Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.

Multifunctional nanoparticles have the potential to integrate therapeutic and diagnostic functions into a single nanodevice.[1–9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multi-modal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI).[10–15] While these nanocomposites have been used for in vitro magnetic cell separation and in vitro cell targeting, there are limited in vivo studies, particularly for cancer imaging and therapy, due to poor stability or short systemic circulation times generally observed for these more complicated nanostructures.[16, 17] Herein, we introduce long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG)-phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR-fluorescent and MR imaging of diseased tissue in vitro and in vivo.

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