contractility: Selective Depression of Ischemic Myocardium by Verapamil , 1976, Circulation.

[127]  T. Sugimoto,et al.  Electrophysiologic Effects of Diltiazem, a Calcium Antagonist, in Patients With Impaired Sinus or Atrioventricular Node Function , 1980, Angiology.

[128]  R. Tarazi,et al.  Reversal of cardiac hypertrophy in renal hypertensive rats: medical vs. surgical therapy. , 1981, The American journal of physiology.

[129]  C. Conti,et al.  Short-term efficacy of oral verapamil in rest angina. A double-blind placebo controlled trial in CCU patients. , 1981, The American journal of medicine.

[130]  R. Tarazi,et al.  Reversal of left ventricular hypertrophy with captopril: Heterogeneity of response among hypertensive patients , 1983, Clinical cardiology.

[131]  R. Sung,et al.  Verapamil for Control of Ventricular Rate in Paroxysmal Supraventricular Tachycardia and Atrial Fibrillation or Flutter: A Double-Blind Randomized Cross-Over Study , 2020 .

[132]  S. Vatner,et al.  α‐Adrenoceptor Attenuation of the Coronary Vascular Response to Severe Exercise in the Conscious Dog , 1979, Circulation research.

[133]  Zion Mm.  Haemodynamics of hypertension. , 1978 .

[134]  P. D. Henry.  Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. , 1980, The American journal of cardiology.

[135]  W. Frishman,et al.  β-Adrenoceptor Antagonists: New Drugs and New Indications , 1981 .

[136]  G. Droogmans,et al.  Membrane potential and excitation-contraction coupling in smooth muscle. , 1982, Federation proceedings.

[137]  C. Kelsey,et al.  Effects of nifedipine on resistance vessels, arteries and veins in man. , 1980, British journal of clinical pharmacology.

[138]  J. Federman,et al.  Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. , 1982, Australian and New Zealand journal of medicine.

[139]  G. Simonneau,et al.  Inhibition of hypoxic pulmonary vasoconstriction by nifedipine. , 1981, The New England journal of medicine.

[140]  P. Ludbrook,et al.  Acute Hemodynamic Responses to Sublingual Nifedipine: Dependence on Left Ventricular Function , 1982, Circulation.

[141]  B. Lorell,et al.  Effects of verapamil on contraction and relaxation of cultured chick embryo ventricular cells during calcium overload. , 1984, Journal of the American College of Cardiology.

[142]  C. Conti,et al.  Short- and long-term responses to diltiazem in patients with variant angina. , 1982, The American journal of cardiology.

[143]  C. Antzelevitch,et al.  Pathophysiology : altered regulatory mechanisms in disease , 1971 .

[144]  G. Klein,et al.  Acceleration of the Ventricular Response During Atrial Fibrillation in the Wolff‐Parkinson‐White Syndrome After Verapamil , 1982, Circulation.

[145]  F. Messerli,et al.  Systemic and Regional Hemodynamics in Low, Normal and High Cardiac Output Borderline Hypertension , 1978, Circulation.

[146]  J. Rouleau,et al.  Mechanism of Relief of Pacing-induced Angina with Oral Verapamil: Reduced Oxygen Demand , 1983, Circulation.

[147]  C. Conti,et al.  Effect of diltiazem in patients with variant angina: a randomized double-blind trial. , 1981, American heart journal.

[148]  L. Rydén,et al.  Comparison of metoprolol and verapamil in the treatment of angina pectoris. , 1982, The American journal of cardiology.

[149]  E. Frohlich,et al.  Regression of Left Ventricular Hypertrophy in Two‐Kidney, One Clip Goldblatt Hypertension , 1982, Hypertension.

[150]  J. Mason,et al.  Intracardiac electrophysiologic study of intravenous diltiazem and combined diltiazem-digoxin in patients. , 1982, American heart journal.

[151]  R. E. Clark,et al.  Nifedipine: a myocardial protective agent. , 1979, The American journal of cardiology.

[152]  B. G. Brown,et al.  Diltiazem-induced blockade of sympathetically mediated constriction of normal and diseased coronary arteries: lack of epicardial coronary dilatory effect in humans. , 1984, Circulation.

[153]  R. Bache,et al.  Effect of Nitroglycerin and Nifedipine on Subendocardial Perfusion in the Presence of a Flow‐Limiting Coronary Stenosis in the Awake Dog , 1982, Circulation research.

[154]  C. Kawai,et al.  Comparative Effects of Three Calcium Antagonists, Diltiazem, Verapamil and Nifedipine, on the Sinoatrial and Atrioventricular Nodes: Experimental and Clinical Studies , 1981, Circulation.

