Use of a novel beta-tricalcium phosphate-based bone void filler as a graft extender in spinal fusion surgeries.

Synthetic bone void fillers are gaining acceptance as graft extenders in spinal surgery. One such product is an ultraporous formulation of nanometer-sized particles of beta-tricalcium phosphate (beta-TCP). An ongoing prospective open-label, randomized, observer-blinded, comparative study evaluated the efficacy and safety of a novel beta-TCP bone void filler as an additive to autogenous bone graft material in patients undergoing spinal fusion. Posterolateral instrumented or noninstrumented spinal fusion was performed at a single level or multiple levels with or without additional interbody fusion. Patients received autogenous bone on 1 side and autogenous bone augmented with extender (in a 1:1 ratio based on the weight of the materials) on the opposite side, each patient serving as his or her own control. The graft material was placed at the level of the facet joints and the intertransverse processes. Patients were randomized to receive the extender on either the right or the left side. This article is a preliminary report on patients who have undergone this procedure.

[1]  T. L. Fernando,et al.  Complete pelvic ring failure after posterior iliac bone graft harvesting. , 1999, Spine.

[2]  J. Bouler,et al.  Macroporous calcium phosphate ceramic: a prospective study of 106 cases in lumbar spinal fusion. , 1999, Journal of long-term effects of medical implants.

[3]  Cameron Hu.  Tricalcium phosphate as a bone graft substitute. , 1992 .

[4]  V. Goldberg,et al.  The Effect of Implants Loaded with Autologous Mesenchymal Stem Cells on the Healing of Canine Segmental Bone Defects* , 1998, The Journal of bone and joint surgery. American volume.

[5]  H N Herkowitz,et al.  Pseudarthrosis of the spine. , 1992, Clinical orthopaedics and related research.

[6]  C. Cornell,et al.  Osteoconductive materials and their role as substitutes for autogenous bone grafts. , 1999, The Orthopedic clinics of North America.

[7]  H. Chambers,et al.  Complications of iliac crest bone graft harvesting. , 1996, Clinical orthopaedics and related research.

[8]  T. Clineff,et al.  Potential of an ultraporous β-tricalcium phosphate synthetic cancellous bone void filler and bone marrow aspirate composite graft , 2001, European Spine Journal.

[9]  J F Connolly,et al.  Autologous marrow injection as a substitute for operative grafting of tibial nonunions. , 1991, Clinical orthopaedics and related research.

[10]  D. Wise,et al.  Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats. , 2000, Biomaterials.

[11]  N. Scarborough,et al.  Allograft bone. The influence of processing on safety and performance. , 1999, The Orthopedic clinics of North America.

[12]  G. Muschler,et al.  Bone cells and matrices in orthopedic tissue engineering. , 2000, The Orthopedic clinics of North America.

[13]  A. Levine,et al.  Chronic Donor Site Pain Complicating Bone Graft Harvesting From the Posterior Iliac Crest for Spinal Fusion , 1992, Spine.

[14]  G. Lowery,et al.  Use of autologous growth factors in lumbar spinal fusion. , 1999, Bone.

[15]  J. Haselkorn,et al.  Patient outcomes after lumbar spinal fusions. , 1992, JAMA.

[16]  A. Vaccaro,et al.  The Use of Allograft Bone in Lumbar Spine Surgery , 2000, Clinical orthopaedics and related research.

[17]  B. Summers,et al.  Donor site pain from the ilium. A complication of lumbar spine fusion. , 1989, The Journal of bone and joint surgery. British volume.

[18]  M. McAndrew,et al.  Tricalcium phosphate as a bone graft substitute in trauma: preliminary report. , 1988 .

[19]  R Z LeGeros,et al.  Calcium phosphates in oral biology and medicine. , 1991, Monographs in oral science.

[20]  Hurley Rw,et al.  Fracture at the iliac bone graft harvest site after fusion of the spine. , 1994 .

[21]  G. Carter.  Harvesting and implanting allograft bone. , 1999, AORN journal.

[22]  Pelker Rr,et al.  Biomechanical aspects of bone autografts and allografts. , 1987 .

[23]  H. Parvataneni,et al.  Bone grafting for spinal fusion. , 1999, The Orthopedic clinics of North America.

[24]  G. Muschler,et al.  Bone graft materials. An overview of the basic science. , 2000, Clinical orthopaedics and related research.

[25]  M. Dösogˇlu,et al.  Enterocutaneous Fistula: A Complication of Posterior Iliac Bone Graft Harvesting not Previously Described , 1998, Acta Neurochirurgica.

[26]  M. Lotem,et al.  Lumbar hernia at an iliac bone graft donor site. A case report. , 1971, Clinical orthopaedics and related research.

[27]  A Boyde,et al.  Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. , 2000, Journal of biomedical materials research.