[155]  J. Weiss,et al.  Nifedipine in unstable angina: a double-blind, randomized trial. , 1982, The New England journal of medicine.

[156]  A. Fleckenstein.  History of Calcium Antagonists , 1983, Circulation research.

[157]  S. Butman,et al.  Verapamil Versus Placebo in Relieving Stable Angina Pectoris , 1982, Circulation.

[158]  K. Kohno,et al.  Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog. , 1977, Arzneimittel-Forschung.

[159]  R. E. Clark,et al.  Effect of nifedipine on myocardial ischemia: analysis of collateral flow, pulsatile heat and regional muscle shortening. , 1979, The American journal of cardiology.

[160]  A. Tonkin,et al.  Verapamil in Prophylaxis of Paroxysmal Atrioventricular Nodal Reentrant Tachycardia , 1980, Journal of cardiovascular pharmacology.

[161]  R. O'rourke,et al.  Nifedipine-induced alterations in serum quinidine concentrations. , 1984, American heart journal.

[162]  M. Bassan,et al.  Comparison of the antianginal effectiveness of nifedipine, verapamil, and isosorbide dinitrate in patients receiving propranolol: a double-blind study. , 1983, Circulation.

[163]  A. Katz,et al.  Effects of Ca Channel Blockers on Ca Transport and Ca ATPase in Skeletal and Cardiac Sarcoplasmic Reticulum Vesicles , 1982, Journal of cardiovascular pharmacology.

[164]  T. Thien,et al.  Acute treatment of hypertensive crisis with nifedipine. , 1983, British journal of clinical pharmacology.

[165]  M. Emanuel.  Specific Calcium Antagonists in the Treatment of Peripheral Vascular Disease , 1979, Angiology.

[166]  P. Christian,et al.  Comparative effects of diltiazem, propranolol, and placebo on exercise performance using radionuclide ventriculography in patients with symptomatic coronary artery disease: results of a double-blind, randomized, crossover study. , 1984, American heart journal.

[167]  N. Dhalla,et al.  Involvement of calcium in coronary vasoconstriction due to prolonged hypoxia. , 1984, American heart journal.

[168]  R. Sung,et al.  Intravenous verapamil for termination of re-entrant supraventricular tachycardias: intracardiac studies correlated with plasma verapamil concentrations. , 1980, Annals of internal medicine.

[169]  R. Myerburg,et al.  The Effects of Intravenous Verapamil on Hemodynamic Status of Patients with Coronary Artery Disease Receiving Propranolol , 1982, Circulation.

[170]  H. Emanuelsson,et al.  CORONARY ARTERY DISEASE Mechanisms of angina relief after nifedipine : a hemodynamic and myocardial metabolic study , 2005 .

[171]  E. Bolson,et al.  The Mechanisms of Nitroglycerin Action: Stenosis Vasodilatation as a Major Component of the Drug Response , 1981, Circulation.

[172]  M. Inchiosa,et al.  Isoproterenol-induced cardiomegaly: assessment of myocardial protein content, actomyosin ATPase and heart rate. , 1972, Journal of molecular and cellular cardiology.

[173]  D. Berman,et al.  Acute hemodynamic effect of oral nifedipine in severe chronic congestive heart failure. , 1983, The American journal of cardiology.

[174]  T. Yoshida,et al.  Hypotensive action and increased plasma renin activity by Ca2+ antagonist (Nifedipine) in hypertensive patients. , 1976, Japanese heart journal.

[175]  R. Helfant,et al.  Variable Effect of Nifedipine on Myocardial Blood Flow at Three Grades of Coronary Occlusion in the Dog , 1981, Circulation research.

[176]  T. Konishi,et al.  Effects of verapamil on SA and AV nodal action potentials in the isolated rabbit heart. , 1975, Japanese circulation journal.

[177]  K. Ikezawa,et al.  Studies on a new 1,5-benzothiazepine derivative (CRD-401) VI. Effects on renal blood flow and renal function. , 1974, Japanese journal of pharmacology.

[178]  T. Ryan,et al.  Efficacy and safety of verapamil in patients with angina pectoris after 1 year of continuous, high-dose therapy. , 1983, The American journal of cardiology.

[179]  R. O'rourke,et al.  Short- and long-term efficacy of high-dose oral diltiazem for angina due to coronary artery disease: a placebo-controlled, randomized, double-blind crossover study. , 1983, Circulation.

[180]  L. Opie,et al.  Adverse interaction between nifedipine and beta-blockade. , 1980, British medical journal.

[181]  L. Horwitz,et al.  Effect of verapamil on left ventricular performance in conscious dogs. , 1977, The Journal of pharmacology and experimental therapeutics.

[182]  W. Klein,et al.  Role of Calcium Antagonists in the Treatment of Essential Hypertension , 1983, Circulation research.

[183]  R. Zelis,et al.  Nifedipine therapy for stable angina pectoris: preliminary results of effects on angina frequency and treadmill exercise response. , 1979, The American journal of cardiology.

[184]  N. Trippodo,et al.  Similarities of Genetic (Spontaneous) Hypertension: Man and Rat , 1981, Circulation research.

[185]  A. Michelucci,et al.  The cardiac electrophysiological effects of nifedipine. , 1979, International journal of clinical pharmacology and biopharmacy.

[186]  E. Braunwald,et al.  Preservation of high-energy phosphates by verapamil in reperfused myocardium. , 1984, Circulation.

[187]  R. Gorlin,et al.  Propranolol and angina pectoris. , 1966, The American journal of cardiology.

[188]  M. Vassalle.  The Role of the Slow Inward Current in Impulse Formation , 1980 .

[189]  R. Millard,et al.  Reflex Chronotropic and Inotropic Effects of Calcium Channel‐Blocking Agents in Conscious Dogs: Diltiazem, Verapamil, and Nifedipine Compared , 1983, Circulation research.

[190]  D. Mathey,et al.  Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophic cardiomyopathy. , 1980, The American journal of cardiology.

[191]  M. Endo,et al.  Calcium release from the sarcoplasmic reticulum. , 1977, Physiological reviews.

[192]  H. Klein,et al.  The effect of two different diltiazem treatments on infarct size in ischemic, reperfused porcine hearts. , 1984, Circulation.

[193]  W. Bussmann,et al.  Treatment of hypertrophic obstructive cardiomyopathy with verapamil , 1980, British heart journal.

[194]  A. Fleckenstein.  Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. , 1977, Annual review of pharmacology and toxicology.

[195]  M. Olivari,et al.  Treatment of Hypertension with Nifedipine, A Calcium Antagonistic Agent , 1979, Circulation.

[196]  D. Kelly,et al.  Verapamil in stable effort angina: effects on left ventricular function evaluated with exercise radionuclide ventriculography. , 1982, The American journal of cardiology.

[197]  E. Feigl,et al.  Competition between Sympathetic Vasoconstriction and Metabolic Vasodilation in the Canine Coronary Circulation , 1978, Circulation research.

[198]  R. O'rourke,et al.  Direct and indirect effects of calcium entry blocking agents on isovolumic left ventricular relaxation in conscious dogs. , 1985, The Journal of clinical investigation.

[199]  E. Feigl,et al.  Adrenergic Coronary Vasoconstriction in the Presence of Coronary Stenosis in the Dog , 1981, Circulation research.

[200]  Bramahn . Singh,et al.  Effects of intravenous verapamil on hemodynamics in patients with heart disease. , 1977, American heart journal.

[201]  E. Frohlich,et al.  Clinical‐Physiological Correlations in the Development of Hypertensive Heart Disease , 1971, Circulation.

[202]  R. Gorlin,et al.  Hemodynamic Consequences of Combined Beta‐adrenergic and Slow Calcium Channel Blockade in Man , 1982, Circulation.

[203]  B. Chaitman,et al.  Improved exercise tolerance after propranolol, diltiazem or nifedipine in angina pectoris: comparison at 1, 3 and 8 hours and correlation with plasma drug concentration. , 1984, The American journal of cardiology.

[204]  S. Connolly,et al.  The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study. , 1983, Circulation.

[205]  R. Rodeheffer,et al.  Controlled double-blind trial of nifedipine in the treatment of Raynaud's phenomenon. , 1983, The New England journal of medicine.

[206]  W. Aronow,et al.  Effects of verapamil on myocardial performance in coronary disease. , 1979, Circulation.

[207]  A. DeMaria,et al.  Efficacy of diltiazem in angina on effort: a multicenter trial. , 1982, The American journal of cardiology.

[208]  B. Gould,et al.  Nifedipine tablets for systemic hypertension: a study using continuous ambulatory intraarterial recording. , 1983, The American journal of cardiology.

[209]  F. Ed.  Hemodynamic factors in the pathogenesis and maintenance of hypertension. , 1982 .

[210]  C. McKay,et al.  Comparison of hemodynamic responses to nifedipine and nitroprusside in severe chronic congestive heart failure. , 1984, The American journal of cardiology.